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Protein

Cytochrome c-type protein NapC

Gene

napC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates electron flow from quinones to the NapAB complex.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571Heme 1 (covalent)By similarity
Binding sitei60 – 601Heme 1 (covalent)By similarity
Metal bindingi61 – 611Iron (heme 1 axial ligand)By similarity
Binding sitei87 – 871Heme 2 (covalent)By similarity
Binding sitei90 – 901Heme 2 (covalent)By similarity
Metal bindingi91 – 911Iron (heme 2 axial ligand)By similarity
Binding sitei147 – 1471Heme 3 (covalent)By similarity
Binding sitei150 – 1501Heme 3 (covalent)By similarity
Metal bindingi151 – 1511Iron (heme 3 axial ligand)By similarity
Binding sitei179 – 1791Heme 4 (covalent)By similarity
Binding sitei182 – 1821Heme 4 (covalent)By similarity
Metal bindingi183 – 1831Iron (heme 4 axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

  • anaerobic respiration Source: EcoCyc
  • denitrification pathway Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:NAPC-MONOMER.
ECOL316407:JW2190-MONOMER.
MetaCyc:NAPC-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type protein NapC
Gene namesi
Name:napC
Synonyms:yejX
Ordered Locus Names:b2202, JW2190
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12060. napC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence analysisAdd
BLAST
Transmembranei24 – 4421HelicalSequence analysisAdd
BLAST
Topological domaini45 – 200156PeriplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Cytochrome c-type protein NapCPRO_0000108432Add
BLAST

Post-translational modificationi

Binds 4 heme groups per subunit.Curated

Proteomic databases

PaxDbiP0ABL5.
PRIDEiP0ABL5.

Interactioni

Protein-protein interaction databases

BioGridi4261930. 8 interactions.
DIPiDIP-10306N.
IntActiP0ABL5. 43 interactions.
STRINGi511145.b2202.

Structurei

3D structure databases

ProteinModelPortaliP0ABL5.
SMRiP0ABL5. Positions 29-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CUW. Bacteria.
COG3005. LUCA.
HOGENOMiHOG000275532.
InParanoidiP0ABL5.
KOiK02569.
OMAiCTGCHEM.
PhylomeDBiP0ABL5.

Family and domain databases

InterProiIPR011031. Multihaem_cyt.
IPR024717. NapC/NirT/NrfH.
IPR005126. NapC/NirT_cyt_c_N.
IPR011885. NO3Rdtase_cyt_c_NapC/NirT.
[Graphical view]
PfamiPF03264. Cytochrom_NNT. 1 hit.
[Graphical view]
PIRSFiPIRSF000013. 4_hem_cytochrm_NapC. 1 hit.
SUPFAMiSSF48695. SSF48695. 1 hit.
TIGRFAMsiTIGR02161. napC_nirT. 1 hit.
PROSITEiPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ABL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSDRKPGL IKRLWKWWRT PSRLALGTLL LIGFVGGIVF WGGFNTGMEK
60 70 80 90 100
ANTEEFCISC HEMRNTVYQE YMDSVHYNNR SGVRATCPDC HVPHEFVPKM
110 120 130 140 150
IRKLKASKEL YGKIFGVIDT PQKFEAHRLT MAQNEWRRMK DNNSQECRNC
160 170 180 190 200
HNFEYMDTTA QKSVAAKMHD QAVKDGQTCI DCHKGIAHKL PDMREVEPGF
Length:200
Mass (Da):23,101
Last modified:November 8, 2005 - v1
Checksum:iE86A62ABE46AAAA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA. Translation: AAA16394.1.
U00096 Genomic DNA. Translation: AAC75262.1.
AP009048 Genomic DNA. Translation: BAE76665.1.
PIRiH64989.
RefSeqiNP_416706.1. NC_000913.3.
WP_000528376.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75262; AAC75262; b2202.
BAE76665; BAE76665; BAE76665.
GeneIDi946706.
KEGGiecj:JW2190.
eco:b2202.
PATRICi32119763. VBIEscCol129921_2291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA. Translation: AAA16394.1.
U00096 Genomic DNA. Translation: AAC75262.1.
AP009048 Genomic DNA. Translation: BAE76665.1.
PIRiH64989.
RefSeqiNP_416706.1. NC_000913.3.
WP_000528376.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ABL5.
SMRiP0ABL5. Positions 29-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261930. 8 interactions.
DIPiDIP-10306N.
IntActiP0ABL5. 43 interactions.
STRINGi511145.b2202.

Proteomic databases

PaxDbiP0ABL5.
PRIDEiP0ABL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75262; AAC75262; b2202.
BAE76665; BAE76665; BAE76665.
GeneIDi946706.
KEGGiecj:JW2190.
eco:b2202.
PATRICi32119763. VBIEscCol129921_2291.

Organism-specific databases

EchoBASEiEB1990.
EcoGeneiEG12060. napC.

Phylogenomic databases

eggNOGiENOG4105CUW. Bacteria.
COG3005. LUCA.
HOGENOMiHOG000275532.
InParanoidiP0ABL5.
KOiK02569.
OMAiCTGCHEM.
PhylomeDBiP0ABL5.

Enzyme and pathway databases

BioCyciEcoCyc:NAPC-MONOMER.
ECOL316407:JW2190-MONOMER.
MetaCyc:NAPC-MONOMER.

Miscellaneous databases

PROiP0ABL5.

Family and domain databases

InterProiIPR011031. Multihaem_cyt.
IPR024717. NapC/NirT/NrfH.
IPR005126. NapC/NirT_cyt_c_N.
IPR011885. NO3Rdtase_cyt_c_NapC/NirT.
[Graphical view]
PfamiPF03264. Cytochrom_NNT. 1 hit.
[Graphical view]
PIRSFiPIRSF000013. 4_hem_cytochrm_NapC. 1 hit.
SUPFAMiSSF48695. SSF48695. 1 hit.
TIGRFAMsiTIGR02161. napC_nirT. 1 hit.
PROSITEiPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAPC_ECOLI
AccessioniPrimary (citable) accession number: P0ABL5
Secondary accession number(s): P33932, Q2MAP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.