P0ABH0 (FTSA_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell division protein FtsA

Gene names

Name:	ftsA
Synonyms:	divA
Ordered Locus Names:	b0094, JW0092

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein may be involved in anomalous filament growth By similarity. May be a component of the septum.
Subunit structure	Interacts with FtsZ By similarity.
Sequence similarities	Belongs to the FtsA/MreB family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis Inferred from mutant phenotype PubMed 8917533. Source: EcoliWiki regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell division site part Inferred from direct assay PubMed 8917533. Source: EcoliWiki internal side of plasma membrane Inferred from direct assay PubMed 2203741. Source: EcoCyc
Molecular_function	ATP binding Inferred from direct assay PubMed 19297332. Source: EcoCyc identical protein binding Inferred from mutant phenotype PubMed 17986188. Source: EcoCyc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		4	EBI-550562,EBI-550562
ftsN	P29131	7	EBI-550562,EBI-1134233
ftsZ	P0A9A6	6	EBI-550562,EBI-370963

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 420	420	Cell division protein FtsA		PRO_0000062734
Experimental info
	Sequence conflict	339	1	A → R Ref.1
	Sequence conflict	339	1	A → R Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P0ABH0 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: C2475377A229B982	FASTA	420	45,330
	10 20 30 40 50 60 MIKATDRKLV VGLEIGTAKV AALVGEVLPD GMVNIIGVGS CPSRGMDKGG VNDLESVVKC 70 80 90 100 110 120 VQRAIDQAEL MADCQISSVY LALSGKHISC QNEIGMVPIS EEEVTQEDVE NVVHTAKSVR 130 140 150 160 170 180 VRDEHRVLHV IPQEYAIDYQ EGIKNPVGLS GVRMQAKVHL ITCHNDMAKN IVKAVERCGL 190 200 210 220 230 240 KVDQLIFAGL ASSYSVLTED ERELGVCVVD IGGGTMDIAV YTGGALRHTK VIPYAGNVVT 250 260 270 280 290 300 SDIAYAFGTP PSDAEAIKVR HGCALGSIVG KDESVEVPSV GGRPPRSLQR QTLAEVIEPR 310 320 330 340 350 360 YTELLNLVNE EILQLQEKLR QQGVKHHLAA GIVLTGGAAQ IEGLAACAQR VFHTQVRIGA 370 380 390 400 410 420 PLNITGLTDY AQEPYYSTAV GLLHYGKESH LNGEAEVEKR VTASVGSWIK RLNSWLRKEF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and transcriptional organization of essential cell division genes ftsQ and ftsA of Escherichia coli: evidence for overlapping transcriptional units." Robinson A.C., Kenan D.J., Hatfull G.F., Sullivan N.F., Spiegelberg R., Donachie W.D. J. Bacteriol. 160:546-555(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"Structure and expression of the cell division genes ftsQ, ftsA and ftsZ." Yi Q.-M., Rockenbach S., Ward J.E. Jr., Lutkenhaus J. J. Mol. Biol. 184:399-412(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[3]	"Mapping and characterization of mutants of the Escherichia coli cell division gene, ftsA." Robinson A.C., Begg K.J., Sweeney J., Condie A., Donachie W.D. Mol. Microbiol. 2:581-588(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTANTS TEMPERATURE-SENSITIVE.
[4]	"Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region." Yura T., Mori H., Nagai H., Nagata T., Ishihama A., Fujita N., Isono K., Mizobuchi K., Nakata A. Nucleic Acids Res. 20:3305-3308(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12.
[5]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[6]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[7]	"Regulation of expression of the ftsA cell division gene by sequences in upstream genes." Dewar S.J., Donachie W.D. J. Bacteriol. 172:6611-6614(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-116.
[8]	"The nucleotide sequence of the essential cell-division gene ftsZ of Escherichia coli." Yi Q.-M., Lutkenhaus J. Gene 36:241-247(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 318-420. Strain: K12.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	K02668 Genomic DNA. Translation: AAA23817.1. M36531 Genomic DNA. Translation: AAA23811.1. X55034 Genomic DNA. Translation: CAA38871.1. U00096 Genomic DNA. Translation: AAC73205.1. AP009048 Genomic DNA. Translation: BAB96662.1.
PIR	CEECA. B23318.
RefSeq	NP_414636.1. NC_000913.2. YP_488399.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P0ABH0.
SMR	P0ABH0. Positions 13-381.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-47983N.
IntAct	P0ABH0. 26 interactions.
STRING	511145.b0094.
Proteomic databases
PaxDb	P0ABH0.
PRIDE	P0ABH0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC73205; AAC73205; b0094. BAB96662; BAB96662; BAB96662.
GeneID	12932892. 944778.
KEGG	ecj:Y75_p0093. eco:b0094.
PATRIC	32115293. VBIEscCol129921_0098.
Organism-specific databases
EchoBASE	EB0335.
EcoGene	EG10339. ftsA.
Phylogenomic databases
eggNOG	COG0849.
HOGENOM	HOG000049205.
KO	K03590.
OMA	IIHVLPQ.
ProtClustDB	PRK09472.
Enzyme and pathway databases
BioCyc	EcoCyc:EG10339-MONOMER. ECOL316407:JW0092-MONOMER.
Gene expression databases
Genevestigator	P0ABH0.
Family and domain databases
InterPro	IPR020823. Cell_div_FtsA. IPR003494. SHS2_FtsA. [Graphical view]
Pfam	PF02491. SHS2_FTSA. 1 hit. [Graphical view]
PIRSF	PIRSF003101. FtsA. 1 hit.
SMART	SM00842. FtsA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01174. ftsA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FTSA_ECOLI

Accession

Primary (citable) accession number: P0ABH0
Secondary accession number(s): P06137, Q47229

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program