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P0ABN3

- KDGL_ECO57

UniProt

P0ABN3 - KDGL_ECO57

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Protein
Diacylglycerol kinase
Gene
dgkA, Z5641, ECs5025
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Recycling of diacylglycerol produced during the turnover of membrane phospholipid By similarity.

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. phospholipid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECOL386585:GJFA-5028-MONOMER.
ECOO157:DGKA-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase (EC:2.7.1.107)
Short name:
DAGK
Alternative name(s):
Diglyceride kinase
Short name:
DGK
Gene namesi
Name:dgkA
Ordered Locus Names:Z5641, ECs5025
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3332Cytoplasmic By similarity
Add
BLAST
Transmembranei34 – 4916Helical; By similarity
Add
BLAST
Topological domaini50 – 523Periplasmic By similarity
Transmembranei53 – 6917Helical; By similarity
Add
BLAST
Topological domaini70 – 9526Cytoplasmic By similarity
Add
BLAST
Transmembranei96 – 11924Helical; By similarity
Add
BLAST
Topological domaini120 – 1223Periplasmic By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 122121Diacylglycerol kinase
PRO_0000195261Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi155864.Z5641.

Structurei

3D structure databases

ProteinModelPortaliP0ABN3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0818.
HOGENOMiHOG000014819.
KOiK00901.
OMAiFKNTSYA.
OrthoDBiEOG60W7XM.

Family and domain databases

InterProiIPR000829. Diacylglycerol_kinase_prok.
[Graphical view]
PfamiPF01219. DAGK_prokar. 1 hit.
[Graphical view]
PROSITEiPS01069. DAGK_PROKAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ABN3-1 [UniParc]FASTAAdd to Basket

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MANNTTGFTR IIKAAGYSWK GLRAAWINEA AFRQEGVAVL LAVVIACWLD    50
VDAITRVLLI SSVMLVMIVE ILNSAIEAVV DRIGSEYHEL SGRAKDMGSA 100
AVLIAIIVAV ITWCILLWSH FG 122
Length:122
Mass (Da):13,245
Last modified:January 23, 2007 - v2
Checksum:iD5B4F86925FA6A17
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG59241.1.
BA000007 Genomic DNA. Translation: BAB38448.1.
PIRiA91257.
E86097.
RefSeqiNP_290676.1. NC_002655.2.
NP_313052.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG59241; AAG59241; Z5641.
BAB38448; BAB38448; BAB38448.
GeneIDi914310.
960081.
KEGGiece:Z5641.
ecs:ECs5025.
PATRICi18359645. VBIEscCol44059_4959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG59241.1 .
BA000007 Genomic DNA. Translation: BAB38448.1 .
PIRi A91257.
E86097.
RefSeqi NP_290676.1. NC_002655.2.
NP_313052.1. NC_002695.1.

3D structure databases

ProteinModelPortali P0ABN3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 155864.Z5641.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG59241 ; AAG59241 ; Z5641 .
BAB38448 ; BAB38448 ; BAB38448 .
GeneIDi 914310.
960081.
KEGGi ece:Z5641.
ecs:ECs5025.
PATRICi 18359645. VBIEscCol44059_4959.

Phylogenomic databases

eggNOGi COG0818.
HOGENOMi HOG000014819.
KOi K00901.
OMAi FKNTSYA.
OrthoDBi EOG60W7XM.

Enzyme and pathway databases

BioCyci ECOL386585:GJFA-5028-MONOMER.
ECOO157:DGKA-MONOMER.

Family and domain databases

InterProi IPR000829. Diacylglycerol_kinase_prok.
[Graphical view ]
Pfami PF01219. DAGK_prokar. 1 hit.
[Graphical view ]
PROSITEi PS01069. DAGK_PROKAR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiKDGL_ECO57
AccessioniPrimary (citable) accession number: P0ABN3
Secondary accession number(s): P00556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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