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Protein

Anaerobic C4-dicarboxylate transporter DcuC

Gene

dcuC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Responsible for the transport of C4-dicarboxylates during anaerobic growth.1 Publication

GO - Molecular functioni

GO - Biological processi

  • C4-dicarboxylate transport Source: EcoliWiki
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:DCUC-MONOMER.
ECOL316407:JW0613-MONOMER.
ECOL316407:JW0616-MONOMER.
MetaCyc:DCUC-MONOMER.

Protein family/group databases

TCDBi2.A.61.1.1. the c4-dicarboxylate uptake c (dcuc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic C4-dicarboxylate transporter DcuC
Gene namesi
Name:dcuC
Ordered Locus Names:b0621, JW0613/JW0616
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13545. dcuC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Transmembranei436 – 456HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002016271 – 461Anaerobic C4-dicarboxylate transporter DcuCAdd BLAST461

Proteomic databases

PaxDbiP0ABP3.
PRIDEiP0ABP3.

Interactioni

Protein-protein interaction databases

STRINGi511145.b0621.

Structurei

3D structure databases

ProteinModelPortaliP0ABP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CEE. Bacteria.
COG3069. LUCA.
HOGENOMiHOG000274996.
KOiK03326.
OMAiDVAYRGM.

Family and domain databases

InterProiIPR004669. C4_dicarb_anaerob_car.
IPR018385. C4_dicarb_anaerob_car-like.
[Graphical view]
PfamiPF03606. DcuC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00771. DcuC. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTFIELLIG VVVIVGVARY IIKGYSATGV LFVGGLLLLI ISAIMGHKVL
60 70 80 90 100
PSSQASTGYS ATDIVEYVKI LLMSRGGDLG MMIMMLCGFA AYMTHIGAND
110 120 130 140 150
MVVKLASKPL QYINSPYLLM IAAYFVACLM SLAVSSATGL GVLLMATLFP
160 170 180 190 200
VMVNVGISRG AAAAICASPA AIILAPTSGD VVLAAQASEM SLIDFAFKTT
210 220 230 240 250
LPISIAAIIG MAIAHFFWQR YLDKKEHISH EMLDVSEITT TAPAFYAILP
260 270 280 290 300
FTPIIGVLIF DGKWGPQLHI ITILVICMLI ASILEFLRSF NTQKVFSGLE
310 320 330 340 350
VAYRGMADAF ANVVMLLVAA GVFAQGLSTI GFIQSLISIA TSFGSASIIL
360 370 380 390 400
MLVLVILTML AAVTTGSGNA PFYAFVEMIP KLAHSSGINP AYLTIPMLQA
410 420 430 440 450
SNLGRTLSPV SGVVVAVAGM AKISPFEVVK RTSVPVLVGL VIVIVATELM
460
VPGTAAAVTG K
Length:461
Mass (Da):48,412
Last modified:November 8, 2005 - v1
Checksum:iD4042FBFE9F562ED
GO

Sequence cautioni

The sequence BAA35263 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99112 Genomic DNA. Translation: CAA67561.1.
U82598 Genomic DNA. Translation: AAB40821.1.
U00096 Genomic DNA. Translation: AAC73722.1.
AP009048 Genomic DNA. Translation: BAA35264.1. Different termination.
AP009048 Genomic DNA. Translation: BAA35263.1. Different initiation.
PIRiC64796.
RefSeqiNP_415154.1. NC_000913.3.
WP_000955063.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73722; AAC73722; b0621.
BAA35263; BAA35263; BAA35263.
BAA35264; BAA35264; BAA35264.
GeneIDi945000.
KEGGiecj:JW0613.
ecj:JW0616.
eco:b0621.
PATRICi32116422. VBIEscCol129921_0651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99112 Genomic DNA. Translation: CAA67561.1.
U82598 Genomic DNA. Translation: AAB40821.1.
U00096 Genomic DNA. Translation: AAC73722.1.
AP009048 Genomic DNA. Translation: BAA35264.1. Different termination.
AP009048 Genomic DNA. Translation: BAA35263.1. Different initiation.
PIRiC64796.
RefSeqiNP_415154.1. NC_000913.3.
WP_000955063.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ABP3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511145.b0621.

Protein family/group databases

TCDBi2.A.61.1.1. the c4-dicarboxylate uptake c (dcuc) family.

Proteomic databases

PaxDbiP0ABP3.
PRIDEiP0ABP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73722; AAC73722; b0621.
BAA35263; BAA35263; BAA35263.
BAA35264; BAA35264; BAA35264.
GeneIDi945000.
KEGGiecj:JW0613.
ecj:JW0616.
eco:b0621.
PATRICi32116422. VBIEscCol129921_0651.

Organism-specific databases

EchoBASEiEB3315.
EcoGeneiEG13545. dcuC.

Phylogenomic databases

eggNOGiENOG4105CEE. Bacteria.
COG3069. LUCA.
HOGENOMiHOG000274996.
KOiK03326.
OMAiDVAYRGM.

Enzyme and pathway databases

BioCyciEcoCyc:DCUC-MONOMER.
ECOL316407:JW0613-MONOMER.
ECOL316407:JW0616-MONOMER.
MetaCyc:DCUC-MONOMER.

Miscellaneous databases

PROiP0ABP3.

Family and domain databases

InterProiIPR004669. C4_dicarb_anaerob_car.
IPR018385. C4_dicarb_anaerob_car-like.
[Graphical view]
PfamiPF03606. DcuC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00771. DcuC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCUC_ECOLI
AccessioniPrimary (citable) accession number: P0ABP3
Secondary accession number(s): Q47134, Q9ZBC9, Q9ZBD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

PubMed:8905232 and PubMed:16738553 sequences differ from that shown due to the presence of an IS5 insertion element between codons 327 and 328. Strain W3110A but not W3110B harbors this IS5 insertion.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.