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Protein

Purine nucleoside phosphorylase DeoD-type

Gene

deoD

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules.By similarity

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation
Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei5Purine nucleoside; shared with dimeric partner1 Publication1
Binding sitei21Phosphate; via amide nitrogen1 Publication1
Binding sitei25Phosphate1 Publication1
Binding sitei44Phosphate; shared with dimeric partner1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylase DeoD-typeUniRule annotation (EC:2.4.2.1UniRule annotation)
Short name:
PNPUniRule annotation
Gene namesi
Name:deoDUniRule annotation
Ordered Locus Names:Z5986, ECs5343
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000631312 – 239Purine nucleoside phosphorylase DeoD-typeAdd BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27N6-acetyllysineUniRule annotation1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP0ABP9

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z5986

Structurei

Secondary structure

1239
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi15 – 19Combined sources5
Helixi24 – 33Combined sources10
Beta strandi35 – 41Combined sources7
Helixi43 – 45Combined sources3
Beta strandi48 – 53Combined sources6
Beta strandi56 – 61Combined sources6
Helixi67 – 80Combined sources14
Beta strandi85 – 93Combined sources9
Beta strandi104 – 113Combined sources10
Helixi116 – 120Combined sources5
Turni121 – 123Combined sources3
Helixi132 – 144Combined sources13
Beta strandi149 – 156Combined sources8
Helixi166 – 173Combined sources8
Beta strandi178 – 182Combined sources5
Helixi183 – 192Combined sources10
Beta strandi196 – 205Combined sources10
Helixi215 – 237Combined sources23

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PK7X-ray2.50A/B/C2-238[»]
1PK9X-ray1.90A/B/C2-238[»]
1PKEX-ray2.30A/B/C2-238[»]
1PR0X-ray2.20A/B/C1-239[»]
1PR1X-ray2.30A/B/C1-239[»]
1PR2X-ray2.30A/B/C1-239[»]
1PR4X-ray2.40A/B/C1-239[»]
1PR5X-ray2.50A/B/C1-239[»]
1PR6X-ray2.10A/B/C1-239[»]
1PW7X-ray2.00A/B/C1-239[»]
ProteinModelPortaliP0ABP9
SMRiP0ABP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 91Phosphate binding1 Publication4
Regioni180 – 182Purine nucleoside binding1 Publication3
Regioni204 – 205Purine nucleoside binding1 Publication2

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D3A Bacteria
COG0813 LUCA
HOGENOMiHOG000274896
KOiK03784
OMAiPQCLLCG

Family and domain databases

HAMAPiMF_01627 Pur_nucleosid_phosp, 1 hit
InterProiView protein in InterPro
IPR004402 DeoD-type
IPR018016 Nucleoside_phosphorylase_CS
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
PANTHERiPTHR43691:SF2 PTHR43691:SF2, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR00107 deoD, 1 hit
PROSITEiView protein in PROSITE
PS01232 PNP_UDP_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ABP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPHINAEM GDFADVVLMP GDPLRAKYIA ETFLEDAREV NNVRGMLGFT
60 70 80 90 100
GTYKGRKISV MGHGMGIPSC SIYTKELITD FGVKKIIRVG SCGAVLPHVK
110 120 130 140 150
LRDVVIGMGA CTDSKVNRIR FKDHDFAAIA DFDMVRNAVD AAKALGIDAR
160 170 180 190 200
VGNLFSADLF YSPDGEMFDV MEKYGILGVE MEAAGIYGVA AEFGAKALTI
210 220 230
CTVSDHIRTH EQTTAAERQT TFNDMIKIAL ESVLLGDKE
Length:239
Mass (Da):25,950
Last modified:January 23, 2007 - v2
Checksum:i71D3DFAA5A176970
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG59565.1
BA000007 Genomic DNA Translation: BAB38766.1
PIRiA86138
G91296
RefSeqiNP_313370.1, NC_002695.1
WP_000224877.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG59565; AAG59565; Z5986
BAB38766; BAB38766; BAB38766
GeneIDi913500
KEGGiece:Z5986
ecs:ECs5343
PATRICifig|386585.9.peg.5590

Similar proteinsi

Entry informationi

Entry nameiDEOD_ECO57
AccessioniPrimary (citable) accession number: P0ABP9
Secondary accession number(s): P09743
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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