Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c-type biogenesis protein CcmH

Gene

ccmH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43Heme (covalent)Sequence analysis1
Binding sitei46Heme (covalent)Sequence analysis1

GO - Molecular functioni

GO - Biological processi

  • cytochrome complex assembly Source: EcoCyc

Keywordsi

Biological processCytochrome c-type biogenesis
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12052-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type biogenesis protein CcmH
Gene namesi
Name:ccmH
Synonyms:yejP
Ordered Locus Names:b2194, JW2182
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12052 ccmH

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 96PeriplasmicSequence analysisAdd BLAST78
Transmembranei97 – 119HelicalSequence analysisAdd BLAST23
Topological domaini120 – 146CytoplasmicSequence analysisAdd BLAST27
Transmembranei147 – 169HelicalSequence analysisAdd BLAST23
Topological domaini170 – 350PeriplasmicSequence analysisAdd BLAST181

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intrinsic component of periplasmic side of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000661219 – 350Cytochrome c-type biogenesis protein CcmHAdd BLAST332

Proteomic databases

PaxDbiP0ABM9
PRIDEiP0ABM9

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ccmFP339273EBI-560309,EBI-763370

Protein-protein interaction databases

BioGridi4260481, 13 interactors
DIPiDIP-48146N
IntActiP0ABM9, 5 interactors
MINTiP0ABM9
STRINGi316385.ECDH10B_2351

Structurei

3D structure databases

ProteinModelPortaliP0ABM9
SMRiP0ABM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati222 – 255TPR 1Add BLAST34
Repeati293 – 326TPR 2Add BLAST34

Sequence similaritiesi

Belongs to the CcmH/CycL/Ccl2/NrfF family.Curated

Keywords - Domaini

Repeat, Signal, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105KWW Bacteria
COG3088 LUCA
COG4235 LUCA
HOGENOMiHOG000274683
KOiK02200
OMAiGYVAYLP

Family and domain databases

Gene3Di1.10.8.640, 1 hit
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR005616 CcmH/CycL/Ccl2/NrfF
IPR038297 CcmH/CycL/NrfF/Ccl2_sf
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF03918 CcmH, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ABM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFLLGVLML MISGSALATI DVLQFKDEAQ EQQFRQLTEE LRCPKCQNNS
60 70 80 90 100
IADSNSMIAT DLRQKVYELM QEGKSKKEIV DYMVARYGNF VTYDPPLTPL
110 120 130 140 150
TVLLWVLPVV AIGIGGWVIY ARSRRRVRVV PEAFPEQSVP EGKRAGYVVY
160 170 180 190 200
LPGIVVALIV AGVSYYQTGN YQQVKIWQQA TAQAPALLDR ALDPKADPLN
210 220 230 240 250
EEEMSRLALG MRTQLQKNPG DIEGWIMLGR VGMALGNASI ATDAYATAYR
260 270 280 290 300
LDPKNSDAAL GYAEALTRSS DPNDNRLGGE LLRQLVRTDH SNIRVLSMYA
310 320 330 340 350
FNAFEQQRFG EAVAAWEMML KLLPANDTRR AVIERSIAQA MQHLSPQESK
Length:350
Mass (Da):39,089
Last modified:November 8, 2005 - v1
Checksum:i002126A1F17F493F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA Translation: AAA16386.1
U00096 Genomic DNA Translation: AAC75254.1
AP009048 Genomic DNA Translation: BAE76657.1
PIRiH64988
RefSeqiNP_416698.1, NC_000913.3
WP_001211575.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75254; AAC75254; b2194
BAE76657; BAE76657; BAE76657
GeneIDi946623
KEGGiecj:JW2182
eco:b2194
PATRICifig|1411691.4.peg.42

Similar proteinsi

Entry informationi

Entry nameiCCMH_ECOLI
AccessioniPrimary (citable) accession number: P0ABM9
Secondary accession number(s): P33925, Q2MAP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health