ID   GARR_ECOL6              Reviewed;         294 AA.
AC   P0ABQ3; P23523;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=2-hydroxy-3-oxopropionate reductase;
DE            EC=1.1.1.60;
DE   AltName: Full=Tartronate semialdehyde reductase;
DE            Short=TSAR;
GN   Name=garR; OrderedLocusNames=c3880;
OS   Escherichia coli O6.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=217992;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O6:H1 / CFT073 / ATCC 700928 / UPEC;
RX   MEDLINE=22388234; PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P.,
RA   Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D.,
RA   Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T.,
RA   Mobley H.L.T., Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence
RT   of uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- CATALYTIC ACTIVITY: (R)-glycerate + NAD(P)(+) = 2-hydroxy-3-
CC       oxopropanoate + NAD(P)H.
CC   -!- PATHWAY: Carbohydrate acid metabolism; D-galactaric acid
CC       degradation; D-glyceric acid from D-galactaric acid: step 3/3.
CC   -!- SIMILARITY: Belongs to the 3-hydroxyisobutyrate dehydrogenase
CC       family.
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DR   EMBL; AE014075; AAN82321.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_755747.2; -.
DR   SMR; P0ABQ3; 1-294.
DR   GeneID; 1040122; -.
DR   GenomeReviews; AE014075_GR; c3880.
DR   KEGG; ecc:c3880; -.
DR   HOGENOM; P0ABQ3; -.
DR   OMA; P0ABQ3; HTGAIGA.
DR   BRENDA; 1.1.1.60; 292881.
DR   GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:EC.
DR   GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxyla...; IEA:InterPro.
DR   GO; GO:0046487; P:glyoxylate metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:InterPro.
DR   GO; GO:0006573; P:valine metabolic process; IEA:InterPro.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR015815; 3hydroxyacid_DH/Rdtase.
DR   InterPro; IPR006183; 6-phosphogluconate_DH.
DR   InterPro; IPR006115; 6PGDH_NAD-bd.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR006398; Tartro_sem_red.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   PANTHER; PTHR22981; 3hydroxy_acid_DH; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PRINTS; PR00076; 6PGDHDRGNASE.
DR   TIGRFAMs; TIGR01505; tartro_sem_red; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    294       2-hydroxy-3-oxopropionate reductase.
FT                                /FTId=PRO_0000173060.
FT   ACT_SITE    170    170       By similarity.
SQ   SEQUENCE   294 AA;  30427 MW;  17DA392C2253278C CRC64;
     MKVGFIGLGI MGKPMSKNLL KAGYSLVVAD RNPEAIADVI AAGAETASTA KAIAEQCDVI
     ITMLPNSPHV KEVALGENGI IEGAKPGTVL IDMSSIAPLA SREISEALKA KGIDMLDAPV
     SGGEPKAIDG TLSVMVGGDK AIFDKYYDLM KAMAGSVVHT GEIGAGNVTK LANQVIVALN
     IAAMSEALTL ATKAGVNPDL VYQAIRGGLA GSTVLDAKAP MVMDRNFKPG FRIDLHIKDL
     ANALDTSHGV GAQLPLTAAV MEMMQALRAD GLGTADHSAL ACYYEKLAKV EVTR
//