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P0ABN3

- KDGL_ECO57

UniProt

P0ABN3 - KDGL_ECO57

Protein

Diacylglycerol kinase

Gene

dgkA

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Recycling of diacylglycerol produced during the turnover of membrane phospholipid.By similarity

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. diacylglycerol kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. phospholipid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-5028-MONOMER.
    ECOO157:DGKA-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol kinase (EC:2.7.1.107)
    Short name:
    DAGK
    Alternative name(s):
    Diglyceride kinase
    Short name:
    DGK
    Gene namesi
    Name:dgkA
    Ordered Locus Names:Z5641, ECs5025
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 122121Diacylglycerol kinasePRO_0000195261Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi155864.Z5641.

    Structurei

    3D structure databases

    ProteinModelPortaliP0ABN3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 3332CytoplasmicBy similarityAdd
    BLAST
    Topological domaini50 – 523PeriplasmicBy similarity
    Topological domaini70 – 9526CytoplasmicBy similarityAdd
    BLAST
    Topological domaini120 – 1223PeriplasmicBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 4916HelicalBy similarityAdd
    BLAST
    Transmembranei53 – 6917HelicalBy similarityAdd
    BLAST
    Transmembranei96 – 11924HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0818.
    HOGENOMiHOG000014819.
    KOiK00901.
    OMAiFKNTSYA.
    OrthoDBiEOG60W7XM.

    Family and domain databases

    InterProiIPR000829. Diacylglycerol_kinase_prok.
    [Graphical view]
    PfamiPF01219. DAGK_prokar. 1 hit.
    [Graphical view]
    PROSITEiPS01069. DAGK_PROKAR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0ABN3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANNTTGFTR IIKAAGYSWK GLRAAWINEA AFRQEGVAVL LAVVIACWLD    50
    VDAITRVLLI SSVMLVMIVE ILNSAIEAVV DRIGSEYHEL SGRAKDMGSA 100
    AVLIAIIVAV ITWCILLWSH FG 122
    Length:122
    Mass (Da):13,245
    Last modified:January 23, 2007 - v2
    Checksum:iD5B4F86925FA6A17
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG59241.1.
    BA000007 Genomic DNA. Translation: BAB38448.1.
    PIRiA91257.
    E86097.
    RefSeqiNP_290676.1. NC_002655.2.
    NP_313052.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG59241; AAG59241; Z5641.
    BAB38448; BAB38448; BAB38448.
    GeneIDi914310.
    960081.
    KEGGiece:Z5641.
    ecs:ECs5025.
    PATRICi18359645. VBIEscCol44059_4959.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG59241.1 .
    BA000007 Genomic DNA. Translation: BAB38448.1 .
    PIRi A91257.
    E86097.
    RefSeqi NP_290676.1. NC_002655.2.
    NP_313052.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali P0ABN3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z5641.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG59241 ; AAG59241 ; Z5641 .
    BAB38448 ; BAB38448 ; BAB38448 .
    GeneIDi 914310.
    960081.
    KEGGi ece:Z5641.
    ecs:ECs5025.
    PATRICi 18359645. VBIEscCol44059_4959.

    Phylogenomic databases

    eggNOGi COG0818.
    HOGENOMi HOG000014819.
    KOi K00901.
    OMAi FKNTSYA.
    OrthoDBi EOG60W7XM.

    Enzyme and pathway databases

    BioCyci ECOL386585:GJFA-5028-MONOMER.
    ECOO157:DGKA-MONOMER.

    Family and domain databases

    InterProi IPR000829. Diacylglycerol_kinase_prok.
    [Graphical view ]
    Pfami PF01219. DAGK_prokar. 1 hit.
    [Graphical view ]
    PROSITEi PS01069. DAGK_PROKAR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiKDGL_ECO57
    AccessioniPrimary (citable) accession number: P0ABN3
    Secondary accession number(s): P00556
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3