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P0ABH0

- FTSA_ECOLI

UniProt

P0ABH0 - FTSA_ECOLI

Protein

Cell division protein FtsA

Gene

ftsA

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Jan 1988)
      Previous versions | rss
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    Functioni

    This protein may be involved in anomalous filament growth By similarity. May be a component of the septum.By similarity

    GO - Molecular functioni

    1. ATP binding Source: EcoCyc
    2. identical protein binding Source: IntAct
    3. protein binding Source: IntAct

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: EcoliWiki
    3. regulation of cell shape Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape

    Enzyme and pathway databases

    BioCyciEcoCyc:EG10339-MONOMER.
    ECOL316407:JW0092-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division protein FtsA
    Gene namesi
    Name:ftsA
    Synonyms:divA
    Ordered Locus Names:b0094, JW0092
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG10339. ftsA.

    Subcellular locationi

    GO - Cellular componenti

    1. cell division site Source: EcoliWiki
    2. cytoplasmic side of plasma membrane Source: EcoCyc

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 420420Cell division protein FtsAPRO_0000062734Add
    BLAST

    Proteomic databases

    PaxDbiP0ABH0.
    PRIDEiP0ABH0.

    Expressioni

    Gene expression databases

    GenevestigatoriP0ABH0.

    Interactioni

    Subunit structurei

    Interacts with FtsZ.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself4EBI-550562,EBI-550562
    ftsNP291317EBI-550562,EBI-1134233
    ftsZP0A9A66EBI-550562,EBI-370963

    Protein-protein interaction databases

    DIPiDIP-47983N.
    IntActiP0ABH0. 26 interactions.
    STRINGi511145.b0094.

    Structurei

    3D structure databases

    ProteinModelPortaliP0ABH0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FtsA/MreB family.Curated

    Phylogenomic databases

    eggNOGiCOG0849.
    HOGENOMiHOG000049205.
    KOiK03590.
    OMAiIEDPLGM.
    OrthoDBiEOG6TR0B6.
    PhylomeDBiP0ABH0.

    Family and domain databases

    InterProiIPR020823. Cell_div_FtsA.
    IPR003494. SHS2_FtsA.
    [Graphical view]
    PfamiPF02491. SHS2_FTSA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003101. FtsA. 1 hit.
    SMARTiSM00842. FtsA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01174. ftsA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0ABH0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKATDRKLV VGLEIGTAKV AALVGEVLPD GMVNIIGVGS CPSRGMDKGG    50
    VNDLESVVKC VQRAIDQAEL MADCQISSVY LALSGKHISC QNEIGMVPIS 100
    EEEVTQEDVE NVVHTAKSVR VRDEHRVLHV IPQEYAIDYQ EGIKNPVGLS 150
    GVRMQAKVHL ITCHNDMAKN IVKAVERCGL KVDQLIFAGL ASSYSVLTED 200
    ERELGVCVVD IGGGTMDIAV YTGGALRHTK VIPYAGNVVT SDIAYAFGTP 250
    PSDAEAIKVR HGCALGSIVG KDESVEVPSV GGRPPRSLQR QTLAEVIEPR 300
    YTELLNLVNE EILQLQEKLR QQGVKHHLAA GIVLTGGAAQ IEGLAACAQR 350
    VFHTQVRIGA PLNITGLTDY AQEPYYSTAV GLLHYGKESH LNGEAEVEKR 400
    VTASVGSWIK RLNSWLRKEF 420
    Length:420
    Mass (Da):45,330
    Last modified:January 1, 1988 - v1
    Checksum:iC2475377A229B982
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti339 – 3391A → R(PubMed:6094474)Curated
    Sequence conflicti339 – 3391A → R(PubMed:2846985)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02668 Genomic DNA. Translation: AAA23817.1.
    M36531 Genomic DNA. Translation: AAA23811.1.
    X55034 Genomic DNA. Translation: CAA38871.1.
    U00096 Genomic DNA. Translation: AAC73205.1.
    AP009048 Genomic DNA. Translation: BAB96662.1.
    PIRiB23318. CEECA.
    RefSeqiNP_414636.1. NC_000913.3.
    YP_488399.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC73205; AAC73205; b0094.
    BAB96662; BAB96662; BAB96662.
    GeneIDi12932892.
    944778.
    KEGGiecj:Y75_p0093.
    eco:b0094.
    PATRICi32115293. VBIEscCol129921_0098.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02668 Genomic DNA. Translation: AAA23817.1 .
    M36531 Genomic DNA. Translation: AAA23811.1 .
    X55034 Genomic DNA. Translation: CAA38871.1 .
    U00096 Genomic DNA. Translation: AAC73205.1 .
    AP009048 Genomic DNA. Translation: BAB96662.1 .
    PIRi B23318. CEECA.
    RefSeqi NP_414636.1. NC_000913.3.
    YP_488399.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P0ABH0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-47983N.
    IntActi P0ABH0. 26 interactions.
    STRINGi 511145.b0094.

