Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0ABG1

- CDSA_ECOLI

UniProt

P0ABG1 - CDSA_ECOLI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: EcoCyc

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:CDPDIGLYSYN-MONOMER.
ECOL316407:JW5810-MONOMER.
MetaCyc:CDPDIGLYSYN-MONOMER.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Synonyms:cds
Ordered Locus Names:b0175, JW5810
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG10139. cdsA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121HelicalSequence AnalysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence AnalysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence AnalysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Phosphatidate cytidylyltransferasePRO_0000090734Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP0ABG1.

Interactioni

Protein-protein interaction databases

STRINGi511145.b0175.

Structurei

3D structure databases

ProteinModelPortaliP0ABG1.
SMRiP0ABG1. Positions 150-273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
HOGENOMiHOG000006168.
InParanoidiP0ABG1.
KOiK00981.
OMAiYVFILVW.
OrthoDBiEOG6TBHJT.
PhylomeDBiP0ABG1.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ABG1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKYRLISAF VLIPVVIAAL FLLPPVGFAI VTLVVCMLAA WEWGQLSGFT
60 70 80 90 100
TRSQRVWLAV LCGLLLALML FLLPEYHRNI HQPLVEISLW ASLGWWIVAL
110 120 130 140 150
LLVLFYPGSA AIWRNSKTLR LIFGVLTIVP FFWGMLALRA WHYDENHYSG
160 170 180 190 200
AIWLLYVMIL VWGADSGAYM FGKLFGKHKL APKVSPGKTW QGFIGGLATA
210 220 230 240 250
AVISWGYGMW ANLDVAPVTL LICSIVAALA SVLGDLTESM FKREAGIKDS
260 270 280
GHLIPGHGGI LDRIDSLTAA VPVFACLLLL VFRTL
Length:285
Mass (Da):31,454
Last modified:November 13, 2007 - v2
Checksum:i0D77DCD5EC5FBA9F
GO

Sequence cautioni

The sequence AAA23545.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAB08604.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11330 Genomic DNA. Translation: AAA23545.1. Different initiation.
U70214 Genomic DNA. Translation: AAB08604.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73286.2.
AP009048 Genomic DNA. Translation: BAA77850.2.
PIRiA23898. SYECDG.
RefSeqiNP_414717.2. NC_000913.3.
YP_488477.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73286; AAC73286; b0175.
BAA77850; BAA77850; BAA77850.
GeneIDi12932204.
944876.
KEGGiecj:Y75_p0171.
eco:b0175.
PATRICi32115461. VBIEscCol129921_0182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11330 Genomic DNA. Translation: AAA23545.1 . Different initiation.
U70214 Genomic DNA. Translation: AAB08604.1 . Different initiation.
U00096 Genomic DNA. Translation: AAC73286.2 .
AP009048 Genomic DNA. Translation: BAA77850.2 .
PIRi A23898. SYECDG.
RefSeqi NP_414717.2. NC_000913.3.
YP_488477.1. NC_007779.1.

3D structure databases

ProteinModelPortali P0ABG1.
SMRi P0ABG1. Positions 150-273.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 511145.b0175.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC73286 ; AAC73286 ; b0175 .
BAA77850 ; BAA77850 ; BAA77850 .
GeneIDi 12932204.
944876.
KEGGi ecj:Y75_p0171.
eco:b0175.
PATRICi 32115461. VBIEscCol129921_0182.

Organism-specific databases

EchoBASEi EB0137.
EcoGenei EG10139. cdsA.

Phylogenomic databases

eggNOGi COG0575.
HOGENOMi HOG000006168.
InParanoidi P0ABG1.
KOi K00981.
OMAi YVFILVW.
OrthoDBi EOG6TBHJT.
PhylomeDBi P0ABG1.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .
BioCyci EcoCyc:CDPDIGLYSYN-MONOMER.
ECOL316407:JW5810-MONOMER.
MetaCyc:CDPDIGLYSYN-MONOMER.

Miscellaneous databases

PROi P0ABG1.

Gene expression databases

Genevestigatori P0ABG1.

Family and domain databases

InterProi IPR000374. PC_trans.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PROSITEi PS01315. CDS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and sequencing of the gene for CDP-diglyceride synthetase of Escherichia coli."
    Icho T., Sparrow C.P., Raetz C.R.H.
    J. Biol. Chem. 260:12078-12083(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Systematic sequencing of the Escherichia coli genome: analysis of the 4.0 - 6.0 min (189,987 - 281,416bp) region."
    Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T., Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S., Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Purification and properties of the membrane-bound CDP-diglyceride synthetase from Escherichia coli."
    Sparrow C.P., Raetz C.R.H.
    J. Biol. Chem. 260:12084-12091(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  7. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiCDSA_ECOLI
AccessioniPrimary (citable) accession number: P0ABG1
Secondary accession number(s): P06466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3