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Protein

Cytochrome bo(3) ubiquinol oxidase subunit 3

Gene

cyoC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochrome bo3 ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.3 Publications

GO - Molecular functioni

  • cytochrome bo3 ubiquinol oxidase activity Source: EcoCyc
  • cytochrome-c oxidase activity Source: InterPro
  • cytochrome o ubiquinol oxidase activity Source: InterPro
  • electron carrier activity Source: EcoCyc
  • hydrogen ion transmembrane transporter activity Source: EcoCyc
  • oxidoreduction-driven active transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • aerobic electron transport chain Source: EcoCyc
  • aerobic respiration Source: EcoCyc
  • electron transport coupled proton transport Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CYOC-MONOMER.
ECOL316407:JW0420-MONOMER.
MetaCyc:CYOC-MONOMER.

Protein family/group databases

TCDBi3.D.4.5.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome bo(3) ubiquinol oxidase subunit 3
Alternative name(s):
Cytochrome o ubiquinol oxidase subunit 3
Short name:
Cytochrome o subunit 3
Oxidase bo(3) subunit 3
Ubiquinol oxidase chain C
Ubiquinol oxidase polypeptide III
Ubiquinol oxidase subunit 3
Gene namesi
Name:cyoC
Ordered Locus Names:b0430, JW0420
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10180. cyoC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31CytoplasmicCuratedAdd BLAST31
Transmembranei32 – 50HelicalCuratedAdd BLAST19
Topological domaini51 – 66PeriplasmicCuratedAdd BLAST16
Transmembranei67 – 85HelicalCuratedAdd BLAST19
Topological domaini86 – 101CytoplasmicCuratedAdd BLAST16
Transmembranei102 – 120HelicalCuratedAdd BLAST19
Topological domaini121 – 142PeriplasmicCuratedAdd BLAST22
Transmembranei143 – 161HelicalCuratedAdd BLAST19
Topological domaini162 – 184CytoplasmicCuratedAdd BLAST23
Transmembranei185 – 203HelicalCuratedAdd BLAST19
Topological domaini204PeriplasmicCurated1

GO - Cellular componenti

  • cytochrome o ubiquinol oxidase complex Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Increased reduction of the ubiquinone pool (in aerobically grown minimal medium with glucose).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001838931 – 204Cytochrome bo(3) ubiquinol oxidase subunit 3Add BLAST204

Proteomic databases

PaxDbiP0ABJ3.
PRIDEiP0ABJ3.

Interactioni

Subunit structurei

Heterooctamer of two A chains, two B chains, two C chains and two D chains.2 Publications

Protein-protein interaction databases

BioGridi4261578. 174 interactors.
DIPiDIP-47944N.
IntActiP0ABJ3. 1 interactor.
STRINGi511145.b0430.

Structurei

Secondary structure

1204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 30Combined sources6
Helixi33 – 36Combined sources4
Helixi39 – 47Combined sources9
Turni48 – 53Combined sources6
Helixi66 – 76Combined sources11
Helixi77 – 79Combined sources3
Turni80 – 84Combined sources5
Helixi86 – 88Combined sources3
Turni89 – 92Combined sources4
Helixi95 – 98Combined sources4
Helixi100 – 125Combined sources26
Turni135 – 137Combined sources3
Helixi138 – 146Combined sources9
Helixi149 – 152Combined sources4
Helixi155 – 166Combined sources12
Helixi176 – 194Combined sources19
Helixi195 – 202Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FFTX-ray3.50C/H25-204[»]
ProteinModelPortaliP0ABJ3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ABJ3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CCU. Bacteria.
COG1845. LUCA.
HOGENOMiHOG000086398.
InParanoidiP0ABJ3.
KOiK02299.
OMAiYTELVKH.
PhylomeDBiP0ABJ3.

Family and domain databases

CDDicd02863. Ubiquinol_oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase-like_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR014206. Cyt_c_ubiqinol_oxidase_su3.
IPR033946. Ubiquinol_oxase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
TIGRFAMsiTIGR02842. CyoC. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ABJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDTLTHAT AHAHEHGHHD AGGTKIFGFW IYLMSDCILF SILFATYAVL
60 70 80 90 100
VNGTAGGPTG KDIFELPFVL VETFLLLFSS ITYGMAAIAM YKNNKSQVIS
110 120 130 140 150
WLALTWLFGA GFIGMEIYEF HHLIVNGMGP DRSGFLSAFF ALVGTHGLHV
160 170 180 190 200
TSGLIWMAVL MVQIARRGLT STNRTRIMCL SLFWHFLDVV WICVFTVVYL

MGAM
Length:204
Mass (Da):22,623
Last modified:October 25, 2005 - v1
Checksum:iF1D6ABF9EB6CB5AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05492 Genomic DNA. Translation: AAA23633.1.
U82664 Genomic DNA. Translation: AAB40186.1.
U00096 Genomic DNA. Translation: AAC73533.1.
AP009048 Genomic DNA. Translation: BAE76210.1.
PIRiC42226.
RefSeqiNP_414964.1. NC_000913.3.
WP_000179819.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73533; AAC73533; b0430.
BAE76210; BAE76210; BAE76210.
GeneIDi946897.
KEGGiecj:JW0420.
eco:b0430.
PATRICi32116011. VBIEscCol129921_0447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05492 Genomic DNA. Translation: AAA23633.1.
U82664 Genomic DNA. Translation: AAB40186.1.
U00096 Genomic DNA. Translation: AAC73533.1.
AP009048 Genomic DNA. Translation: BAE76210.1.
PIRiC42226.
RefSeqiNP_414964.1. NC_000913.3.
WP_000179819.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FFTX-ray3.50C/H25-204[»]
ProteinModelPortaliP0ABJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261578. 174 interactors.
DIPiDIP-47944N.
IntActiP0ABJ3. 1 interactor.
STRINGi511145.b0430.

Protein family/group databases

TCDBi3.D.4.5.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

PaxDbiP0ABJ3.
PRIDEiP0ABJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73533; AAC73533; b0430.
BAE76210; BAE76210; BAE76210.
GeneIDi946897.
KEGGiecj:JW0420.
eco:b0430.
PATRICi32116011. VBIEscCol129921_0447.

Organism-specific databases

EchoBASEiEB0177.
EcoGeneiEG10180. cyoC.

Phylogenomic databases

eggNOGiENOG4105CCU. Bacteria.
COG1845. LUCA.
HOGENOMiHOG000086398.
InParanoidiP0ABJ3.
KOiK02299.
OMAiYTELVKH.
PhylomeDBiP0ABJ3.

Enzyme and pathway databases

BioCyciEcoCyc:CYOC-MONOMER.
ECOL316407:JW0420-MONOMER.
MetaCyc:CYOC-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0ABJ3.
PROiP0ABJ3.

Family and domain databases

CDDicd02863. Ubiquinol_oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase-like_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR014206. Cyt_c_ubiqinol_oxidase_su3.
IPR033946. Ubiquinol_oxase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
TIGRFAMsiTIGR02842. CyoC. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYOC_ECOLI
AccessioniPrimary (citable) accession number: P0ABJ3
Secondary accession number(s): P18402, Q2MBZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: November 30, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.