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Protein

Heme exporter protein B

Gene

ccmB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

GO - Molecular functioni

  • ATPase activity, coupled Source: EcoCyc
  • heme transporter activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CCMB-MONOMER.
ECOL316407:JW2188-MONOMER.
MetaCyc:CCMB-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme exporter protein B
Alternative name(s):
Cytochrome c-type biogenesis protein CcmB
Gene namesi
Name:ccmB
Synonyms:yejV
Ordered Locus Names:b2200, JW2188
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12058. ccmB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42 – 44PeriplasmicSequence analysis3
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 100CytoplasmicSequence analysisAdd BLAST35
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 127PeriplasmicSequence analysis6
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 158CytoplasmicSequence analysis10
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 192PeriplasmicSequence analysisAdd BLAST13
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 220CytoplasmicSequence analysis7

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002015391 – 220Heme exporter protein BAdd BLAST220

Proteomic databases

PaxDbiP0ABL8.
PRIDEiP0ABL8.

Interactioni

Protein-protein interaction databases

BioGridi4260485. 8 interactors.
DIPiDIP-48046N.
IntActiP0ABL8. 9 interactors.
MINTiMINT-1250139.
STRINGi511145.b2200.

Structurei

3D structure databases

ProteinModelPortaliP0ABL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmB/CycW/HelB family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CA5. Bacteria.
COG2386. LUCA.
HOGENOMiHOG000274626.
InParanoidiP0ABL8.
KOiK02194.
OMAiGPAIVWI.
PhylomeDBiP0ABL8.

Family and domain databases

InterProiIPR003544. Cyt_c_biogenesis_CcmB.
IPR026031. Cyt_c_CcmB_bac.
[Graphical view]
PANTHERiPTHR30070:SF1. PTHR30070:SF1. 1 hit.
PfamiPF03379. CcmB. 1 hit.
[Graphical view]
PIRSFiPIRSF002764. CcmB. 1 hit.
PRINTSiPR01414. CCMBBIOGNSIS.
TIGRFAMsiTIGR01190. ccmB. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFWRIFRLE LRVAFRHSAE IANPLWFFLI VITLFPLSIG PEPQLLARIA
60 70 80 90 100
PGIIWVAALL SSLLALERLF RDDLQDGSLE QLMLLPLPLP AVVLAKVMAH
110 120 130 140 150
WMVTGLPLLI LSPLVAMLLG MDVYGWQVMA LTLLLGTPTL GFLGAPGVAL
160 170 180 190 200
TVGLKRGGVL LSILVLPLTI PLLIFATAAM DAASMHLPVD GYLAILGALL
210 220
AGTATLSPFA TAAALRISIQ
Length:220
Mass (Da):23,619
Last modified:November 8, 2005 - v1
Checksum:i8DC1EEB8168401A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA. Translation: AAA16392.1.
U00096 Genomic DNA. Translation: AAC75260.1.
AP009048 Genomic DNA. Translation: BAE76663.1.
PIRiF64989.
RefSeqiNP_416704.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC75260; AAC75260; b2200.
BAE76663; BAE76663; BAE76663.
GeneIDi946692.
KEGGiecj:JW2188.
eco:b2200.
PATRICi32119759. VBIEscCol129921_2289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA. Translation: AAA16392.1.
U00096 Genomic DNA. Translation: AAC75260.1.
AP009048 Genomic DNA. Translation: BAE76663.1.
PIRiF64989.
RefSeqiNP_416704.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP0ABL8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260485. 8 interactors.
DIPiDIP-48046N.
IntActiP0ABL8. 9 interactors.
MINTiMINT-1250139.
STRINGi511145.b2200.

Proteomic databases

PaxDbiP0ABL8.
PRIDEiP0ABL8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75260; AAC75260; b2200.
BAE76663; BAE76663; BAE76663.
GeneIDi946692.
KEGGiecj:JW2188.
eco:b2200.
PATRICi32119759. VBIEscCol129921_2289.

Organism-specific databases

EchoBASEiEB1988.
EcoGeneiEG12058. ccmB.

Phylogenomic databases

eggNOGiENOG4105CA5. Bacteria.
COG2386. LUCA.
HOGENOMiHOG000274626.
InParanoidiP0ABL8.
KOiK02194.
OMAiGPAIVWI.
PhylomeDBiP0ABL8.

Enzyme and pathway databases

BioCyciEcoCyc:CCMB-MONOMER.
ECOL316407:JW2188-MONOMER.
MetaCyc:CCMB-MONOMER.

Miscellaneous databases

PROiP0ABL8.

Family and domain databases

InterProiIPR003544. Cyt_c_biogenesis_CcmB.
IPR026031. Cyt_c_CcmB_bac.
[Graphical view]
PANTHERiPTHR30070:SF1. PTHR30070:SF1. 1 hit.
PfamiPF03379. CcmB. 1 hit.
[Graphical view]
PIRSFiPIRSF002764. CcmB. 1 hit.
PRINTSiPR01414. CCMBBIOGNSIS.
TIGRFAMsiTIGR01190. ccmB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCMB_ECOLI
AccessioniPrimary (citable) accession number: P0ABL8
Secondary accession number(s): P33930, Q2MAP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.