P0ABG3 (CDSA_SHIFL) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 64.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Phosphatidate cytidylyltransferase EC=2.7.7.41 Alternative name(s): CDP-DAG synthase CDP-DG synthase CDP-diacylglycerol synthase Short name=CDS CDP-diglyceride pyrophosphorylase CDP-diglyceride synthase CTP:phosphatidate cytidylyltransferase | ||||
| Gene names |
| ||||
| Organism | Shigella flexneri [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 623 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella![]() |
Protein attributes
| Sequence length | 285 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | CTP + phosphatidate = diphosphate + CDP-diacylglycerol. |
| Pathway | |
| Subcellular location | Cell inner membrane; Multi-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the CDS family. |
| Sequence caution | The sequence AAN41827.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAP15708.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism |
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | Nucleotidyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | CDP-diacylglycerol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway |
| Cellular_component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 285 | 285 | Phosphatidate cytidylyltransferase | PRO_0000090746 | |||||
Regions | |||||||||
| Transmembrane | 10 – 30 | 21 | Helical; Potential | ||||||
| Transmembrane | 56 – 76 | 21 | Helical; Potential | ||||||
| Transmembrane | 93 – 113 | 21 | Helical; Potential | ||||||
| Transmembrane | 121 – 141 | 21 | Helical; Potential | ||||||
| Transmembrane | 151 – 171 | 21 | Helical; Potential | ||||||
| Transmembrane | 190 – 210 | 21 | Helical; Potential | ||||||
| Transmembrane | 213 – 233 | 21 | Helical; Potential | ||||||
| Transmembrane | 264 – 284 | 21 | Helical; Potential | ||||||
Sequences
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References
| [1] | "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157." Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. Yu J.Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 301 / Serotype 2a. |
| [2] | "Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T." Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R. Infect. Immun. 71:2775-2786(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700930 / 2457T / Serotype 2a. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE005674 Genomic DNA. Translation: AAN41827.2. Different initiation. AE014073 Genomic DNA. Translation: AAP15708.1. Different initiation. |
| RefSeq | NP_706120.4. NC_004337.2. NP_835903.2. NC_004741.1. |
3D structure databases | |
| ProteinModelPortal | P0ABG3. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 198214.SF0165. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | AAN41827; AAN41827; SF0165. AAP15708; AAP15708; S0168. |
| GeneID | 1024478. 1076599. |
| KEGG | sfl:SF0165. sfx:S0168. |
| PATRIC | 18701288. VBIShiFle31049_0185. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0575. |
| HOGENOM | HOG000006168. |
| KO | K00981. |
| OMA | WEWGRLN. |
| ProtClustDB | PRK11624. |
Enzyme and pathway databases | |
| UniPathway | UPA00557; UER00614. |
Family and domain databases | |
| InterPro | IPR000374. PC_trans. [Graphical view] |
| Pfam | PF01148. CTP_transf_1. 1 hit. [Graphical view] |
| PROSITE | PS01315. CDS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CDSA_SHIFL | ||||||||
| Accession | Primary (citable) accession number: P0ABG3 Secondary accession number(s): P06466 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
