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P0ABL8 (CCMB_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heme exporter protein B
Alternative name(s):
Cytochrome c-type biogenesis protein CcmB
Gene names
Name:ccmB
Synonyms:yejV
Ordered Locus Names:b2200, JW2188
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

Subcellular location

Cell inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the CcmB/CycW/HelB family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Heme exporter protein B
PRO_0000201539

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4121Helical; Potential
Topological domain42 – 443Periplasmic Potential
Transmembrane45 – 6521Helical; Potential
Topological domain66 – 10035Cytoplasmic Potential
Transmembrane101 – 12121Helical; Potential
Topological domain122 – 1276Periplasmic Potential
Transmembrane128 – 14821Helical; Potential
Topological domain149 – 15810Cytoplasmic Potential
Transmembrane159 – 17921Helical; Potential
Topological domain180 – 19213Periplasmic Potential
Transmembrane193 – 21321Helical; Potential
Topological domain214 – 2207Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P0ABL8 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 8DC1EEB8168401A3

FASTA22023,619
        10         20         30         40         50         60 
MMFWRIFRLE LRVAFRHSAE IANPLWFFLI VITLFPLSIG PEPQLLARIA PGIIWVAALL 

        70         80         90        100        110        120 
SSLLALERLF RDDLQDGSLE QLMLLPLPLP AVVLAKVMAH WMVTGLPLLI LSPLVAMLLG 

       130        140        150        160        170        180 
MDVYGWQVMA LTLLLGTPTL GFLGAPGVAL TVGLKRGGVL LSILVLPLTI PLLIFATAAM 

       190        200        210        220 
DAASMHLPVD GYLAILGALL AGTATLSPFA TAAALRISIQ 

« Hide

References

« Hide 'large scale' references
[1]"Automated multiplex sequencing of the E.coli genome."
Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K., Church G.M.
Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / BHB2600.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Escherichia coli genes required for cytochrome c maturation."
Thoeny-Meyer L., Fischer F., Kunzler P., Ritz D., Hennecke H.
J. Bacteriol. 177:4321-4326(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, GENE NAME.
[5]"Global topology analysis of the Escherichia coli inner membrane proteome."
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: K12 / MG1655 / ATCC 47076.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00008 Genomic DNA. Translation: AAA16392.1.
U00096 Genomic DNA. Translation: AAC75260.1.
AP009048 Genomic DNA. Translation: BAE76663.1.
PIRF64989.
RefSeqNP_416704.1. NC_000913.3.
YP_490438.1. NC_007779.1.

3D structure databases

ProteinModelPortalP0ABL8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-48046N.
IntActP0ABL8. 9 interactions.
MINTMINT-1250139.
STRING511145.b2200.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC75260; AAC75260; b2200.
BAE76663; BAE76663; BAE76663.
GeneID12931491.
946692.
KEGGecj:Y75_p2161.
eco:b2200.
PATRIC32119759. VBIEscCol129921_2289.

Organism-specific databases

EchoBASEEB1988.
EcoGeneEG12058. ccmB.

Phylogenomic databases

eggNOGCOG2386.
HOGENOMHOG000274626.
KOK02194.
OMATGHLLWL.
OrthoDBEOG64FKHN.
PhylomeDBP0ABL8.

Enzyme and pathway databases

BioCycEcoCyc:CCMB-MONOMER.
ECOL316407:JW2188-MONOMER.
MetaCyc:CCMB-MONOMER.

Gene expression databases

GenevestigatorP0ABL8.

Family and domain databases

InterProIPR003544. Cyt_c_biogenesis_CcmB.
IPR026031. Cyt_c_CcmB_bac.
[Graphical view]
PfamPF03379. CcmB. 1 hit.
[Graphical view]
PIRSFPIRSF002764. CcmB. 1 hit.
PRINTSPR01414. CCMBBIOGNSIS.
TIGRFAMsTIGR01190. ccmB. 1 hit.
ProtoNetSearch...

Other

PROP0ABL8.

Entry information

Entry nameCCMB_ECOLI
AccessionPrimary (citable) accession number: P0ABL8
Secondary accession number(s): P33930, Q2MAP3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene