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P0ABL8

- CCMB_ECOLI

UniProt

P0ABL8 - CCMB_ECOLI

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Protein

Heme exporter protein B

Gene

ccmB

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

GO - Molecular functioni

  1. heme-transporting ATPase activity Source: EcoCyc

GO - Biological processi

  1. cytochrome complex assembly Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CCMB-MONOMER.
ECOL316407:JW2188-MONOMER.
MetaCyc:CCMB-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme exporter protein B
Alternative name(s):
Cytochrome c-type biogenesis protein CcmB
Gene namesi
Name:ccmB
Synonyms:yejV
Ordered Locus Names:b2200, JW2188
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG12058. ccmB.

Subcellular locationi

GO - Cellular componenti

  1. ATP-binding cassette (ABC) transporter complex Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Heme exporter protein BPRO_0000201539Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP0ABL8.

Interactioni

Protein-protein interaction databases

DIPiDIP-48046N.
IntActiP0ABL8. 9 interactions.
MINTiMINT-1250139.
STRINGi511145.b2200.

Structurei

3D structure databases

ProteinModelPortaliP0ABL8.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini42 – 443PeriplasmicSequence Analysis
Topological domaini66 – 10035CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini122 – 1276PeriplasmicSequence Analysis
Topological domaini149 – 15810CytoplasmicSequence Analysis
Topological domaini180 – 19213PeriplasmicSequence AnalysisAdd
BLAST
Topological domaini214 – 2207CytoplasmicSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence AnalysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence AnalysisAdd
BLAST
Transmembranei128 – 14821HelicalSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Transmembranei193 – 21321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmB/CycW/HelB family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2386.
HOGENOMiHOG000274626.
InParanoidiP0ABL8.
KOiK02194.
OMAiTGHLLWL.
OrthoDBiEOG64FKHN.
PhylomeDBiP0ABL8.

Family and domain databases

InterProiIPR003544. Cyt_c_biogenesis_CcmB.
IPR026031. Cyt_c_CcmB_bac.
[Graphical view]
PfamiPF03379. CcmB. 1 hit.
[Graphical view]
PIRSFiPIRSF002764. CcmB. 1 hit.
PRINTSiPR01414. CCMBBIOGNSIS.
TIGRFAMsiTIGR01190. ccmB. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABL8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMFWRIFRLE LRVAFRHSAE IANPLWFFLI VITLFPLSIG PEPQLLARIA
60 70 80 90 100
PGIIWVAALL SSLLALERLF RDDLQDGSLE QLMLLPLPLP AVVLAKVMAH
110 120 130 140 150
WMVTGLPLLI LSPLVAMLLG MDVYGWQVMA LTLLLGTPTL GFLGAPGVAL
160 170 180 190 200
TVGLKRGGVL LSILVLPLTI PLLIFATAAM DAASMHLPVD GYLAILGALL
210 220
AGTATLSPFA TAAALRISIQ
Length:220
Mass (Da):23,619
Last modified:November 8, 2005 - v1
Checksum:i8DC1EEB8168401A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00008 Genomic DNA. Translation: AAA16392.1.
U00096 Genomic DNA. Translation: AAC75260.1.
AP009048 Genomic DNA. Translation: BAE76663.1.
PIRiF64989.
RefSeqiNP_416704.1. NC_000913.3.
YP_490438.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75260; AAC75260; b2200.
BAE76663; BAE76663; BAE76663.
GeneIDi12931491.
946692.
KEGGiecj:Y75_p2161.
eco:b2200.
PATRICi32119759. VBIEscCol129921_2289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00008 Genomic DNA. Translation: AAA16392.1 .
U00096 Genomic DNA. Translation: AAC75260.1 .
AP009048 Genomic DNA. Translation: BAE76663.1 .
PIRi F64989.
RefSeqi NP_416704.1. NC_000913.3.
YP_490438.1. NC_007779.1.

3D structure databases

ProteinModelPortali P0ABL8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-48046N.
IntActi P0ABL8. 9 interactions.
MINTi MINT-1250139.
STRINGi 511145.b2200.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC75260 ; AAC75260 ; b2200 .
BAE76663 ; BAE76663 ; BAE76663 .
GeneIDi 12931491.
946692.
KEGGi ecj:Y75_p2161.
eco:b2200.
PATRICi 32119759. VBIEscCol129921_2289.

Organism-specific databases

EchoBASEi EB1988.
EcoGenei EG12058. ccmB.

Phylogenomic databases

eggNOGi COG2386.
HOGENOMi HOG000274626.
InParanoidi P0ABL8.
KOi K02194.
OMAi TGHLLWL.
OrthoDBi EOG64FKHN.
PhylomeDBi P0ABL8.

Enzyme and pathway databases

BioCyci EcoCyc:CCMB-MONOMER.
ECOL316407:JW2188-MONOMER.
MetaCyc:CCMB-MONOMER.

Miscellaneous databases

PROi P0ABL8.

Gene expression databases

Genevestigatori P0ABL8.

Family and domain databases

InterProi IPR003544. Cyt_c_biogenesis_CcmB.
IPR026031. Cyt_c_CcmB_bac.
[Graphical view ]
Pfami PF03379. CcmB. 1 hit.
[Graphical view ]
PIRSFi PIRSF002764. CcmB. 1 hit.
PRINTSi PR01414. CCMBBIOGNSIS.
TIGRFAMsi TIGR01190. ccmB. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Automated multiplex sequencing of the E.coli genome."
    Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K., Church G.M.
    Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / BHB2600.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Escherichia coli genes required for cytochrome c maturation."
    Thoeny-Meyer L., Fischer F., Kunzler P., Ritz D., Hennecke H.
    J. Bacteriol. 177:4321-4326(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, GENE NAME.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiCCMB_ECOLI
AccessioniPrimary (citable) accession number: P0ABL8
Secondary accession number(s): P33930, Q2MAP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3