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Protein

Cytochrome bo(3) ubiquinol oxidase subunit 4

Gene

cyoD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochrome bo3 ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.3 Publications

GO - Molecular functioni

  • cytochrome bo3 ubiquinol oxidase activity Source: EcoCyc
  • cytochrome o ubiquinol oxidase activity Source: InterPro
  • electron transfer activity Source: EcoCyc
  • oxidoreduction-driven active transmembrane transporter activity Source: EcoCyc
  • proton transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • aerobic electron transport chain Source: EcoCyc
  • aerobic respiration Source: EcoCyc
  • electron transport coupled proton transport Source: EcoCyc

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CYOD-MONOMER
MetaCyc:CYOD-MONOMER

Protein family/group databases

TCDBi3.D.4.5.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome bo(3) ubiquinol oxidase subunit 4
Alternative name(s):
Cytochrome o ubiquinol oxidase subunit 4
Short name:
Cytochrome o subunit 4
Oxidase bo(3) subunit 4
Ubiquinol oxidase chain D
Ubiquinol oxidase polypeptide IV
Ubiquinol oxidase subunit 4
Gene namesi
Name:cyoD
Ordered Locus Names:b0429, JW0419
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Organism-specific databases

EcoGeneiEG10181 cyoD

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicCuratedAdd BLAST17
Transmembranei18 – 36HelicalCuratedAdd BLAST19
Topological domaini37 – 45PeriplasmicCurated9
Transmembranei46 – 64HelicalCuratedAdd BLAST19
Topological domaini65 – 80CytoplasmicCuratedAdd BLAST16
Transmembranei81 – 99HelicalCuratedAdd BLAST19
Topological domaini100 – 109PeriplasmicCurated10

GO - Cellular componenti

  • cytochrome o ubiquinol oxidase complex Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Increased reduction of the ubiquinone pool (in aerobically grown minimal medium with glucose).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839101 – 109Cytochrome bo(3) ubiquinol oxidase subunit 4Add BLAST109

Proteomic databases

PaxDbiP0ABJ6
PRIDEiP0ABJ6

Interactioni

Subunit structurei

Heterooctamer of two A chains, two B chains, two C chains and two D chains.2 Publications

Protein-protein interaction databases

BioGridi4260871, 223 interactors
DIPiDIP-48238N
IntActiP0ABJ6, 1 interactor
STRINGi316385.ECDH10B_0385

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FFTX-ray3.50
ProteinModelPortaliP0ABJ6
SMRiP0ABJ6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ABJ6

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41090KH Bacteria
COG3125 LUCA
HOGENOMiHOG000087516
InParanoidiP0ABJ6
KOiK02300
OMAiIVVHMVF
PhylomeDBiP0ABJ6

Family and domain databases

InterProiView protein in InterPro
IPR005171 Cyt_c_oxidase_su4_prok
IPR014210 Cyt_o_ubiqinol_oxidase_su4
PfamiView protein in Pfam
PF03626 COX4_pro, 1 hit
TIGRFAMsiTIGR02847 CyoD, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHSTDHSGA SHGSVKTYMT GFILSIILTV IPFWMVMTGA ASPAVILGTI
60 70 80 90 100
LAMAVVQVLV HLVCFLHMNT KSDEGWNMTA FVFTVLIIAI LVVGSIWIMW

NLNYNMMMH
Length:109
Mass (Da):12,029
Last modified:October 25, 2005 - v1
Checksum:iE2DBE23C893724BA
GO

Sequence cautioni

The sequence AAB40185 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05492 Genomic DNA Translation: AAA23634.1
U82664 Genomic DNA Translation: AAB40185.1 Different initiation.
U00096 Genomic DNA Translation: AAC73532.1
AP009048 Genomic DNA Translation: BAE76209.1
PIRiD42226
RefSeqiNP_414963.1, NC_000913.3
WP_000019869.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73532; AAC73532; b0429
BAE76209; BAE76209; BAE76209
GeneIDi944918
KEGGiecj:JW0419
eco:b0429
PATRICifig|1411691.4.peg.1848

Entry informationi

Entry nameiCYOD_ECOLI
AccessioniPrimary (citable) accession number: P0ABJ6
Secondary accession number(s): P18403, P77116, Q2MBZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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