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Protein

Heme exporter protein B

Gene

ccmB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

GO - Molecular functioni

  • ATPase activity, coupled Source: EcoCyc
  • heme transporter activity Source: InterPro

GO - Biological processi

Keywordsi

Biological processCytochrome c-type biogenesis, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CCMB-MONOMER
MetaCyc:CCMB-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Heme exporter protein B
Alternative name(s):
Cytochrome c-type biogenesis protein CcmB
Gene namesi
Name:ccmB
Synonyms:yejV
Ordered Locus Names:b2200, JW2188
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12058 ccmB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42 – 44PeriplasmicSequence analysis3
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 100CytoplasmicSequence analysisAdd BLAST35
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 127PeriplasmicSequence analysis6
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 158CytoplasmicSequence analysis10
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 192PeriplasmicSequence analysisAdd BLAST13
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 220CytoplasmicSequence analysis7

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002015391 – 220Heme exporter protein BAdd BLAST220

Proteomic databases

PaxDbiP0ABL8
PRIDEiP0ABL8

Interactioni

Protein-protein interaction databases

BioGridi4260485, 8 interactors
DIPiDIP-48046N
IntActiP0ABL8, 9 interactors
STRINGi316385.ECDH10B_2357

Structurei

3D structure databases

ProteinModelPortaliP0ABL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmB/CycW/HelB family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CA5 Bacteria
COG2386 LUCA
HOGENOMiHOG000274626
InParanoidiP0ABL8
KOiK02194
OMAiGPAIVWI
PhylomeDBiP0ABL8

Family and domain databases

InterProiView protein in InterPro
IPR003544 Cyt_c_biogenesis_CcmB
IPR026031 Cyt_c_CcmB_bac
PANTHERiPTHR30070 PTHR30070, 1 hit
PfamiView protein in Pfam
PF03379 CcmB, 1 hit
PIRSFiPIRSF002764 CcmB, 1 hit
TIGRFAMsiTIGR01190 ccmB, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFWRIFRLE LRVAFRHSAE IANPLWFFLI VITLFPLSIG PEPQLLARIA
60 70 80 90 100
PGIIWVAALL SSLLALERLF RDDLQDGSLE QLMLLPLPLP AVVLAKVMAH
110 120 130 140 150
WMVTGLPLLI LSPLVAMLLG MDVYGWQVMA LTLLLGTPTL GFLGAPGVAL
160 170 180 190 200
TVGLKRGGVL LSILVLPLTI PLLIFATAAM DAASMHLPVD GYLAILGALL
210 220
AGTATLSPFA TAAALRISIQ
Length:220
Mass (Da):23,619
Last modified:November 8, 2005 - v1
Checksum:i8DC1EEB8168401A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA Translation: AAA16392.1
U00096 Genomic DNA Translation: AAC75260.1
AP009048 Genomic DNA Translation: BAE76663.1
PIRiF64989
RefSeqiNP_416704.1, NC_000913.3
WP_000971730.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75260; AAC75260; b2200
BAE76663; BAE76663; BAE76663
GeneIDi946692
KEGGiecj:JW2188
eco:b2200
PATRICifig|1411691.4.peg.36

Similar proteinsi

Entry informationi

Entry nameiCCMB_ECOLI
AccessioniPrimary (citable) accession number: P0ABL8
Secondary accession number(s): P33930, Q2MAP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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