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P0ABN4

- KDGL_SHIFL

UniProt

P0ABN4 - KDGL_SHIFL

Protein

Diacylglycerol kinase

Gene

dgkA

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Recycling of diacylglycerol produced during the turnover of membrane phospholipid.By similarity

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. diacylglycerol kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. phospholipid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol kinase (EC:2.7.1.107)
    Short name:
    DAGK
    Alternative name(s):
    Diglyceride kinase
    Short name:
    DGK
    Gene namesi
    Name:dgkA
    Ordered Locus Names:SF4163, S3568
    OrganismiShigella flexneri
    Taxonomic identifieri623 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 122121Diacylglycerol kinasePRO_0000195268Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198214.SF4163.

    Structurei

    3D structure databases

    ProteinModelPortaliP0ABN4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 3332CytoplasmicCuratedAdd
    BLAST
    Topological domaini50 – 523PeriplasmicCurated
    Topological domaini70 – 9526CytoplasmicCuratedAdd
    BLAST
    Topological domaini120 – 1223PeriplasmicCurated

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 4916HelicalCuratedAdd
    BLAST
    Transmembranei53 – 6917HelicalCuratedAdd
    BLAST
    Transmembranei96 – 11924HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0818.
    HOGENOMiHOG000014819.
    KOiK00901.
    OMAiFKNTSYA.
    OrthoDBiEOG60W7XM.

    Family and domain databases

    InterProiIPR000829. Diacylglycerol_kinase_prok.
    [Graphical view]
    PfamiPF01219. DAGK_prokar. 1 hit.
    [Graphical view]
    PROSITEiPS01069. DAGK_PROKAR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0ABN4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANNTTGFTR IIKAAGYSWK GLRAAWINEA AFRQEGVAVL LAVVIACWLD    50
    VDAITRVLLI SSVMLVMIVE ILNSAIEAVV DRIGSEYHEL SGRAKDMGSA 100
    AVLIAIIVAV ITWCILLWSH FG 122
    Length:122
    Mass (Da):13,245
    Last modified:January 23, 2007 - v2
    Checksum:iD5B4F86925FA6A17
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN45585.1.
    AE014073 Genomic DNA. Translation: AAP18614.1.
    RefSeqiNP_709878.1. NC_004337.2.
    NP_838803.1. NC_004741.1.

    Genome annotation databases

    EnsemblBacteriaiAAN45585; AAN45585; SF4163.
    AAP18614; AAP18614; S3568.
    GeneIDi1023428.
    1079787.
    KEGGisfl:SF4163.
    sfx:S3568.
    PATRICi18708912. VBIShiFle31049_3894.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN45585.1 .
    AE014073 Genomic DNA. Translation: AAP18614.1 .
    RefSeqi NP_709878.1. NC_004337.2.
    NP_838803.1. NC_004741.1.

    3D structure databases

    ProteinModelPortali P0ABN4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198214.SF4163.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN45585 ; AAN45585 ; SF4163 .
    AAP18614 ; AAP18614 ; S3568 .
    GeneIDi 1023428.
    1079787.
    KEGGi sfl:SF4163.
    sfx:S3568.
    PATRICi 18708912. VBIShiFle31049_3894.

    Phylogenomic databases

    eggNOGi COG0818.
    HOGENOMi HOG000014819.
    KOi K00901.
    OMAi FKNTSYA.
    OrthoDBi EOG60W7XM.

    Family and domain databases

    InterProi IPR000829. Diacylglycerol_kinase_prok.
    [Graphical view ]
    Pfami PF01219. DAGK_prokar. 1 hit.
    [Graphical view ]
    PROSITEi PS01069. DAGK_PROKAR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
      Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
      , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
      Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 301 / Serotype 2a.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700930 / 2457T / Serotype 2a.

    Entry informationi

    Entry nameiKDGL_SHIFL
    AccessioniPrimary (citable) accession number: P0ABN4
    Secondary accession number(s): P00556
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3