    Proteomic databases

    PaxDbi P0ABH0.
    PRIDEi P0ABH0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC73205 ; AAC73205 ; b0094 .
    BAB96662 ; BAB96662 ; BAB96662 .
    GeneIDi 12932892.
    944778.
    KEGGi ecj:Y75_p0093.
    eco:b0094.
    PATRICi 32115293. VBIEscCol129921_0098.

    Organism-specific databases

    EchoBASEi EB0335.
    EcoGenei EG10339. ftsA.

    Phylogenomic databases

    eggNOGi COG0849.
    HOGENOMi HOG000049205.
    KOi K03590.
    OMAi IEDPLGM.
    OrthoDBi EOG6TR0B6.
    PhylomeDBi P0ABH0.

    Enzyme and pathway databases

    BioCyci EcoCyc:EG10339-MONOMER.
    ECOL316407:JW0092-MONOMER.

    Miscellaneous databases

    PROi P0ABH0.

    Gene expression databases

    Genevestigatori P0ABH0.

    Family and domain databases

    InterProi IPR020823. Cell_div_FtsA.
    IPR003494. SHS2_FtsA.
    [Graphical view ]
    Pfami PF02491. SHS2_FTSA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003101. FtsA. 1 hit.
    SMARTi SM00842. FtsA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01174. ftsA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and transcriptional organization of essential cell division genes ftsQ and ftsA of Escherichia coli: evidence for overlapping transcriptional units."
      Robinson A.C., Kenan D.J., Hatfull G.F., Sullivan N.F., Spiegelberg R., Donachie W.D.
      J. Bacteriol. 160:546-555(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12.
    2. "Structure and expression of the cell division genes ftsQ, ftsA and ftsZ."
      Yi Q.-M., Rockenbach S., Ward J.E. Jr., Lutkenhaus J.
      J. Mol. Biol. 184:399-412(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12.
    3. "Mapping and characterization of mutants of the Escherichia coli cell division gene, ftsA."
      Robinson A.C., Begg K.J., Sweeney J., Condie A., Donachie W.D.
      Mol. Microbiol. 2:581-588(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTANTS TEMPERATURE-SENSITIVE.
    4. "Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region."
      Yura T., Mori H., Nagai H., Nagata T., Ishihama A., Fujita N., Isono K., Mizobuchi K., Nakata A.
      Nucleic Acids Res. 20:3305-3308(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    6. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    7. "Regulation of expression of the ftsA cell division gene by sequences in upstream genes."
      Dewar S.J., Donachie W.D.
      J. Bacteriol. 172:6611-6614(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-116.
    8. "The nucleotide sequence of the essential cell-division gene ftsZ of Escherichia coli."
      Yi Q.-M., Lutkenhaus J.
      Gene 36:241-247(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 318-420.
      Strain: K12.

    Entry informationi

    Entry nameiFTSA_ECOLI
    AccessioniPrimary (citable) accession number: P0ABH0
    Secondary accession number(s): P06137, Q47229
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3