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Protein

Heme exporter protein C

Gene

ccmC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CCMC-MONOMER.
ECOL316407:JW2187-MONOMER.
MetaCyc:CCMC-MONOMER.

Protein family/group databases

TCDBi9.B.14.2.3. the putative heme handling protein (hhp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme exporter protein C
Alternative name(s):
Cytochrome c-type biogenesis protein CcmC
Gene namesi
Name:ccmC
Synonyms:yejT, yejU
Ordered Locus Names:b2199, JW2187
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12057. ccmC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence analysisAdd
BLAST
Transmembranei21 – 4121HelicalSequence analysisAdd
BLAST
Topological domaini42 – 6322PeriplasmicSequence analysisAdd
BLAST
Transmembranei64 – 8421HelicalSequence analysisAdd
BLAST
Topological domaini85 – 906CytoplasmicSequence analysis
Transmembranei91 – 11121HelicalSequence analysisAdd
BLAST
Topological domaini112 – 12817PeriplasmicSequence analysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence analysisAdd
BLAST
Topological domaini150 – 15910CytoplasmicSequence analysis
Transmembranei160 – 18021HelicalSequence analysisAdd
BLAST
Topological domaini181 – 20525PeriplasmicSequence analysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence analysisAdd
BLAST
Topological domaini227 – 24519CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Heme exporter protein CPRO_0000201551Add
BLAST

Proteomic databases

PaxDbiP0ABM1.
PRIDEiP0ABM1.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ccmDP0ABM54EBI-2123469,EBI-3894922
ccmEP694906EBI-2123469,EBI-1128007

Protein-protein interaction databases

BioGridi4263174. 20 interactions.
IntActiP0ABM1. 4 interactions.
MINTiMINT-1503327.
STRINGi511145.b2199.

Structurei

3D structure databases

ProteinModelPortaliP0ABM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmC/CycZ/HelC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41060IM. Bacteria.
COG0755. LUCA.
HOGENOMiHOG000274637.
InParanoidiP0ABM1.
KOiK02195.
OMAiPSIATPM.
PhylomeDBiP0ABM1.

Family and domain databases

InterProiIPR002541. Cyt_c_assembly.
IPR003557. Cyt_c_biogenesis_CcmC.
[Graphical view]
PfamiPF01578. Cytochrom_C_asm. 1 hit.
[Graphical view]
PRINTSiPR01386. CCMCBIOGNSIS.
TIGRFAMsiTIGR01191. ccmC. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKTLHQLAI PPRLYQICGW FIPWLAIASV VVLTVGWIWG FGFAPADYQQ
60 70 80 90 100
GNSYRIIYLH VPAAIWSMGI YASMAVAAFI GLVWQMKMAN LAVAAMAPIG
110 120 130 140 150
AVFTFIALVT GSAWGKPMWG TWWVWDARLT SELVLLFLYV GVIALWHAFD
160 170 180 190 200
DRRLAGRAAG ILVLIGVVNL PIIHYSVEWW NTLHQGSTRM QQSIDPAMRS
210 220 230 240
PLRWSIFGFL LLSATLTLMR MRNLILLMEK RRPWVSELIL KRGRK
Length:245
Mass (Da):27,885
Last modified:November 8, 2005 - v1
Checksum:iA98F2F754948EA60
GO

Sequence cautioni

The sequence AAA16391 differs from that shown. Reason: Frameshift at position 156. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA. Translation: AAA16391.1. Frameshift.
U00096 Genomic DNA. Translation: AAC75259.1.
AP009048 Genomic DNA. Translation: BAE76662.1.
PIRiE64989.
RefSeqiNP_416703.1. NC_000913.3.
WP_001295447.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75259; AAC75259; b2199.
BAE76662; BAE76662; BAE76662.
GeneIDi946703.
KEGGiecj:JW2187.
eco:b2199.
PATRICi32119757. VBIEscCol129921_2288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA. Translation: AAA16391.1. Frameshift.
U00096 Genomic DNA. Translation: AAC75259.1.
AP009048 Genomic DNA. Translation: BAE76662.1.
PIRiE64989.
RefSeqiNP_416703.1. NC_000913.3.
WP_001295447.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ABM1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263174. 20 interactions.
IntActiP0ABM1. 4 interactions.
MINTiMINT-1503327.
STRINGi511145.b2199.

Protein family/group databases

TCDBi9.B.14.2.3. the putative heme handling protein (hhp) family.

Proteomic databases

PaxDbiP0ABM1.
PRIDEiP0ABM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75259; AAC75259; b2199.
BAE76662; BAE76662; BAE76662.
GeneIDi946703.
KEGGiecj:JW2187.
eco:b2199.
PATRICi32119757. VBIEscCol129921_2288.

Organism-specific databases

EchoBASEiEB1987.
EcoGeneiEG12057. ccmC.

Phylogenomic databases

eggNOGiENOG41060IM. Bacteria.
COG0755. LUCA.
HOGENOMiHOG000274637.
InParanoidiP0ABM1.
KOiK02195.
OMAiPSIATPM.
PhylomeDBiP0ABM1.

Enzyme and pathway databases

BioCyciEcoCyc:CCMC-MONOMER.
ECOL316407:JW2187-MONOMER.
MetaCyc:CCMC-MONOMER.

Miscellaneous databases

PROiP0ABM1.

Family and domain databases

InterProiIPR002541. Cyt_c_assembly.
IPR003557. Cyt_c_biogenesis_CcmC.
[Graphical view]
PfamiPF01578. Cytochrom_C_asm. 1 hit.
[Graphical view]
PRINTSiPR01386. CCMCBIOGNSIS.
TIGRFAMsiTIGR01191. ccmC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCMC_ECOLI
AccessioniPrimary (citable) accession number: P0ABM1
Secondary accession number(s): P33929, Q2MAP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.