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Protein

Anaerobic C4-dicarboxylate transporter DcuB

Gene

dcuB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane.

GO - Molecular functioni

  • C4-dicarboxylate transmembrane transporter activity Source: EcoCyc
  • succinate:fumarate antiporter activity Source: EcoCyc

GO - Biological processi

  • C4-dicarboxylate transport Source: EcoCyc

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:DCUB-MONOMER
MetaCyc:DCUB-MONOMER

Protein family/group databases

TCDBi2.A.13.1.2 the c4-dicarboxylate uptake (dcu) family

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic C4-dicarboxylate transporter DcuB
Gene namesi
Name:dcuB
Synonyms:genF
Ordered Locus Names:b4123, JW4084
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10006 dcuB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 19HelicalBy similarityAdd BLAST19
Topological domaini20CytoplasmicBy similarity1
Transmembranei21 – 39HelicalBy similarityAdd BLAST19
Topological domaini40 – 55PeriplasmicBy similarityAdd BLAST16
Transmembranei56 – 73HelicalBy similarityAdd BLAST18
Topological domaini74 – 87CytoplasmicBy similarityAdd BLAST14
Transmembranei88 – 105HelicalBy similarityAdd BLAST18
Topological domaini106 – 134PeriplasmicBy similarityAdd BLAST29
Transmembranei135 – 149HelicalBy similarityAdd BLAST15
Topological domaini150 – 240CytoplasmicBy similarityAdd BLAST91
Transmembranei241 – 258HelicalBy similarityAdd BLAST18
Topological domaini259 – 275PeriplasmicBy similarityAdd BLAST17
Transmembranei276 – 293HelicalBy similarityAdd BLAST18
Topological domaini294 – 303CytoplasmicBy similarity10
Transmembranei304 – 321HelicalBy similarityAdd BLAST18
Topological domaini322 – 343PeriplasmicBy similarityAdd BLAST22
Transmembranei344 – 361HelicalBy similarityAdd BLAST18
Topological domaini362 – 366CytoplasmicBy similarity5
Transmembranei367 – 384HelicalBy similarityAdd BLAST18
Topological domaini385 – 446PeriplasmicBy similarityAdd BLAST62

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001703551 – 446Anaerobic C4-dicarboxylate transporter DcuBAdd BLAST446

Proteomic databases

PaxDbiP0ABN9
PRIDEiP0ABN9

Interactioni

Protein-protein interaction databases

BioGridi4260911, 9 interactors
STRINGi316385.ECDH10B_4315

Structurei

3D structure databases

ProteinModelPortaliP0ABN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DS2 Bacteria
COG2704 LUCA
HOGENOMiHOG000272417
InParanoidiP0ABN9
KOiK07792
OMAiDKDPEFQ
PhylomeDBiP0ABN9

Family and domain databases

InterProiView protein in InterPro
IPR004668 Anaer_Dcu_memb_transpt
PANTHERiPTHR36106 PTHR36106, 1 hit
PfamiView protein in Pfam
PF03605 DcuA_DcuB, 1 hit
PIRSFiPIRSF004539 C4-dicrbxl_trns, 1 hit
TIGRFAMsiTIGR00770 Dcu, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFTIQLIII LICLFYGARK GGIALGLLGG IGLVILVFVF HLQPGKPPVD
60 70 80 90 100
VMLVIIAVVA ASATLQASGG LDVMLQIAEK LLRRNPKYVS IVAPFVTCTL
110 120 130 140 150
TILCGTGHVV YTILPIIYDV AIKNNIRPER PMAASSIGAQ MGIIASPVSV
160 170 180 190 200
AVVSLVAMLG NVTFDGRHLE FLDLLAITIP STLIGILAIG IFSWFRGKDL
210 220 230 240 250
DKDEEFQKFI SVPENREYVY GDTATLLDKK LPKSNWLAMW IFLGAIAVVA
260 270 280 290 300
LLGADSDLRP SFGGKPLSMV LVIQMFMLLT GALIIILTKT NPASISKNEV
310 320 330 340 350
FRSGMIAIVA VYGIAWMAET MFGAHMSEIQ GVLGEMVKEY PWAYAIVLLL
360 370 380 390 400
VSKFVNSQAA ALAAIVPVAL AIGVDPAYIV ASAPACYGYY ILPTYPSDLA
410 420 430 440
AIQFDRSGTT HIGRFVINHS FILPGLIGVS VSCVFGWIFA AMYGFL
Length:446
Mass (Da):47,935
Last modified:November 8, 2005 - v1
Checksum:iB4AF89BB2E0CCB3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79886 Genomic DNA Translation: CAA56258.1
U14003 Genomic DNA Translation: AAA97023.1
U00096 Genomic DNA Translation: AAC77084.1
AP009048 Genomic DNA Translation: BAE78125.1
M27058 Genomic DNA Translation: AAA23826.1
PIRiS56352
RefSeqiNP_418547.1, NC_000913.3
WP_000899522.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77084; AAC77084; b4123
BAE78125; BAE78125; BAE78125
GeneIDi948641
KEGGiecj:JW4084
eco:b4123
PATRICifig|1411691.4.peg.2577

Similar proteinsi

Entry informationi

Entry nameiDCUB_ECOLI
AccessioniPrimary (citable) accession number: P0ABN9
Secondary accession number(s): P14409, Q2M6I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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