Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anaerobic C4-dicarboxylate transporter DcuB

Gene

dcuB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane.

GO - Molecular functioni

GO - Biological processi

  • C4-dicarboxylate transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:DCUB-MONOMER.
ECOL316407:JW4084-MONOMER.
MetaCyc:DCUB-MONOMER.

Protein family/group databases

TCDBi2.A.13.1.2. the c4-dicarboxylate uptake (dcu) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic C4-dicarboxylate transporter DcuB
Gene namesi
Name:dcuB
Synonyms:genF
Ordered Locus Names:b4123, JW4084
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10006. dcuB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 19HelicalBy similarityAdd BLAST19
Topological domaini20CytoplasmicBy similarity1
Transmembranei21 – 39HelicalBy similarityAdd BLAST19
Topological domaini40 – 55PeriplasmicBy similarityAdd BLAST16
Transmembranei56 – 73HelicalBy similarityAdd BLAST18
Topological domaini74 – 87CytoplasmicBy similarityAdd BLAST14
Transmembranei88 – 105HelicalBy similarityAdd BLAST18
Topological domaini106 – 134PeriplasmicBy similarityAdd BLAST29
Transmembranei135 – 149HelicalBy similarityAdd BLAST15
Topological domaini150 – 240CytoplasmicBy similarityAdd BLAST91
Transmembranei241 – 258HelicalBy similarityAdd BLAST18
Topological domaini259 – 275PeriplasmicBy similarityAdd BLAST17
Transmembranei276 – 293HelicalBy similarityAdd BLAST18
Topological domaini294 – 303CytoplasmicBy similarity10
Transmembranei304 – 321HelicalBy similarityAdd BLAST18
Topological domaini322 – 343PeriplasmicBy similarityAdd BLAST22
Transmembranei344 – 361HelicalBy similarityAdd BLAST18
Topological domaini362 – 366CytoplasmicBy similarity5
Transmembranei367 – 384HelicalBy similarityAdd BLAST18
Topological domaini385 – 446PeriplasmicBy similarityAdd BLAST62

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001703551 – 446Anaerobic C4-dicarboxylate transporter DcuBAdd BLAST446

Proteomic databases

PaxDbiP0ABN9.
PRIDEiP0ABN9.

Interactioni

Protein-protein interaction databases

BioGridi4260911. 9 interactors.
STRINGi511145.b4123.

Structurei

3D structure databases

ProteinModelPortaliP0ABN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DS2. Bacteria.
COG2704. LUCA.
HOGENOMiHOG000272417.
InParanoidiP0ABN9.
KOiK07792.
OMAiDKDPEFQ.
PhylomeDBiP0ABN9.

Family and domain databases

InterProiIPR004668. Anaer_Dcu_memb_transpt.
[Graphical view]
PfamiPF03605. DcuA_DcuB. 1 hit.
[Graphical view]
PIRSFiPIRSF004539. C4-dicrbxl_trns. 1 hit.
TIGRFAMsiTIGR00770. Dcu. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFTIQLIII LICLFYGARK GGIALGLLGG IGLVILVFVF HLQPGKPPVD
60 70 80 90 100
VMLVIIAVVA ASATLQASGG LDVMLQIAEK LLRRNPKYVS IVAPFVTCTL
110 120 130 140 150
TILCGTGHVV YTILPIIYDV AIKNNIRPER PMAASSIGAQ MGIIASPVSV
160 170 180 190 200
AVVSLVAMLG NVTFDGRHLE FLDLLAITIP STLIGILAIG IFSWFRGKDL
210 220 230 240 250
DKDEEFQKFI SVPENREYVY GDTATLLDKK LPKSNWLAMW IFLGAIAVVA
260 270 280 290 300
LLGADSDLRP SFGGKPLSMV LVIQMFMLLT GALIIILTKT NPASISKNEV
310 320 330 340 350
FRSGMIAIVA VYGIAWMAET MFGAHMSEIQ GVLGEMVKEY PWAYAIVLLL
360 370 380 390 400
VSKFVNSQAA ALAAIVPVAL AIGVDPAYIV ASAPACYGYY ILPTYPSDLA
410 420 430 440
AIQFDRSGTT HIGRFVINHS FILPGLIGVS VSCVFGWIFA AMYGFL
Length:446
Mass (Da):47,935
Last modified:November 8, 2005 - v1
Checksum:iB4AF89BB2E0CCB3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79886 Genomic DNA. Translation: CAA56258.1.
U14003 Genomic DNA. Translation: AAA97023.1.
U00096 Genomic DNA. Translation: AAC77084.1.
AP009048 Genomic DNA. Translation: BAE78125.1.
M27058 Genomic DNA. Translation: AAA23826.1.
PIRiS56352.
RefSeqiNP_418547.1. NC_000913.3.
WP_000899522.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77084; AAC77084; b4123.
BAE78125; BAE78125; BAE78125.
GeneIDi948641.
KEGGiecj:JW4084.
eco:b4123.
PATRICi32123811. VBIEscCol129921_4254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79886 Genomic DNA. Translation: CAA56258.1.
U14003 Genomic DNA. Translation: AAA97023.1.
U00096 Genomic DNA. Translation: AAC77084.1.
AP009048 Genomic DNA. Translation: BAE78125.1.
M27058 Genomic DNA. Translation: AAA23826.1.
PIRiS56352.
RefSeqiNP_418547.1. NC_000913.3.
WP_000899522.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ABN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260911. 9 interactors.
STRINGi511145.b4123.

Protein family/group databases

TCDBi2.A.13.1.2. the c4-dicarboxylate uptake (dcu) family.

Proteomic databases

PaxDbiP0ABN9.
PRIDEiP0ABN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77084; AAC77084; b4123.
BAE78125; BAE78125; BAE78125.
GeneIDi948641.
KEGGiecj:JW4084.
eco:b4123.
PATRICi32123811. VBIEscCol129921_4254.

Organism-specific databases

EchoBASEiEB0006.
EcoGeneiEG10006. dcuB.

Phylogenomic databases

eggNOGiENOG4105DS2. Bacteria.
COG2704. LUCA.
HOGENOMiHOG000272417.
InParanoidiP0ABN9.
KOiK07792.
OMAiDKDPEFQ.
PhylomeDBiP0ABN9.

Enzyme and pathway databases

BioCyciEcoCyc:DCUB-MONOMER.
ECOL316407:JW4084-MONOMER.
MetaCyc:DCUB-MONOMER.

Miscellaneous databases

PROiP0ABN9.

Family and domain databases

InterProiIPR004668. Anaer_Dcu_memb_transpt.
[Graphical view]
PfamiPF03605. DcuA_DcuB. 1 hit.
[Graphical view]
PIRSFiPIRSF004539. C4-dicrbxl_trns. 1 hit.
TIGRFAMsiTIGR00770. Dcu. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCUB_ECOLI
AccessioniPrimary (citable) accession number: P0ABN9
Secondary accession number(s): P14409, Q2M6I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.