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Protein

Heme exporter protein D

Gene

ccmD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.Curated

GO - Biological processi

  • cytochrome complex assembly Source: UniProtKB-KW
  • heme transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG12169-MONOMER.
ECOL316407:JW2186-MONOMER.
MetaCyc:EG12169-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme exporter protein D
Alternative name(s):
Cytochrome c-type biogenesis protein CcmD
Gene namesi
Name:ccmD
Synonyms:yojM
Ordered Locus Names:b2198, JW2186
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12169. ccmD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3720HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6969Heme exporter protein DPRO_0000201563Add
BLAST

Proteomic databases

PaxDbiP0ABM5.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ccmCP0ABM14EBI-3894922,EBI-2123469

Protein-protein interaction databases

BioGridi4260484. 9 interactions.
IntActiP0ABM5. 2 interactions.
STRINGi511145.b2198.

Structurei

3D structure databases

ProteinModelPortaliP0ABM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmD/CycX/HelD family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105X3C. Bacteria.
COG3114. LUCA.
HOGENOMiHOG000274648.
KOiK02196.
OMAiQQMENTL.

Family and domain databases

InterProiIPR007078. Haem_export_protD_CcmD.
[Graphical view]
PfamiPF04995. CcmD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03141. cytochro_ccmD. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPAFASWNE FFAMGGYAFF VWLAVVMTVI PLVVLVVHSV MQHRAILRGV
60
AQQRAREARL RAAQQQEAA
Length:69
Mass (Da):7,745
Last modified:November 8, 2005 - v1
Checksum:iBEC1D341EEADA018
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA. Translation: AAA16390.1.
U00096 Genomic DNA. Translation: AAC75258.1.
AP009048 Genomic DNA. Translation: BAE76661.1.
PIRiD64989.
RefSeqiNP_416702.1. NC_000913.3.
WP_000186540.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75258; AAC75258; b2198.
BAE76661; BAE76661; BAE76661.
GeneIDi946709.
KEGGiecj:JW2186.
eco:b2198.
PATRICi32119755. VBIEscCol129921_2287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA. Translation: AAA16390.1.
U00096 Genomic DNA. Translation: AAC75258.1.
AP009048 Genomic DNA. Translation: BAE76661.1.
PIRiD64989.
RefSeqiNP_416702.1. NC_000913.3.
WP_000186540.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ABM5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260484. 9 interactions.
IntActiP0ABM5. 2 interactions.
STRINGi511145.b2198.

Proteomic databases

PaxDbiP0ABM5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75258; AAC75258; b2198.
BAE76661; BAE76661; BAE76661.
GeneIDi946709.
KEGGiecj:JW2186.
eco:b2198.
PATRICi32119755. VBIEscCol129921_2287.

Organism-specific databases

EchoBASEiEB2088.
EcoGeneiEG12169. ccmD.

Phylogenomic databases

eggNOGiENOG4105X3C. Bacteria.
COG3114. LUCA.
HOGENOMiHOG000274648.
KOiK02196.
OMAiQQMENTL.

Enzyme and pathway databases

BioCyciEcoCyc:EG12169-MONOMER.
ECOL316407:JW2186-MONOMER.
MetaCyc:EG12169-MONOMER.

Miscellaneous databases

PROiP0ABM5.

Family and domain databases

InterProiIPR007078. Haem_export_protD_CcmD.
[Graphical view]
PfamiPF04995. CcmD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03141. cytochro_ccmD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCMD_ECOLI
AccessioniPrimary (citable) accession number: P0ABM5
Secondary accession number(s): P36770, Q2MAP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.