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Protein

ATP-dependent Clp protease ATP-binding subunit ClpA

Gene

clpA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent specificity component of the ClpAP protease. It directs the protease to specific substrates. It has unfoldase activity. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi214 – 221ATPSequence analysis8
Nucleotide bindingi495 – 502ATPSequence analysis8

GO - Molecular functioni

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpA
Gene namesi
Name:clpA
Ordered Locus Names:Z1119, ECs0968
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910801 – 758ATP-dependent Clp protease ATP-binding subunit ClpAAdd BLAST758

Interactioni

Subunit structurei

Component of the ClpAP complex composed of six ClpA subunits assembled into a hexameric ring in the presence of ATP, and fourteen ClpP subunits arranged in two heptameric rings. Binds to ClpS (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-247409.
STRINGi155864.Z1119.

Structurei

3D structure databases

ProteinModelPortaliP0ABI1.
SMRiP0ABI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni169 – 417IAdd BLAST249
Regioni421 – 609IIAdd BLAST189

Sequence similaritiesi

Belongs to the ClpA/ClpB family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105C2Z. Bacteria.
COG0542. LUCA.
HOGENOMiHOG000218210.
KOiK03694.

Family and domain databases

Gene3Di1.10.1780.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR013461. ClpA.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PRINTSiPR00300. CLPPROTEASEA.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF81923. SSF81923. 1 hit.
TIGRFAMsiTIGR02639. ClpA. 1 hit.
PROSITEiView protein in PROSITE
PS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNQELELSL NMAFARAREH RHEFMTVEHL LLALLSNPSA REALEACSVD
60 70 80 90 100
LVALRQELEA FIEQTTPVLP ASEEERDTQP TLSFQRVLQR AVFHVQSSGR
110 120 130 140 150
NEVTGANVLV AIFSEQESQA AYLLRKHEVS RLDVVNFISH GTRKDEPTQS
160 170 180 190 200
SDPGSQPNSE EQAGGEERME NFTTNLNQLA RVGGIDPLIG REKELERAIQ
210 220 230 240 250
VLCRRRKNNP LLVGESGVGK TAIAEGLAWR IVQGDVPEVM ADCTIYSLDI
260 270 280 290 300
GSLLAGTKYR GDFEKRFKAL LKQLEQDTNS ILFIDEIHTI IGAGAASGGQ
310 320 330 340 350
VDAANLIKPL LSSGKIRVIG STTYQEFSNI FEKDRALARR FQKIDITEPS
360 370 380 390 400
IEETVQIING LKPKYEAHHD VRYTAKAVRA AVELAVKYIN DRHLPDKAID
410 420 430 440 450
VIDEAGARAR LMPVSKRKKT VNVADIESVV ARIARIPEKS VSQSDRDTLK
460 470 480 490 500
NLGDRLKMLV FGQDKAIEAL TEAIKMARAG LGHEHKPVGS FLFAGPTGVG
510 520 530 540 550
KTEVTVQLSK ALGIELLRFD MSEYMERHTV SRLIGAPPGY VGFDQGGLLT
560 570 580 590 600
DAVIKHPHAV LLLDEIEKAH PDVFNILLQV MDNGTLTDNN GRKADFRNVV
610 620 630 640 650
LVMTTNAGVR ETERKSIGLI HQDNSTDAME EIKKIFTPEF RNRLDNIIWF
660 670 680 690 700
DHLSTDVIHQ VVDKFIVELQ VQLDQKGVSL EVSQEARNWL AEKGYDRAMG
710 720 730 740 750
ARPMARVIQD NLKKPLANEL LFGSLVDGGQ VTVALDKEKN ELTYGFQSAQ

KHKAEAAH
Length:758
Mass (Da):84,207
Last modified:October 25, 2005 - v1
Checksum:i0C96A2EB64A9F7DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55264.1.
BA000007 Genomic DNA. Translation: BAB34391.1.
PIRiD85600.
H90749.
RefSeqiNP_308995.1. NC_002695.1.
WP_000934041.1. NZ_MWVM01000013.1.

Genome annotation databases

EnsemblBacteriaiAAG55264; AAG55264; Z1119.
BAB34391; BAB34391; BAB34391.
GeneIDi917711.
KEGGiece:Z1119.
ecs:ECs0968.
PATRICifig|386585.9.peg.1084.

Similar proteinsi

Entry informationi

Entry nameiCLPA_ECO57
AccessioniPrimary (citable) accession number: P0ABI1
Secondary accession number(s): P15716, P77686
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: July 5, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families