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Protein

Diacylglycerol kinase

Gene

dgkA

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Recycling of diacylglycerol produced during the turnover of membrane phospholipid.By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECOL199310:C5013-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase (EC:2.7.1.107)
Short name:
DAGK
Alternative name(s):
Diglyceride kinase
Short name:
DGK
Gene namesi
Name:dgkA
Ordered Locus Names:c5013
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001410 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 33CytoplasmicBy similarityAdd BLAST32
Transmembranei34 – 49HelicalBy similarityAdd BLAST16
Topological domaini50 – 52PeriplasmicBy similarity3
Transmembranei53 – 69HelicalBy similarityAdd BLAST17
Topological domaini70 – 95CytoplasmicBy similarityAdd BLAST26
Transmembranei96 – 119HelicalBy similarityAdd BLAST24
Topological domaini120 – 122PeriplasmicBy similarity3

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001952622 – 122Diacylglycerol kinaseAdd BLAST121

Interactioni

Protein-protein interaction databases

STRINGi199310.c5013.

Structurei

3D structure databases

ProteinModelPortaliP0ABN2.
SMRiP0ABN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41080IJ. Bacteria.
COG0818. LUCA.
HOGENOMiHOG000014819.
KOiK00901.
OMAiITNEWHE.

Family and domain databases

CDDicd14264. DAGK_IM. 1 hit.
InterProiIPR000829. DAGK.
IPR033718. DAGK_prok.
[Graphical view]
PfamiPF01219. DAGK_prokar. 1 hit.
[Graphical view]
PROSITEiPS01069. DAGK_PROKAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ABN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANNTTGFTR IIKAAGYSWK GLRAAWINEA AFRQEGVAVL LAVVIACWLD
60 70 80 90 100
VDAITRVLLI SSVMLVMIVE ILNSAIEAVV DRIGSEYHEL SGRAKDMGSA
110 120
AVLIAIIVAV ITWCILLWSH FG
Length:122
Mass (Da):13,245
Last modified:January 23, 2007 - v2
Checksum:iD5B4F86925FA6A17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN83439.1.
RefSeqiWP_000002907.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN83439; AAN83439; c5013.
KEGGiecc:c5013.
PATRICi18287718. VBIEscCol75197_4705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN83439.1.
RefSeqiWP_000002907.1. NC_004431.1.

3D structure databases

ProteinModelPortaliP0ABN2.
SMRiP0ABN2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi199310.c5013.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN83439; AAN83439; c5013.
KEGGiecc:c5013.
PATRICi18287718. VBIEscCol75197_4705.

Phylogenomic databases

eggNOGiENOG41080IJ. Bacteria.
COG0818. LUCA.
HOGENOMiHOG000014819.
KOiK00901.
OMAiITNEWHE.

Enzyme and pathway databases

BioCyciECOL199310:C5013-MONOMER.

Family and domain databases

CDDicd14264. DAGK_IM. 1 hit.
InterProiIPR000829. DAGK.
IPR033718. DAGK_prok.
[Graphical view]
PfamiPF01219. DAGK_prokar. 1 hit.
[Graphical view]
PROSITEiPS01069. DAGK_PROKAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKDGL_ECOL6
AccessioniPrimary (citable) accession number: P0ABN2
Secondary accession number(s): P00556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.