Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c-type protein NapC

Gene

napC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates electron flow from quinones to the NapAB complex.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57Heme 1 (covalent)By similarity1
Binding sitei60Heme 1 (covalent)By similarity1
Metal bindingi63Iron (heme 1 axial ligand)By similarity1
Binding sitei87Heme 2 (covalent)By similarity1
Binding sitei90Heme 2 (covalent)By similarity1
Metal bindingi91Iron (heme 2 axial ligand); via tele nitrogenBy similarity1
Binding sitei103SubstrateBy similarity1
Metal bindingi109Iron (heme 1 axial ligand)By similarity1
Binding sitei147Heme 3 (covalent)By similarity1
Binding sitei150Heme 3 (covalent)By similarity1
Metal bindingi151Iron (heme 3 axial ligand); via tele nitrogenBy similarity1
Binding sitei179Heme 4 (covalent)By similarity1
Binding sitei182Heme 4 (covalent)By similarity1
Metal bindingi183Iron (heme 4 axial ligand); via tele nitrogenBy similarity1
Metal bindingi188Iron (heme 2 axial ligand); via tele nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

  • anaerobic respiration Source: EcoCyc
  • denitrification pathway Source: InterPro

Keywordsi

Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:NAPC-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type protein NapC
Gene namesi
Name:napC
Synonyms:yejX
Ordered Locus Names:b2202, JW2190
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12060 napC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 200PeriplasmicSequence analysisAdd BLAST156

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001084321 – 200Cytochrome c-type protein NapCAdd BLAST200

Post-translational modificationi

Binds 4 heme groups per subunit.Curated

Proteomic databases

PaxDbiP0ABL5
PRIDEiP0ABL5

Interactioni

Protein-protein interaction databases

BioGridi4261930, 10 interactors
DIPiDIP-10306N
IntActiP0ABL5, 43 interactors
STRINGi316385.ECDH10B_2359

Structurei

3D structure databases

ProteinModelPortaliP0ABL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CUW Bacteria
COG3005 LUCA
HOGENOMiHOG000275532
InParanoidiP0ABL5
KOiK02569
OMAiCTGCHEM
PhylomeDBiP0ABL5

Family and domain databases

Gene3Di1.10.3820.10, 1 hit
InterProiView protein in InterPro
IPR011031 Multihaem_cyt
IPR036280 Multihaem_cyt_sf
IPR024717 NapC/NirT/NrfH
IPR005126 NapC/NirT_cyt_c_N
IPR038266 NapC/NirT_cytc_sf
IPR011885 NO3Rdtase_cyt_c_NapC/NirT
PfamiView protein in Pfam
PF03264 Cytochrom_NNT, 1 hit
PIRSFiPIRSF000013 4_hem_cytochrm_NapC, 1 hit
SUPFAMiSSF48695 SSF48695, 1 hit
TIGRFAMsiTIGR02161 napC_nirT, 1 hit
PROSITEiView protein in PROSITE
PS51008 MULTIHEME_CYTC, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSDRKPGL IKRLWKWWRT PSRLALGTLL LIGFVGGIVF WGGFNTGMEK
60 70 80 90 100
ANTEEFCISC HEMRNTVYQE YMDSVHYNNR SGVRATCPDC HVPHEFVPKM
110 120 130 140 150
IRKLKASKEL YGKIFGVIDT PQKFEAHRLT MAQNEWRRMK DNNSQECRNC
160 170 180 190 200
HNFEYMDTTA QKSVAAKMHD QAVKDGQTCI DCHKGIAHKL PDMREVEPGF
Length:200
Mass (Da):23,101
Last modified:November 8, 2005 - v1
Checksum:iE86A62ABE46AAAA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA Translation: AAA16394.1
U00096 Genomic DNA Translation: AAC75262.1
AP009048 Genomic DNA Translation: BAE76665.1
PIRiH64989
RefSeqiNP_416706.1, NC_000913.3
WP_000528376.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75262; AAC75262; b2202
BAE76665; BAE76665; BAE76665
GeneIDi946706
KEGGiecj:JW2190
eco:b2202
PATRICifig|1411691.4.peg.34

Similar proteinsi

Entry informationi

Entry nameiNAPC_ECOLI
AccessioniPrimary (citable) accession number: P0ABL5
Secondary accession number(s): P33932, Q2MAP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health