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Protein

Cytochrome bo(3) ubiquinol oxidase subunit 4

Gene

cyoD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochrome bo3 ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.3 Publications

GO - Molecular functioni

  • cytochrome bo3 ubiquinol oxidase activity Source: EcoCyc
  • cytochrome o ubiquinol oxidase activity Source: InterPro
  • electron carrier activity Source: EcoCyc
  • hydrogen ion transmembrane transporter activity Source: EcoCyc
  • oxidoreduction-driven active transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • aerobic electron transport chain Source: EcoCyc
  • aerobic respiration Source: EcoCyc
  • electron transport coupled proton transport Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CYOD-MONOMER.
ECOL316407:JW0419-MONOMER.
MetaCyc:CYOD-MONOMER.

Protein family/group databases

TCDBi3.D.4.5.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome bo(3) ubiquinol oxidase subunit 4
Alternative name(s):
Cytochrome o ubiquinol oxidase subunit 4
Short name:
Cytochrome o subunit 4
Oxidase bo(3) subunit 4
Ubiquinol oxidase chain D
Ubiquinol oxidase polypeptide IV
Ubiquinol oxidase subunit 4
Gene namesi
Name:cyoD
Ordered Locus Names:b0429, JW0419
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10181. cyoD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicCuratedAdd BLAST17
Transmembranei18 – 36HelicalCuratedAdd BLAST19
Topological domaini37 – 45PeriplasmicCurated9
Transmembranei46 – 64HelicalCuratedAdd BLAST19
Topological domaini65 – 80CytoplasmicCuratedAdd BLAST16
Transmembranei81 – 99HelicalCuratedAdd BLAST19
Topological domaini100 – 109PeriplasmicCurated10

GO - Cellular componenti

  • cytochrome o ubiquinol oxidase complex Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Increased reduction of the ubiquinone pool (in aerobically grown minimal medium with glucose).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839101 – 109Cytochrome bo(3) ubiquinol oxidase subunit 4Add BLAST109

Proteomic databases

PaxDbiP0ABJ6.
PRIDEiP0ABJ6.

Interactioni

Subunit structurei

Heterooctamer of two A chains, two B chains, two C chains and two D chains.2 Publications

Protein-protein interaction databases

BioGridi4260871. 202 interactors.
DIPiDIP-48238N.
IntActiP0ABJ6. 1 interactor.
STRINGi511145.b0429.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FFTX-ray3.50
ProteinModelPortaliP0ABJ6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ABJ6.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41090KH. Bacteria.
COG3125. LUCA.
HOGENOMiHOG000087516.
InParanoidiP0ABJ6.
KOiK02300.
OMAiIVVHMVF.
PhylomeDBiP0ABJ6.

Family and domain databases

InterProiIPR005171. Cyt_c_oxidase_su4_prok.
IPR014210. Cyt_o_ubiqinol_oxidase_su4.
[Graphical view]
PfamiPF03626. COX4_pro. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02847. CyoD. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHSTDHSGA SHGSVKTYMT GFILSIILTV IPFWMVMTGA ASPAVILGTI
60 70 80 90 100
LAMAVVQVLV HLVCFLHMNT KSDEGWNMTA FVFTVLIIAI LVVGSIWIMW

NLNYNMMMH
Length:109
Mass (Da):12,029
Last modified:October 25, 2005 - v1
Checksum:iE2DBE23C893724BA
GO

Sequence cautioni

The sequence AAB40185 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05492 Genomic DNA. Translation: AAA23634.1.
U82664 Genomic DNA. Translation: AAB40185.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73532.1.
AP009048 Genomic DNA. Translation: BAE76209.1.
PIRiD42226.
RefSeqiNP_414963.1. NC_000913.3.
WP_000019869.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73532; AAC73532; b0429.
BAE76209; BAE76209; BAE76209.
GeneIDi944918.
KEGGiecj:JW0419.
eco:b0429.
PATRICi32116009. VBIEscCol129921_0446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05492 Genomic DNA. Translation: AAA23634.1.
U82664 Genomic DNA. Translation: AAB40185.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73532.1.
AP009048 Genomic DNA. Translation: BAE76209.1.
PIRiD42226.
RefSeqiNP_414963.1. NC_000913.3.
WP_000019869.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FFTX-ray3.50
ProteinModelPortaliP0ABJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260871. 202 interactors.
DIPiDIP-48238N.
IntActiP0ABJ6. 1 interactor.
STRINGi511145.b0429.

Protein family/group databases

TCDBi3.D.4.5.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

PaxDbiP0ABJ6.
PRIDEiP0ABJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73532; AAC73532; b0429.
BAE76209; BAE76209; BAE76209.
GeneIDi944918.
KEGGiecj:JW0419.
eco:b0429.
PATRICi32116009. VBIEscCol129921_0446.

Organism-specific databases

EchoBASEiEB0178.
EcoGeneiEG10181. cyoD.

Phylogenomic databases

eggNOGiENOG41090KH. Bacteria.
COG3125. LUCA.
HOGENOMiHOG000087516.
InParanoidiP0ABJ6.
KOiK02300.
OMAiIVVHMVF.
PhylomeDBiP0ABJ6.

Enzyme and pathway databases

BioCyciEcoCyc:CYOD-MONOMER.
ECOL316407:JW0419-MONOMER.
MetaCyc:CYOD-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0ABJ6.
PROiP0ABJ6.

Family and domain databases

InterProiIPR005171. Cyt_c_oxidase_su4_prok.
IPR014210. Cyt_o_ubiqinol_oxidase_su4.
[Graphical view]
PfamiPF03626. COX4_pro. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02847. CyoD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCYOD_ECOLI
AccessioniPrimary (citable) accession number: P0ABJ6
Secondary accession number(s): P18403, P77116, Q2MBZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.