Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heme exporter protein C

Gene

ccmC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCytochrome c-type biogenesis, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CCMC-MONOMER
MetaCyc:CCMC-MONOMER

Protein family/group databases

TCDBi9.B.14.2.3 the putative heme handling protein (hhp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Heme exporter protein C
Alternative name(s):
Cytochrome c-type biogenesis protein CcmC
Gene namesi
Name:ccmC
Synonyms:yejT, yejU
Ordered Locus Names:b2199, JW2187
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12057 ccmC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42 – 63PeriplasmicSequence analysisAdd BLAST22
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 90CytoplasmicSequence analysis6
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 128PeriplasmicSequence analysisAdd BLAST17
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Topological domaini150 – 159CytoplasmicSequence analysis10
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 205PeriplasmicSequence analysisAdd BLAST25
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 245CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002015511 – 245Heme exporter protein CAdd BLAST245

Proteomic databases

PaxDbiP0ABM1
PRIDEiP0ABM1

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi4263174, 20 interactors
IntActiP0ABM1, 4 interactors
MINTiP0ABM1
STRINGi316385.ECDH10B_2356

Structurei

3D structure databases

ProteinModelPortaliP0ABM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmC/CycZ/HelC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41060IM Bacteria
COG0755 LUCA
HOGENOMiHOG000274637
InParanoidiP0ABM1
KOiK02195
OMAiFHVPMWF
PhylomeDBiP0ABM1

Family and domain databases

InterProiView protein in InterPro
IPR002541 Cyt_c_assembly
IPR003557 Cyt_c_biogenesis_CcmC
PfamiView protein in Pfam
PF01578 Cytochrom_C_asm, 1 hit
PRINTSiPR01386 CCMCBIOGNSIS
TIGRFAMsiTIGR01191 ccmC, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKTLHQLAI PPRLYQICGW FIPWLAIASV VVLTVGWIWG FGFAPADYQQ
60 70 80 90 100
GNSYRIIYLH VPAAIWSMGI YASMAVAAFI GLVWQMKMAN LAVAAMAPIG
110 120 130 140 150
AVFTFIALVT GSAWGKPMWG TWWVWDARLT SELVLLFLYV GVIALWHAFD
160 170 180 190 200
DRRLAGRAAG ILVLIGVVNL PIIHYSVEWW NTLHQGSTRM QQSIDPAMRS
210 220 230 240
PLRWSIFGFL LLSATLTLMR MRNLILLMEK RRPWVSELIL KRGRK
Length:245
Mass (Da):27,885
Last modified:November 8, 2005 - v1
Checksum:iA98F2F754948EA60
GO

Sequence cautioni

The sequence AAA16391 differs from that shown. Reason: Frameshift at position 156.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA Translation: AAA16391.1 Frameshift.
U00096 Genomic DNA Translation: AAC75259.1
AP009048 Genomic DNA Translation: BAE76662.1
PIRiE64989
RefSeqiNP_416703.1, NC_000913.3
WP_001295447.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75259; AAC75259; b2199
BAE76662; BAE76662; BAE76662
GeneIDi946703
KEGGiecj:JW2187
eco:b2199
PATRICifig|1411691.4.peg.37

Similar proteinsi

Entry informationi

Entry nameiCCMC_ECOLI
AccessioniPrimary (citable) accession number: P0ABM1
Secondary accession number(s): P33929, Q2MAP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health