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Protein

Cytochrome c-type protein NapC

Gene

napC

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mediates electron flow from quinones to the NapAB complex.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571Heme 1 (covalent)By similarity
Binding sitei60 – 601Heme 1 (covalent)By similarity
Metal bindingi61 – 611Iron (heme 1 axial ligand)By similarity
Binding sitei87 – 871Heme 2 (covalent)By similarity
Binding sitei90 – 901Heme 2 (covalent)By similarity
Metal bindingi91 – 911Iron (heme 2 axial ligand)By similarity
Binding sitei147 – 1471Heme 3 (covalent)By similarity
Binding sitei150 – 1501Heme 3 (covalent)By similarity
Metal bindingi151 – 1511Iron (heme 3 axial ligand)By similarity
Binding sitei179 – 1791Heme 4 (covalent)By similarity
Binding sitei182 – 1821Heme 4 (covalent)By similarity
Metal bindingi183 – 1831Iron (heme 4 axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. denitrification pathway Source: InterPro
  2. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciECOL199310:C2739-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type protein NapC
Gene namesi
Name:napC
Ordered Locus Names:c2739
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001410: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei24 – 4421HelicalSequence AnalysisAdd
BLAST
Topological domaini45 – 200156PeriplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Cytochrome c-type protein NapCPRO_0000108434Add
BLAST

Post-translational modificationi

Binds 4 heme groups per subunit.Curated

Interactioni

Protein-protein interaction databases

STRINGi199310.c2739.

Structurei

3D structure databases

ProteinModelPortaliP0ABL6.
SMRiP0ABL6. Positions 29-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000275532.
KOiK02569.
OMAiCTGCHEM.
OrthoDBiEOG6RNQDS.

Family and domain databases

InterProiIPR011031. Multihaem_cyt.
IPR024717. NapC/NirT/NrfH.
IPR005126. NapC/NirT_cyt_c_N.
IPR011885. NO3Rdtase_cyt_c_NapC/NirT.
[Graphical view]
PfamiPF03264. Cytochrom_NNT. 1 hit.
[Graphical view]
PIRSFiPIRSF000013. 4_hem_cytochrm_NapC. 1 hit.
TIGRFAMsiTIGR02161. napC_nirT. 1 hit.
PROSITEiPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ABL6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNSDRKPGL IKRLWKWWRT PSRLALGTLL LIGFVGGIVF WGGFNTGMEK
60 70 80 90 100
ANTEEFCISC HEMRNTVYQE YMDSVHYNNR SGVRATCPDC HVPHEFVPKM
110 120 130 140 150
IRKLKASKEL YGKIFGVIDT PQKFEAHRLT MAQNEWRRMK DNNSQECRNC
160 170 180 190 200
HNFEYMDTTA QKSVAAKMHD QAVKDGQTCI DCHKGIAHKL PDMREVEPGF
Length:200
Mass (Da):23,101
Last modified:November 8, 2005 - v1
Checksum:iE86A62ABE46AAAA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN81193.1.
RefSeqiNP_754625.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN81193; AAN81193; c2739.
GeneIDi1038151.
KEGGiecc:c2739.
PATRICi18283348. VBIEscCol75197_2581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN81193.1.
RefSeqiNP_754625.1. NC_004431.1.

3D structure databases

ProteinModelPortaliP0ABL6.
SMRiP0ABL6. Positions 29-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi199310.c2739.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN81193; AAN81193; c2739.
GeneIDi1038151.
KEGGiecc:c2739.
PATRICi18283348. VBIEscCol75197_2581.

Phylogenomic databases

HOGENOMiHOG000275532.
KOiK02569.
OMAiCTGCHEM.
OrthoDBiEOG6RNQDS.

Enzyme and pathway databases

BioCyciECOL199310:C2739-MONOMER.

Family and domain databases

InterProiIPR011031. Multihaem_cyt.
IPR024717. NapC/NirT/NrfH.
IPR005126. NapC/NirT_cyt_c_N.
IPR011885. NO3Rdtase_cyt_c_NapC/NirT.
[Graphical view]
PfamiPF03264. Cytochrom_NNT. 1 hit.
[Graphical view]
PIRSFiPIRSF000013. 4_hem_cytochrm_NapC. 1 hit.
TIGRFAMsiTIGR02161. napC_nirT. 1 hit.
PROSITEiPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPEC.

Entry informationi

Entry nameiNAPC_ECOL6
AccessioniPrimary (citable) accession number: P0ABL6
Secondary accession number(s): P33932
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: January 7, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.