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Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Ordered Locus Names:SF0165, S0168
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence AnalysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence AnalysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence AnalysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Phosphatidate cytidylyltransferasePRO_0000090746Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198214.SF0165.

Structurei

3D structure databases

ProteinModelPortaliP0ABG3.
SMRiP0ABG3. Positions 150-273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
HOGENOMiHOG000006168.
KOiK00981.
OrthoDBiEOG6TBHJT.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ABG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKYRLISAF VLIPVVIAAL FLLPPVGFAI VTLVVCMLAA WEWGQLSGFT
60 70 80 90 100
TRSQRVWLAV LCGLLLALML FLLPEYHRNI HQPLVEISLW ASLGWWIVAL
110 120 130 140 150
LLVLFYPGSA AIWRNSKTLR LIFGVLTIVP FFWGMLALRA WHYDENHYSG
160 170 180 190 200
AIWLLYVMIL VWGADSGAYM FGKLFGKHKL APKVSPGKTW QGFIGGLATA
210 220 230 240 250
AVISWGYGMW ANLDVAPVTL LICSIVAALA SVLGDLTESM FKREAGIKDS
260 270 280
GHLIPGHGGI LDRIDSLTAA VPVFACLLLL VFRTL
Length:285
Mass (Da):31,454
Last modified:November 13, 2007 - v2
Checksum:i0D77DCD5EC5FBA9F
GO

Sequence cautioni

The sequence AAN41827.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAP15708.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN41827.2. Different initiation.
AE014073 Genomic DNA. Translation: AAP15708.1. Different initiation.
RefSeqiNP_706120.4. NC_004337.2.
NP_835903.2. NC_004741.1.

Genome annotation databases

EnsemblBacteriaiAAN41827; AAN41827; SF0165.
AAP15708; AAP15708; S0168.
GeneIDi1024478.
1076599.
KEGGisfl:SF0165.
sfx:S0168.
PATRICi18701288. VBIShiFle31049_0185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN41827.2. Different initiation.
AE014073 Genomic DNA. Translation: AAP15708.1. Different initiation.
RefSeqiNP_706120.4. NC_004337.2.
NP_835903.2. NC_004741.1.

3D structure databases

ProteinModelPortaliP0ABG3.
SMRiP0ABG3. Positions 150-273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF0165.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN41827; AAN41827; SF0165.
AAP15708; AAP15708; S0168.
GeneIDi1024478.
1076599.
KEGGisfl:SF0165.
sfx:S0168.
PATRICi18701288. VBIShiFle31049_0185.

Phylogenomic databases

eggNOGiCOG0575.
HOGENOMiHOG000006168.
KOiK00981.
OrthoDBiEOG6TBHJT.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700930 / 2457T / Serotype 2a.

Entry informationi

Entry nameiCDSA_SHIFL
AccessioniPrimary (citable) accession number: P0ABG3
Secondary accession number(s): P06466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 13, 2007
Last modified: January 7, 2015
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.