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Protein

Rod shape-determining protein MreD

Gene

mreD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.

GO - Biological processi

  • regulation of cell shape Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Cell shape

Enzyme and pathway databases

BioCyciEcoCyc:EG10610-MONOMER.
ECOL316407:JW3218-MONOMER.

Protein family/group databases

TCDBi9.B.157.1.3. the cell shape-determining mrebcd (mrebcd) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Rod shape-determining protein MreD
Gene namesi
Name:mreD
Ordered Locus Names:b3249, JW3218
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10610. mreD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9PeriplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Topological domaini52 – 55PeriplasmicSequence analysis4
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 105CytoplasmicSequence analysisAdd BLAST29
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 131PeriplasmicSequence analysis5
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 162CytoplasmicSequence analysis10

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000627701 – 162Rod shape-determining protein MreDAdd BLAST162

Proteomic databases

PaxDbiP0ABH4.
PRIDEiP0ABH4.

Interactioni

Protein-protein interaction databases

BioGridi4262449. 393 interactors.
DIPiDIP-10257N.
STRINGi511145.b3249.

Structurei

3D structure databases

ProteinModelPortaliP0ABH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MreD family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105VQ7. Bacteria.
COG2891. LUCA.
HOGENOMiHOG000266108.
InParanoidiP0ABH4.
KOiK03571.
OMAiRNYSVWQ.

Family and domain databases

InterProiIPR007227. Cell_shape_determining_MreD.
IPR026034. MreD_proteobac.
[Graphical view]
PfamiPF04093. MreD. 1 hit.
[Graphical view]
PIRSFiPIRSF018472. MreD_proteobac. 1 hit.
TIGRFAMsiTIGR03426. shape_MreD. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASYRSQGRW VIWLSFLIAL LLQIMPWPDN LIVFRPNWVL LILLYWILAL
60 70 80 90 100
PHRVNVGTGF VMGAILDLIS GSTLGVRVLA MSIIAYLVAL KYQLFRNLAL
110 120 130 140 150
WQQALVVMLL SLVVDIIVFW AEFLVINVSF RPEVFWSSVV NGVLWPWIFL
160
LMRKVRQQFA VQ
Length:162
Mass (Da):18,788
Last modified:October 25, 2005 - v1
Checksum:i4D9DEAE3F38F99C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31792 Genomic DNA. Translation: AAA24156.1.
U18997 Genomic DNA. Translation: AAA58052.1.
U00096 Genomic DNA. Translation: AAC76281.1.
AP009048 Genomic DNA. Translation: BAE77291.1.
X57166 Genomic DNA. Translation: CAA40455.1.
PIRiJV0060.
RefSeqiNP_417715.1. NC_000913.3.
WP_000179409.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76281; AAC76281; b3249.
BAE77291; BAE77291; BAE77291.
GeneIDi947756.
KEGGiecj:JW3218.
eco:b3249.
PATRICi32121924. VBIEscCol129921_3346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31792 Genomic DNA. Translation: AAA24156.1.
U18997 Genomic DNA. Translation: AAA58052.1.
U00096 Genomic DNA. Translation: AAC76281.1.
AP009048 Genomic DNA. Translation: BAE77291.1.
X57166 Genomic DNA. Translation: CAA40455.1.
PIRiJV0060.
RefSeqiNP_417715.1. NC_000913.3.
WP_000179409.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ABH4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262449. 393 interactors.
DIPiDIP-10257N.
STRINGi511145.b3249.

Protein family/group databases

TCDBi9.B.157.1.3. the cell shape-determining mrebcd (mrebcd) family.

Proteomic databases

PaxDbiP0ABH4.
PRIDEiP0ABH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76281; AAC76281; b3249.
BAE77291; BAE77291; BAE77291.
GeneIDi947756.
KEGGiecj:JW3218.
eco:b3249.
PATRICi32121924. VBIEscCol129921_3346.

Organism-specific databases

EchoBASEiEB0605.
EcoGeneiEG10610. mreD.

Phylogenomic databases

eggNOGiENOG4105VQ7. Bacteria.
COG2891. LUCA.
HOGENOMiHOG000266108.
InParanoidiP0ABH4.
KOiK03571.
OMAiRNYSVWQ.

Enzyme and pathway databases

BioCyciEcoCyc:EG10610-MONOMER.
ECOL316407:JW3218-MONOMER.

Miscellaneous databases

PROiP0ABH4.

Family and domain databases

InterProiIPR007227. Cell_shape_determining_MreD.
IPR026034. MreD_proteobac.
[Graphical view]
PfamiPF04093. MreD. 1 hit.
[Graphical view]
PIRSFiPIRSF018472. MreD_proteobac. 1 hit.
TIGRFAMsiTIGR03426. shape_MreD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMRED_ECOLI
AccessioniPrimary (citable) accession number: P0ABH4
Secondary accession number(s): P16927, Q2M8W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.