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Protein

Cytochrome c-type protein NapC

Gene

napC

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mediates electron flow from quinones to the NapAB complex.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57Heme 1 (covalent)By similarity1
Binding sitei60Heme 1 (covalent)By similarity1
Metal bindingi61Iron (heme 1 axial ligand)By similarity1
Binding sitei87Heme 2 (covalent)By similarity1
Binding sitei90Heme 2 (covalent)By similarity1
Metal bindingi91Iron (heme 2 axial ligand)By similarity1
Binding sitei147Heme 3 (covalent)By similarity1
Binding sitei150Heme 3 (covalent)By similarity1
Metal bindingi151Iron (heme 3 axial ligand)By similarity1
Binding sitei179Heme 4 (covalent)By similarity1
Binding sitei182Heme 4 (covalent)By similarity1
Metal bindingi183Iron (heme 4 axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciECOL199310:C2739-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type protein NapC
Gene namesi
Name:napC
Ordered Locus Names:c2739
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001410 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 200PeriplasmicSequence analysisAdd BLAST156

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001084341 – 200Cytochrome c-type protein NapCAdd BLAST200

Post-translational modificationi

Binds 4 heme groups per subunit.Curated

Interactioni

Protein-protein interaction databases

STRINGi199310.c2739.

Structurei

3D structure databases

ProteinModelPortaliP0ABL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CUW. Bacteria.
COG3005. LUCA.
HOGENOMiHOG000275532.
KOiK02569.
OMAiCTGCHEM.

Family and domain databases

InterProiIPR011031. Multihaem_cyt.
IPR024717. NapC/NirT/NrfH.
IPR005126. NapC/NirT_cyt_c_N.
IPR011885. NO3Rdtase_cyt_c_NapC/NirT.
[Graphical view]
PfamiPF03264. Cytochrom_NNT. 1 hit.
[Graphical view]
PIRSFiPIRSF000013. 4_hem_cytochrm_NapC. 1 hit.
SUPFAMiSSF48695. SSF48695. 1 hit.
TIGRFAMsiTIGR02161. napC_nirT. 1 hit.
PROSITEiPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ABL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSDRKPGL IKRLWKWWRT PSRLALGTLL LIGFVGGIVF WGGFNTGMEK
60 70 80 90 100
ANTEEFCISC HEMRNTVYQE YMDSVHYNNR SGVRATCPDC HVPHEFVPKM
110 120 130 140 150
IRKLKASKEL YGKIFGVIDT PQKFEAHRLT MAQNEWRRMK DNNSQECRNC
160 170 180 190 200
HNFEYMDTTA QKSVAAKMHD QAVKDGQTCI DCHKGIAHKL PDMREVEPGF
Length:200
Mass (Da):23,101
Last modified:November 8, 2005 - v1
Checksum:iE86A62ABE46AAAA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN81193.1.
RefSeqiWP_000528376.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN81193; AAN81193; c2739.
KEGGiecc:c2739.
PATRICi18283348. VBIEscCol75197_2581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN81193.1.
RefSeqiWP_000528376.1. NC_004431.1.

3D structure databases

ProteinModelPortaliP0ABL6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi199310.c2739.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN81193; AAN81193; c2739.
KEGGiecc:c2739.
PATRICi18283348. VBIEscCol75197_2581.

Phylogenomic databases

eggNOGiENOG4105CUW. Bacteria.
COG3005. LUCA.
HOGENOMiHOG000275532.
KOiK02569.
OMAiCTGCHEM.

Enzyme and pathway databases

BioCyciECOL199310:C2739-MONOMER.

Family and domain databases

InterProiIPR011031. Multihaem_cyt.
IPR024717. NapC/NirT/NrfH.
IPR005126. NapC/NirT_cyt_c_N.
IPR011885. NO3Rdtase_cyt_c_NapC/NirT.
[Graphical view]
PfamiPF03264. Cytochrom_NNT. 1 hit.
[Graphical view]
PIRSFiPIRSF000013. 4_hem_cytochrm_NapC. 1 hit.
SUPFAMiSSF48695. SSF48695. 1 hit.
TIGRFAMsiTIGR02161. napC_nirT. 1 hit.
PROSITEiPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAPC_ECOL6
AccessioniPrimary (citable) accession number: P0ABL6
Secondary accession number(s): P33932
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.