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P0ABL8

- CCMB_ECOLI

UniProt

P0ABL8 - CCMB_ECOLI

Protein

Heme exporter protein B

Gene

ccmB

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

    GO - Molecular functioni

    1. heme-transporting ATPase activity Source: EcoCyc

    GO - Biological processi

    1. cytochrome complex assembly Source: UniProtKB-KW

    Keywords - Biological processi

    Cytochrome c-type biogenesis, Transport

    Enzyme and pathway databases

    BioCyciEcoCyc:CCMB-MONOMER.
    ECOL316407:JW2188-MONOMER.
    MetaCyc:CCMB-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heme exporter protein B
    Alternative name(s):
    Cytochrome c-type biogenesis protein CcmB
    Gene namesi
    Name:ccmB
    Synonyms:yejV
    Ordered Locus Names:b2200, JW2188
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG12058. ccmB.

    Subcellular locationi

    GO - Cellular componenti

    1. ATP-binding cassette (ABC) transporter complex Source: EcoCyc

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220Heme exporter protein BPRO_0000201539Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP0ABL8.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-48046N.
    IntActiP0ABL8. 9 interactions.
    MINTiMINT-1250139.
    STRINGi511145.b2200.

    Structurei

    3D structure databases

    ProteinModelPortaliP0ABL8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini42 – 443PeriplasmicSequence Analysis
    Topological domaini66 – 10035CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini122 – 1276PeriplasmicSequence Analysis
    Topological domaini149 – 15810CytoplasmicSequence Analysis
    Topological domaini180 – 19213PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini214 – 2207CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei193 – 21321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CcmB/CycW/HelB family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2386.
    HOGENOMiHOG000274626.
    KOiK02194.
    OMAiTGHLLWL.
    OrthoDBiEOG64FKHN.
    PhylomeDBiP0ABL8.

    Family and domain databases

    InterProiIPR003544. Cyt_c_biogenesis_CcmB.
    IPR026031. Cyt_c_CcmB_bac.
    [Graphical view]
    PfamiPF03379. CcmB. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002764. CcmB. 1 hit.
    PRINTSiPR01414. CCMBBIOGNSIS.
    TIGRFAMsiTIGR01190. ccmB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0ABL8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMFWRIFRLE LRVAFRHSAE IANPLWFFLI VITLFPLSIG PEPQLLARIA    50
    PGIIWVAALL SSLLALERLF RDDLQDGSLE QLMLLPLPLP AVVLAKVMAH 100
    WMVTGLPLLI LSPLVAMLLG MDVYGWQVMA LTLLLGTPTL GFLGAPGVAL 150
    TVGLKRGGVL LSILVLPLTI PLLIFATAAM DAASMHLPVD GYLAILGALL 200
    AGTATLSPFA TAAALRISIQ 220
    Length:220
    Mass (Da):23,619
    Last modified:November 8, 2005 - v1
    Checksum:i8DC1EEB8168401A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00008 Genomic DNA. Translation: AAA16392.1.
    U00096 Genomic DNA. Translation: AAC75260.1.
    AP009048 Genomic DNA. Translation: BAE76663.1.
    PIRiF64989.
    RefSeqiNP_416704.1. NC_000913.3.
    YP_490438.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC75260; AAC75260; b2200.
    BAE76663; BAE76663; BAE76663.
    GeneIDi12931491.
    946692.
    KEGGiecj:Y75_p2161.
    eco:b2200.
    PATRICi32119759. VBIEscCol129921_2289.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00008 Genomic DNA. Translation: AAA16392.1 .
    U00096 Genomic DNA. Translation: AAC75260.1 .
    AP009048 Genomic DNA. Translation: BAE76663.1 .
    PIRi F64989.
    RefSeqi NP_416704.1. NC_000913.3.
    YP_490438.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P0ABL8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-48046N.
    IntActi P0ABL8. 9 interactions.
    MINTi MINT-1250139.
    STRINGi 511145.b2200.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC75260 ; AAC75260 ; b2200 .
    BAE76663 ; BAE76663 ; BAE76663 .
    GeneIDi 12931491.
    946692.
    KEGGi ecj:Y75_p2161.
    eco:b2200.
    PATRICi 32119759. VBIEscCol129921_2289.

    Organism-specific databases

    EchoBASEi EB1988.
    EcoGenei EG12058. ccmB.

    Phylogenomic databases

    eggNOGi COG2386.
    HOGENOMi HOG000274626.
    KOi K02194.
    OMAi TGHLLWL.
    OrthoDBi EOG64FKHN.
    PhylomeDBi P0ABL8.

    Enzyme and pathway databases

    BioCyci EcoCyc:CCMB-MONOMER.
    ECOL316407:JW2188-MONOMER.
    MetaCyc:CCMB-MONOMER.

    Miscellaneous databases

    PROi P0ABL8.

    Gene expression databases

    Genevestigatori P0ABL8.

    Family and domain databases

    InterProi IPR003544. Cyt_c_biogenesis_CcmB.
    IPR026031. Cyt_c_CcmB_bac.
    [Graphical view ]
    Pfami PF03379. CcmB. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002764. CcmB. 1 hit.
    PRINTSi PR01414. CCMBBIOGNSIS.
    TIGRFAMsi TIGR01190. ccmB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Automated multiplex sequencing of the E.coli genome."
      Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K., Church G.M.
      Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / BHB2600.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. "Escherichia coli genes required for cytochrome c maturation."
      Thoeny-Meyer L., Fischer F., Kunzler P., Ritz D., Hennecke H.
      J. Bacteriol. 177:4321-4326(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, GENE NAME.
    5. "Global topology analysis of the Escherichia coli inner membrane proteome."
      Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
      Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: K12 / MG1655 / ATCC 47076.

    Entry informationi

    Entry nameiCCMB_ECOLI
    AccessioniPrimary (citable) accession number: P0ABL8
    Secondary accession number(s): P33930, Q2MAP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3