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Protein

Rod shape-determining protein MreD

Gene

mreD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.

GO - Biological processi

  • regulation of cell shape Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Cell shape

Enzyme and pathway databases

BioCyciEcoCyc:EG10610-MONOMER.
ECOL316407:JW3218-MONOMER.

Protein family/group databases

TCDBi9.B.157.1.3. the cell shape-determining mrebcd (mrebcd) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Rod shape-determining protein MreD
Gene namesi
Name:mreD
Ordered Locus Names:b3249, JW3218
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10610. mreD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99PeriplasmicSequence analysis
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Transmembranei31 – 5121HelicalSequence analysisAdd
BLAST
Topological domaini52 – 554PeriplasmicSequence analysis
Transmembranei56 – 7621HelicalSequence analysisAdd
BLAST
Topological domaini77 – 10529CytoplasmicSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Topological domaini127 – 1315PeriplasmicSequence analysis
Transmembranei132 – 15221HelicalSequence analysisAdd
BLAST
Topological domaini153 – 16210CytoplasmicSequence analysis

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Rod shape-determining protein MreDPRO_0000062770Add
BLAST

Proteomic databases

PaxDbiP0ABH4.

Interactioni

Protein-protein interaction databases

BioGridi4262449. 393 interactions.
DIPiDIP-10257N.
STRINGi511145.b3249.

Structurei

3D structure databases

ProteinModelPortaliP0ABH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MreD family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105VQ7. Bacteria.
COG2891. LUCA.
HOGENOMiHOG000266108.
InParanoidiP0ABH4.
KOiK03571.
OMAiRNYSVWQ.
OrthoDBiEOG63JR9Q.

Family and domain databases

InterProiIPR007227. Cell_shape_determining_MreD.
IPR026034. MreD_proteobac.
[Graphical view]
PfamiPF04093. MreD. 1 hit.
[Graphical view]
PIRSFiPIRSF018472. MreD_proteobac. 1 hit.
TIGRFAMsiTIGR03426. shape_MreD. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASYRSQGRW VIWLSFLIAL LLQIMPWPDN LIVFRPNWVL LILLYWILAL
60 70 80 90 100
PHRVNVGTGF VMGAILDLIS GSTLGVRVLA MSIIAYLVAL KYQLFRNLAL
110 120 130 140 150
WQQALVVMLL SLVVDIIVFW AEFLVINVSF RPEVFWSSVV NGVLWPWIFL
160
LMRKVRQQFA VQ
Length:162
Mass (Da):18,788
Last modified:October 25, 2005 - v1
Checksum:i4D9DEAE3F38F99C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31792 Genomic DNA. Translation: AAA24156.1.
U18997 Genomic DNA. Translation: AAA58052.1.
U00096 Genomic DNA. Translation: AAC76281.1.
AP009048 Genomic DNA. Translation: BAE77291.1.
X57166 Genomic DNA. Translation: CAA40455.1.
PIRiJV0060.
RefSeqiNP_417715.1. NC_000913.3.
WP_000179409.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76281; AAC76281; b3249.
BAE77291; BAE77291; BAE77291.
GeneIDi947756.
KEGGiecj:JW3218.
eco:b3249.
PATRICi32121924. VBIEscCol129921_3346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31792 Genomic DNA. Translation: AAA24156.1.
U18997 Genomic DNA. Translation: AAA58052.1.
U00096 Genomic DNA. Translation: AAC76281.1.
AP009048 Genomic DNA. Translation: BAE77291.1.
X57166 Genomic DNA. Translation: CAA40455.1.
PIRiJV0060.
RefSeqiNP_417715.1. NC_000913.3.
WP_000179409.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ABH4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262449. 393 interactions.
DIPiDIP-10257N.
STRINGi511145.b3249.

Protein family/group databases

TCDBi9.B.157.1.3. the cell shape-determining mrebcd (mrebcd) family.

Proteomic databases

PaxDbiP0ABH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76281; AAC76281; b3249.
BAE77291; BAE77291; BAE77291.
GeneIDi947756.
KEGGiecj:JW3218.
eco:b3249.
PATRICi32121924. VBIEscCol129921_3346.

Organism-specific databases

EchoBASEiEB0605.
EcoGeneiEG10610. mreD.

Phylogenomic databases

eggNOGiENOG4105VQ7. Bacteria.
COG2891. LUCA.
HOGENOMiHOG000266108.
InParanoidiP0ABH4.
KOiK03571.
OMAiRNYSVWQ.
OrthoDBiEOG63JR9Q.

Enzyme and pathway databases

BioCyciEcoCyc:EG10610-MONOMER.
ECOL316407:JW3218-MONOMER.

Miscellaneous databases

PROiP0ABH4.

Family and domain databases

InterProiIPR007227. Cell_shape_determining_MreD.
IPR026034. MreD_proteobac.
[Graphical view]
PfamiPF04093. MreD. 1 hit.
[Graphical view]
PIRSFiPIRSF018472. MreD_proteobac. 1 hit.
TIGRFAMsiTIGR03426. shape_MreD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "New mre genes mreC and mreD, responsible for formation of the rod shape of Escherichia coli cells."
    Wachi M., Doi M., Okada Y., Matsuhashi M.
    J. Bacteriol. 171:6511-6516(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Sequence of the downstream flanking region of the shape-determining genes mreBCD of Escherichia coli."
    Wachi M., Doi M., Ueda T., Ueki M., Tsuritani K., Nagai K., Matsuhashi M.
    Gene 106:135-136(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 153-162.
    Strain: K12.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiMRED_ECOLI
AccessioniPrimary (citable) accession number: P0ABH4
Secondary accession number(s): P16927, Q2M8W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: January 20, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.