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Protein

Cell division protein FtsA

Gene

ftsA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein may be involved in anomalous filament growth (By similarity). May be a component of the septum.By similarity

GO - Molecular functioni

  1. ATP binding Source: EcoCyc
  2. identical protein binding Source: IntAct

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: EcoliWiki
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Cell shape

Enzyme and pathway databases

BioCyciEcoCyc:EG10339-MONOMER.
ECOL316407:JW0092-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsA
Gene namesi
Name:ftsA
Synonyms:divA
Ordered Locus Names:b0094, JW0092
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG10339. ftsA.

Subcellular locationi

GO - Cellular componenti

  1. cell division site Source: EcoliWiki
  2. cytoplasmic side of plasma membrane Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Cell division protein FtsAPRO_0000062734Add
BLAST

Proteomic databases

PaxDbiP0ABH0.
PRIDEiP0ABH0.

Expressioni

Gene expression databases

GenevestigatoriP0ABH0.

Interactioni

Subunit structurei

Interacts with FtsZ.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-550562,EBI-550562
ftsNP291317EBI-550562,EBI-1134233
ftsZP0A9A66EBI-550562,EBI-370963

Protein-protein interaction databases

DIPiDIP-47983N.
IntActiP0ABH0. 26 interactions.
STRINGi511145.b0094.

Structurei

3D structure databases

ProteinModelPortaliP0ABH0.
SMRiP0ABH0. Positions 9-388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsA/MreB family.Curated

Phylogenomic databases

eggNOGiCOG0849.
HOGENOMiHOG000049205.
InParanoidiP0ABH0.
KOiK03590.
OMAiAGGHTNY.
OrthoDBiEOG6TR0B6.
PhylomeDBiP0ABH0.

Family and domain databases

InterProiIPR020823. Cell_div_FtsA.
IPR003494. SHS2_FtsA.
[Graphical view]
PfamiPF02491. SHS2_FTSA. 1 hit.
[Graphical view]
PIRSFiPIRSF003101. FtsA. 1 hit.
SMARTiSM00842. FtsA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01174. ftsA. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABH0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKATDRKLV VGLEIGTAKV AALVGEVLPD GMVNIIGVGS CPSRGMDKGG
60 70 80 90 100
VNDLESVVKC VQRAIDQAEL MADCQISSVY LALSGKHISC QNEIGMVPIS
110 120 130 140 150
EEEVTQEDVE NVVHTAKSVR VRDEHRVLHV IPQEYAIDYQ EGIKNPVGLS
160 170 180 190 200
GVRMQAKVHL ITCHNDMAKN IVKAVERCGL KVDQLIFAGL ASSYSVLTED
210 220 230 240 250
ERELGVCVVD IGGGTMDIAV YTGGALRHTK VIPYAGNVVT SDIAYAFGTP
260 270 280 290 300
PSDAEAIKVR HGCALGSIVG KDESVEVPSV GGRPPRSLQR QTLAEVIEPR
310 320 330 340 350
YTELLNLVNE EILQLQEKLR QQGVKHHLAA GIVLTGGAAQ IEGLAACAQR
360 370 380 390 400
VFHTQVRIGA PLNITGLTDY AQEPYYSTAV GLLHYGKESH LNGEAEVEKR
410 420
VTASVGSWIK RLNSWLRKEF
Length:420
Mass (Da):45,330
Last modified:January 1, 1988 - v1
Checksum:iC2475377A229B982
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti339 – 3391A → R(PubMed:6094474)Curated
Sequence conflicti339 – 3391A → R(PubMed:2846985)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02668 Genomic DNA. Translation: AAA23817.1.
M36531 Genomic DNA. Translation: AAA23811.1.
X55034 Genomic DNA. Translation: CAA38871.1.
U00096 Genomic DNA. Translation: AAC73205.1.
AP009048 Genomic DNA. Translation: BAB96662.1.
PIRiB23318. CEECA.
RefSeqiNP_414636.1. NC_000913.3.
YP_488399.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73205; AAC73205; b0094.
BAB96662; BAB96662; BAB96662.
GeneIDi12932892.
944778.
KEGGiecj:Y75_p0093.
eco:b0094.
PATRICi32115293. VBIEscCol129921_0098.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02668 Genomic DNA. Translation: AAA23817.1.
M36531 Genomic DNA. Translation: AAA23811.1.
X55034 Genomic DNA. Translation: CAA38871.1.
U00096 Genomic DNA. Translation: AAC73205.1.
AP009048 Genomic DNA. Translation: BAB96662.1.
PIRiB23318. CEECA.
RefSeqiNP_414636.1. NC_000913.3.
YP_488399.1. NC_007779.1.

