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Protein

Cytochrome c-type biogenesis protein CcmH

Gene

ccmH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431Heme (covalent)Sequence analysis
Binding sitei46 – 461Heme (covalent)Sequence analysis

GO - Molecular functioni

GO - Biological processi

  • cytochrome complex assembly Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12052-MONOMER.
ECOL316407:JW2182-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type biogenesis protein CcmH
Gene namesi
Name:ccmH
Synonyms:yejP
Ordered Locus Names:b2194, JW2182
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12052. ccmH.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 9678PeriplasmicSequence analysisAdd
BLAST
Transmembranei97 – 11923HelicalSequence analysisAdd
BLAST
Topological domaini120 – 14627CytoplasmicSequence analysisAdd
BLAST
Transmembranei147 – 16923HelicalSequence analysisAdd
BLAST
Topological domaini170 – 350181PeriplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intrinsic component of periplasmic side of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 350332Cytochrome c-type biogenesis protein CcmHPRO_0000006612Add
BLAST

Proteomic databases

PaxDbiP0ABM9.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ccmFP339273EBI-560309,EBI-763370

Protein-protein interaction databases

BioGridi4260481. 8 interactions.
DIPiDIP-48146N.
IntActiP0ABM9. 4 interactions.
MINTiMINT-225097.
STRINGi511145.b2194.

Structurei

3D structure databases

ProteinModelPortaliP0ABM9.
SMRiP0ABM9. Positions 19-99, 195-286, 289-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati222 – 25534TPR 1Add
BLAST
Repeati293 – 32634TPR 2Add
BLAST

Sequence similaritiesi

Belongs to the CcmH/CycL/Ccl2/NrfF family.Curated
Contains 2 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105KWW. Bacteria.
COG3088. LUCA.
COG4235. LUCA.
HOGENOMiHOG000274683.
KOiK02200.
OMAiGYVAYLP.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR005616. CcmH/CycL/Ccl2/NrfF.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF03918. CcmH. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ABM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFLLGVLML MISGSALATI DVLQFKDEAQ EQQFRQLTEE LRCPKCQNNS
60 70 80 90 100
IADSNSMIAT DLRQKVYELM QEGKSKKEIV DYMVARYGNF VTYDPPLTPL
110 120 130 140 150
TVLLWVLPVV AIGIGGWVIY ARSRRRVRVV PEAFPEQSVP EGKRAGYVVY
160 170 180 190 200
LPGIVVALIV AGVSYYQTGN YQQVKIWQQA TAQAPALLDR ALDPKADPLN
210 220 230 240 250
EEEMSRLALG MRTQLQKNPG DIEGWIMLGR VGMALGNASI ATDAYATAYR
260 270 280 290 300
LDPKNSDAAL GYAEALTRSS DPNDNRLGGE LLRQLVRTDH SNIRVLSMYA
310 320 330 340 350
FNAFEQQRFG EAVAAWEMML KLLPANDTRR AVIERSIAQA MQHLSPQESK
Length:350
Mass (Da):39,089
Last modified:November 8, 2005 - v1
Checksum:i002126A1F17F493F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA. Translation: AAA16386.1.
U00096 Genomic DNA. Translation: AAC75254.1.
AP009048 Genomic DNA. Translation: BAE76657.1.
PIRiH64988.
RefSeqiNP_416698.1. NC_000913.3.
WP_001211575.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75254; AAC75254; b2194.
BAE76657; BAE76657; BAE76657.
GeneIDi946623.
KEGGiecj:JW2182.
eco:b2194.
PATRICi32119747. VBIEscCol129921_2283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA. Translation: AAA16386.1.
U00096 Genomic DNA. Translation: AAC75254.1.
AP009048 Genomic DNA. Translation: BAE76657.1.
PIRiH64988.
RefSeqiNP_416698.1. NC_000913.3.
WP_001211575.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ABM9.
SMRiP0ABM9. Positions 19-99, 195-286, 289-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260481. 8 interactions.
DIPiDIP-48146N.
IntActiP0ABM9. 4 interactions.
MINTiMINT-225097.
STRINGi511145.b2194.

Proteomic databases

PaxDbiP0ABM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75254; AAC75254; b2194.
BAE76657; BAE76657; BAE76657.
GeneIDi946623.
KEGGiecj:JW2182.
eco:b2194.
PATRICi32119747. VBIEscCol129921_2283.

Organism-specific databases

EchoBASEiEB1983.
EcoGeneiEG12052. ccmH.

Phylogenomic databases

eggNOGiENOG4105KWW. Bacteria.
COG3088. LUCA.
COG4235. LUCA.
HOGENOMiHOG000274683.
KOiK02200.
OMAiGYVAYLP.

Enzyme and pathway databases

BioCyciEcoCyc:EG12052-MONOMER.
ECOL316407:JW2182-MONOMER.

Miscellaneous databases

PROiP0ABM9.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR005616. CcmH/CycL/Ccl2/NrfF.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF03918. CcmH. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCMH_ECOLI
AccessioniPrimary (citable) accession number: P0ABM9
Secondary accession number(s): P33925, Q2MAP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.