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Protein

Protein DedA

Gene

dedA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciEcoCyc:EG10216-MONOMER.
ECOL316407:JW2314-MONOMER.

Protein family/group databases

TCDBi9.B.27.2.3. the deda or ydjx-z (deda) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DedA
Alternative name(s):
Protein DSG-1
Gene namesi
Name:dedA
Ordered Locus Names:b2317, JW2314
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10216. dedA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424PeriplasmicSequence analysisAdd
BLAST
Transmembranei25 – 4521HelicalSequence analysisAdd
BLAST
Transmembranei46 – 6621HelicalSequence analysisAdd
BLAST
Topological domaini67 – 726PeriplasmicSequence analysis
Transmembranei73 – 9321HelicalSequence analysisAdd
BLAST
Topological domaini94 – 16067CytoplasmicSequence analysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Topological domaini182 – 1876PeriplasmicSequence analysis
Transmembranei188 – 20821HelicalSequence analysisAdd
BLAST
Topological domaini209 – 21911CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Protein DedAPRO_0000161406Add
BLAST

Proteomic databases

PaxDbiP0ABP6.

Interactioni

Protein-protein interaction databases

BioGridi4261363. 8 interactions.
DIPiDIP-48027N.
IntActiP0ABP6. 1 interaction.
STRINGi511145.b2317.

Structurei

3D structure databases

ProteinModelPortaliP0ABP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DedA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DQR. Bacteria.
COG0586. LUCA.
HOGENOMiHOG000105368.
InParanoidiP0ABP6.
KOiK03975.
OMAiYLDKTHE.
OrthoDBiEOG6D2KZK.
PhylomeDBiP0ABP6.

Family and domain databases

InterProiIPR032818. DedA.
IPR032816. SNARE_assoc.
[Graphical view]
PANTHERiPTHR30353. PTHR30353. 1 hit.
PfamiPF09335. SNARE_assoc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ABP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLIYFLIDF ILHIDVHLAE LVAEYGVWVY AILFLILFCE TGLVVTPFLP
60 70 80 90 100
GDSLLFVAGA LASLETNDLN VHMMVVLMLI AAIVGDAVNY TIGRLFGEKL
110 120 130 140 150
FSNPNSKIFR RSYLDKTHQF YEKHGGKTII LARFVPIVRT FAPFVAGMGH
160 170 180 190 200
MSYRHFAAYN VIGALLWVLL FTYAGYFFGT IPMVQDNLKL LIVGIIVVSI
210
LPGVIEIIRH KRAAARAAK
Length:219
Mass (Da):24,510
Last modified:November 8, 2005 - v1
Checksum:i37F38ABAB8678C20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68934 Genomic DNA. Translation: AAA23964.1.
U00096 Genomic DNA. Translation: AAC75377.1.
AP009048 Genomic DNA. Translation: BAA16174.1.
M15543 Genomic DNA. Translation: AAA24314.1.
X02743 Genomic DNA. Translation: CAA26523.1.
S53037 mRNA. Translation: AAB24893.1.
PIRiB29803. XMECAD.
RefSeqiNP_416820.1. NC_000913.3.
WP_000364335.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75377; AAC75377; b2317.
BAA16174; BAA16174; BAA16174.
GeneIDi946798.
KEGGiecj:JW2314.
eco:b2317.
PATRICi32120005. VBIEscCol129921_2412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68934 Genomic DNA. Translation: AAA23964.1.
U00096 Genomic DNA. Translation: AAC75377.1.
AP009048 Genomic DNA. Translation: BAA16174.1.
M15543 Genomic DNA. Translation: AAA24314.1.
X02743 Genomic DNA. Translation: CAA26523.1.
S53037 mRNA. Translation: AAB24893.1.
PIRiB29803. XMECAD.
RefSeqiNP_416820.1. NC_000913.3.
WP_000364335.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ABP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261363. 8 interactions.
DIPiDIP-48027N.
IntActiP0ABP6. 1 interaction.
STRINGi511145.b2317.

Protein family/group databases

TCDBi9.B.27.2.3. the deda or ydjx-z (deda) family.

Proteomic databases

PaxDbiP0ABP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75377; AAC75377; b2317.
BAA16174; BAA16174; BAA16174.
GeneIDi946798.
KEGGiecj:JW2314.
eco:b2317.
PATRICi32120005. VBIEscCol129921_2412.

Organism-specific databases

EchoBASEiEB0212.
EcoGeneiEG10216. dedA.

Phylogenomic databases

eggNOGiENOG4105DQR. Bacteria.
COG0586. LUCA.
HOGENOMiHOG000105368.
InParanoidiP0ABP6.
KOiK03975.
OMAiYLDKTHE.
OrthoDBiEOG6D2KZK.
PhylomeDBiP0ABP6.

Enzyme and pathway databases

BioCyciEcoCyc:EG10216-MONOMER.
ECOL316407:JW2314-MONOMER.

Miscellaneous databases

PROiP0ABP6.

Family and domain databases

InterProiIPR032818. DedA.
IPR032816. SNARE_assoc.
[Graphical view]
PANTHERiPTHR30353. PTHR30353. 1 hit.
PfamiPF09335. SNARE_assoc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The hisT-purF region of the Escherichia coli K-12 chromosome. Identification of additional genes of the hisT and purF operons."
    Nonet M.L., Marvel C.C., Tolan D.R.
    J. Biol. Chem. 262:12209-12217(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Structural analysis of the Escherichia coli K-12 hisT operon by using a kanamycin resistance cassette."
    Arps P.J., Winkler M.E.
    J. Bacteriol. 169:1061-1070(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
    Strain: K12.
  6. "Growth rate regulation of Escherichia coli acetyl coenzyme A carboxylase, which catalyzes the first committed step of lipid biosynthesis."
    Li S.-J., Cronan J.E. Jr.
    J. Bacteriol. 175:332-340(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-219.
  7. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiDEDA_ECOLI
AccessioniPrimary (citable) accession number: P0ABP6
Secondary accession number(s): P09548
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: January 20, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.