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Protein

Minor curlin subunit

Gene

csgB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Curlin is the structural subunit of the curli fimbriae. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers. Coexpression of cellulose and thin aggregative fimbriae (curli fimbrae or fibers) leads to a hydrophobic network with tightly packed cells embedded in a highly inert matrix that confers cohesion, elasticity and tissue-like properties to colonies (PubMed:24097954).1 Publication

Miscellaneous

Cellulose production is abolished in E.coli K12 / MG1655 and W3110 due to a premature stop codon in bcsQ (PubMed:24097954).1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • amyloid fibril formation Source: EcoCyc
  • cell adhesion Source: EcoCyc
  • single-species biofilm formation Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:G6547-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Minor curlin subunit
Gene namesi
Name:csgB
Ordered Locus Names:b1041, JW1024
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12621 csgB

Subcellular locationi

  • Fimbrium
  • Note: Part of the curli surface structure.

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • pilus Source: EcoCyc

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Disruption phenotypei

When disrupted in a cellulose-synthesizing strain (with a functional bcsQ gene), cellulose is made but colony morphology indicates no curli are made.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000637422 – 151Minor curlin subunitAdd BLAST130

Proteomic databases

PaxDbiP0ABK7
PRIDEiP0ABK7

Expressioni

Inductioni

Under control of the CsgD transcription factor, part of the csgBAC/ymdA operon.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-15647688,EBI-15647688

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4259358, 11 interactors
DIPiDIP-46504N
IntActiP0ABK7, 1 interactor
STRINGi316385.ECDH10B_1113

Structurei

3D structure databases

ProteinModelPortaliP0ABK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CsgA/CsgB family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108U0V Bacteria
ENOG4111G8B LUCA
HOGENOMiHOG000118940
InParanoidiP0ABK7
KOiK04335
OMAiAIRVTQH
PhylomeDBiP0ABK7

Family and domain databases

InterProiView protein in InterPro
IPR009742 Curlin_rpt
PfamiView protein in Pfam
PF07012 Curlin_rpt, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ABK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKLLFMML TILGAPGIAA AAGYDLANSE YNFAVNELSK SSFNQAAIIG
60 70 80 90 100
QAGTNNSAQL RQGGSKLLAV VAQEGSSNRA KIDQTGDYNL AYIDQAGSAN
110 120 130 140 150
DASISQGAYG NTAMIIQKGS GNKANITQYG TQKTAIVVQR QSQMAIRVTQ

R
Length:151
Mass (Da):15,882
Last modified:November 8, 2005 - v1
Checksum:iB18D266B964014B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90754 Genomic DNA Translation: CAA62281.1
U00096 Genomic DNA Translation: AAC74125.1
AP009048 Genomic DNA Translation: BAA35831.1
PIRiS70787
RefSeqiNP_415559.1, NC_000913.3
WP_000791650.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74125; AAC74125; b1041
BAA35831; BAA35831; BAA35831
GeneIDi947391
KEGGiecj:JW1024
eco:b1041
PATRICifig|1411691.4.peg.1228

Similar proteinsi

Entry informationi

Entry nameiCSGB_ECOLI
AccessioniPrimary (citable) accession number: P0ABK7
Secondary accession number(s): P39828
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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