3D structure databases

ProteinModelPortaliP0ABH0.
SMRiP0ABH0. Positions 9-388.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-47983N.
IntActiP0ABH0. 26 interactions.
STRINGi511145.b0094.

Proteomic databases

PaxDbiP0ABH0.
PRIDEiP0ABH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73205; AAC73205; b0094.
BAB96662; BAB96662; BAB96662.
GeneIDi12932892.
944778.
KEGGiecj:Y75_p0093.
eco:b0094.
PATRICi32115293. VBIEscCol129921_0098.

Organism-specific databases

EchoBASEiEB0335.
EcoGeneiEG10339. ftsA.

Phylogenomic databases

eggNOGiCOG0849.
HOGENOMiHOG000049205.
InParanoidiP0ABH0.
KOiK03590.
OMAiAGGHTNY.
OrthoDBiEOG6TR0B6.
PhylomeDBiP0ABH0.

Enzyme and pathway databases

BioCyciEcoCyc:EG10339-MONOMER.
ECOL316407:JW0092-MONOMER.

Miscellaneous databases

PROiP0ABH0.

Gene expression databases

GenevestigatoriP0ABH0.

Family and domain databases

InterProiIPR020823. Cell_div_FtsA.
IPR003494. SHS2_FtsA.
[Graphical view]
PfamiPF02491. SHS2_FTSA. 1 hit.
[Graphical view]
PIRSFiPIRSF003101. FtsA. 1 hit.
SMARTiSM00842. FtsA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01174. ftsA. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and transcriptional organization of essential cell division genes ftsQ and ftsA of Escherichia coli: evidence for overlapping transcriptional units."
    Robinson A.C., Kenan D.J., Hatfull G.F., Sullivan N.F., Spiegelberg R., Donachie W.D.
    J. Bacteriol. 160:546-555(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Structure and expression of the cell division genes ftsQ, ftsA and ftsZ."
    Yi Q.-M., Rockenbach S., Ward J.E. Jr., Lutkenhaus J.
    J. Mol. Biol. 184:399-412(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  3. "Mapping and characterization of mutants of the Escherichia coli cell division gene, ftsA."
    Robinson A.C., Begg K.J., Sweeney J., Condie A., Donachie W.D.
    Mol. Microbiol. 2:581-588(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTANTS TEMPERATURE-SENSITIVE.
  4. "Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region."
    Yura T., Mori H., Nagai H., Nagata T., Ishihama A., Fujita N., Isono K., Mizobuchi K., Nakata A.
    Nucleic Acids Res. 20:3305-3308(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  6. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  7. "Regulation of expression of the ftsA cell division gene by sequences in upstream genes."
    Dewar S.J., Donachie W.D.
    J. Bacteriol. 172:6611-6614(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-116.
  8. "The nucleotide sequence of the essential cell-division gene ftsZ of Escherichia coli."
    Yi Q.-M., Lutkenhaus J.
    Gene 36:241-247(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 318-420.
    Strain: K12.

Entry informationi

Entry nameiFTSA_ECOLI
AccessioniPrimary (citable) accession number: P0ABH0
Secondary accession number(s): P06137, Q47229
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: February 4, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.