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Protein

Diacylglycerol kinase

Gene

dgkA

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Recycling of diacylglycerol produced during the turnover of membrane phospholipid.By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase (EC:2.7.1.107)
Short name:
DAGK
Alternative name(s):
Diglyceride kinase
Short name:
DGK
Gene namesi
Name:dgkA
Ordered Locus Names:SF4163, S3568
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3332CytoplasmicCuratedAdd
BLAST
Transmembranei34 – 4916HelicalCuratedAdd
BLAST
Topological domaini50 – 523PeriplasmicCurated
Transmembranei53 – 6917HelicalCuratedAdd
BLAST
Topological domaini70 – 9526CytoplasmicCuratedAdd
BLAST
Transmembranei96 – 11924HelicalCuratedAdd
BLAST
Topological domaini120 – 1223PeriplasmicCurated

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 122121Diacylglycerol kinasePRO_0000195268Add
BLAST

Proteomic databases

PaxDbiP0ABN4.

Interactioni

Protein-protein interaction databases

STRINGi198214.SF4163.

Structurei

3D structure databases

ProteinModelPortaliP0ABN4.
SMRiP0ABN4. Positions 7-121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41080IJ. Bacteria.
COG0818. LUCA.
HOGENOMiHOG000014819.
KOiK00901.
OMAiITNEWHE.

Family and domain databases

CDDicd14264. DAGK_IM. 1 hit.
InterProiIPR000829. DAGK.
IPR033718. DAGK_prok.
[Graphical view]
PfamiPF01219. DAGK_prokar. 1 hit.
[Graphical view]
PROSITEiPS01069. DAGK_PROKAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ABN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANNTTGFTR IIKAAGYSWK GLRAAWINEA AFRQEGVAVL LAVVIACWLD
60 70 80 90 100
VDAITRVLLI SSVMLVMIVE ILNSAIEAVV DRIGSEYHEL SGRAKDMGSA
110 120
AVLIAIIVAV ITWCILLWSH FG
Length:122
Mass (Da):13,245
Last modified:January 23, 2007 - v2
Checksum:iD5B4F86925FA6A17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN45585.1.
AE014073 Genomic DNA. Translation: AAP18614.1.
RefSeqiNP_709878.1. NC_004337.2.
WP_000002907.1. NZ_LM651928.1.

Genome annotation databases

EnsemblBacteriaiAAN45585; AAN45585; SF4163.
AAP18614; AAP18614; S3568.
GeneIDi1023428.
KEGGisfl:SF4163.
sft:NCTC1_04526.
sfx:S3568.
PATRICi18708912. VBIShiFle31049_3894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN45585.1.
AE014073 Genomic DNA. Translation: AAP18614.1.
RefSeqiNP_709878.1. NC_004337.2.
WP_000002907.1. NZ_LM651928.1.

3D structure databases

ProteinModelPortaliP0ABN4.
SMRiP0ABN4. Positions 7-121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF4163.

Proteomic databases

PaxDbiP0ABN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN45585; AAN45585; SF4163.
AAP18614; AAP18614; S3568.
GeneIDi1023428.
KEGGisfl:SF4163.
sft:NCTC1_04526.
sfx:S3568.
PATRICi18708912. VBIShiFle31049_3894.

Phylogenomic databases

eggNOGiENOG41080IJ. Bacteria.
COG0818. LUCA.
HOGENOMiHOG000014819.
KOiK00901.
OMAiITNEWHE.

Family and domain databases

CDDicd14264. DAGK_IM. 1 hit.
InterProiIPR000829. DAGK.
IPR033718. DAGK_prok.
[Graphical view]
PfamiPF01219. DAGK_prokar. 1 hit.
[Graphical view]
PROSITEiPS01069. DAGK_PROKAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKDGL_SHIFL
AccessioniPrimary (citable) accession number: P0ABN4
Secondary accession number(s): P00556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.