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Protein

Anaerobic C4-dicarboxylate transporter DcuB

Gene

dcuB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane.

GO - Molecular functioni

GO - Biological processi

  • C4-dicarboxylate transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:DCUB-MONOMER.
ECOL316407:JW4084-MONOMER.
MetaCyc:DCUB-MONOMER.

Protein family/group databases

TCDBi2.A.13.1.2. the c4-dicarboxylate uptake (dcu) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic C4-dicarboxylate transporter DcuB
Gene namesi
Name:dcuB
Synonyms:genF
Ordered Locus Names:b4123, JW4084
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10006. dcuB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 1919HelicalBy similarityAdd
BLAST
Topological domaini20 – 201CytoplasmicBy similarity
Transmembranei21 – 3919HelicalBy similarityAdd
BLAST
Topological domaini40 – 5516PeriplasmicBy similarityAdd
BLAST
Transmembranei56 – 7318HelicalBy similarityAdd
BLAST
Topological domaini74 – 8714CytoplasmicBy similarityAdd
BLAST
Transmembranei88 – 10518HelicalBy similarityAdd
BLAST
Topological domaini106 – 13429PeriplasmicBy similarityAdd
BLAST
Transmembranei135 – 14915HelicalBy similarityAdd
BLAST
Topological domaini150 – 24091CytoplasmicBy similarityAdd
BLAST
Transmembranei241 – 25818HelicalBy similarityAdd
BLAST
Topological domaini259 – 27517PeriplasmicBy similarityAdd
BLAST
Transmembranei276 – 29318HelicalBy similarityAdd
BLAST
Topological domaini294 – 30310CytoplasmicBy similarity
Transmembranei304 – 32118HelicalBy similarityAdd
BLAST
Topological domaini322 – 34322PeriplasmicBy similarityAdd
BLAST
Transmembranei344 – 36118HelicalBy similarityAdd
BLAST
Topological domaini362 – 3665CytoplasmicBy similarity
Transmembranei367 – 38418HelicalBy similarityAdd
BLAST
Topological domaini385 – 44662PeriplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Anaerobic C4-dicarboxylate transporter DcuBPRO_0000170355Add
BLAST

Proteomic databases

PaxDbiP0ABN9.
PRIDEiP0ABN9.

Interactioni

Protein-protein interaction databases

BioGridi4260911. 9 interactions.
STRINGi511145.b4123.

Structurei

3D structure databases

ProteinModelPortaliP0ABN9.
SMRiP0ABN9. Positions 335-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DS2. Bacteria.
COG2704. LUCA.
HOGENOMiHOG000272417.
InParanoidiP0ABN9.
KOiK07792.
OMAiDKDPEFQ.
PhylomeDBiP0ABN9.

Family and domain databases

InterProiIPR004668. Anaer_Dcu_memb_transpt.
[Graphical view]
PfamiPF03605. DcuA_DcuB. 1 hit.
[Graphical view]
PIRSFiPIRSF004539. C4-dicrbxl_trns. 1 hit.
TIGRFAMsiTIGR00770. Dcu. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFTIQLIII LICLFYGARK GGIALGLLGG IGLVILVFVF HLQPGKPPVD
60 70 80 90 100
VMLVIIAVVA ASATLQASGG LDVMLQIAEK LLRRNPKYVS IVAPFVTCTL
110 120 130 140 150
TILCGTGHVV YTILPIIYDV AIKNNIRPER PMAASSIGAQ MGIIASPVSV
160 170 180 190 200
AVVSLVAMLG NVTFDGRHLE FLDLLAITIP STLIGILAIG IFSWFRGKDL
210 220 230 240 250
DKDEEFQKFI SVPENREYVY GDTATLLDKK LPKSNWLAMW IFLGAIAVVA
260 270 280 290 300
LLGADSDLRP SFGGKPLSMV LVIQMFMLLT GALIIILTKT NPASISKNEV
310 320 330 340 350
FRSGMIAIVA VYGIAWMAET MFGAHMSEIQ GVLGEMVKEY PWAYAIVLLL
360 370 380 390 400
VSKFVNSQAA ALAAIVPVAL AIGVDPAYIV ASAPACYGYY ILPTYPSDLA
410 420 430 440
AIQFDRSGTT HIGRFVINHS FILPGLIGVS VSCVFGWIFA AMYGFL
Length:446
Mass (Da):47,935
Last modified:November 8, 2005 - v1
Checksum:iB4AF89BB2E0CCB3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79886 Genomic DNA. Translation: CAA56258.1.
U14003 Genomic DNA. Translation: AAA97023.1.
U00096 Genomic DNA. Translation: AAC77084.1.
AP009048 Genomic DNA. Translation: BAE78125.1.
M27058 Genomic DNA. Translation: AAA23826.1.
PIRiS56352.
RefSeqiNP_418547.1. NC_000913.3.
WP_000899522.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77084; AAC77084; b4123.
BAE78125; BAE78125; BAE78125.
GeneIDi948641.
KEGGiecj:JW4084.
eco:b4123.
PATRICi32123811. VBIEscCol129921_4254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79886 Genomic DNA. Translation: CAA56258.1.
U14003 Genomic DNA. Translation: AAA97023.1.
U00096 Genomic DNA. Translation: AAC77084.1.
AP009048 Genomic DNA. Translation: BAE78125.1.
M27058 Genomic DNA. Translation: AAA23826.1.
PIRiS56352.
RefSeqiNP_418547.1. NC_000913.3.
WP_000899522.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ABN9.
SMRiP0ABN9. Positions 335-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260911. 9 interactions.
STRINGi511145.b4123.

Protein family/group databases

TCDBi2.A.13.1.2. the c4-dicarboxylate uptake (dcu) family.

Proteomic databases

PaxDbiP0ABN9.
PRIDEiP0ABN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77084; AAC77084; b4123.
BAE78125; BAE78125; BAE78125.
GeneIDi948641.
KEGGiecj:JW4084.
eco:b4123.
PATRICi32123811. VBIEscCol129921_4254.

Organism-specific databases

EchoBASEiEB0006.
EcoGeneiEG10006. dcuB.

Phylogenomic databases

eggNOGiENOG4105DS2. Bacteria.
COG2704. LUCA.
HOGENOMiHOG000272417.
InParanoidiP0ABN9.
KOiK07792.
OMAiDKDPEFQ.
PhylomeDBiP0ABN9.

Enzyme and pathway databases

BioCyciEcoCyc:DCUB-MONOMER.
ECOL316407:JW4084-MONOMER.
MetaCyc:DCUB-MONOMER.

Miscellaneous databases

PROiP0ABN9.

Family and domain databases

InterProiIPR004668. Anaer_Dcu_memb_transpt.
[Graphical view]
PfamiPF03605. DcuA_DcuB. 1 hit.
[Graphical view]
PIRSFiPIRSF004539. C4-dicrbxl_trns. 1 hit.
TIGRFAMsiTIGR00770. Dcu. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCUB_ECOLI
AccessioniPrimary (citable) accession number: P0ABN9
Secondary accession number(s): P14409, Q2M6I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.