Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P0ABG1 (CDSA_ECOLI)

Last modified November 3, 2009. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthetase
    CDP-DAG synthase
Gene names
Name: cdsA
Synonyms: cds
Ordered Locus Names: b0175, JW5810
OrganismEscherichia coli (strain K12) [Complete proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

Subcellular location

Cell inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the CDS family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionphosphatidate cytidylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Phosphatidate cytidylyltransferase
PRO_0000090734

Regions

Transmembrane31 – 5121 Potential
Transmembrane56 – 7621 Potential
Transmembrane93 – 11321 Potential
Transmembrane121 – 14121 Potential
Transmembrane151 – 17121 Potential
Transmembrane190 – 21021 Potential
Transmembrane213 – 23321 Potential
Transmembrane264 – 28421 Potential

Sequences

Sequence LengthMass (Da)Tools
P0ABG1-1 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: 0D77DCD5EC5FBA9F

FASTA28531,454
        10         20         30         40         50         60 
MLKYRLISAF VLIPVVIAAL FLLPPVGFAI VTLVVCMLAA WEWGQLSGFT TRSQRVWLAV 

        70         80         90        100        110        120 
LCGLLLALML FLLPEYHRNI HQPLVEISLW ASLGWWIVAL LLVLFYPGSA AIWRNSKTLR 

       130        140        150        160        170        180 
LIFGVLTIVP FFWGMLALRA WHYDENHYSG AIWLLYVMIL VWGADSGAYM FGKLFGKHKL 

       190        200        210        220        230        240 
APKVSPGKTW QGFIGGLATA AVISWGYGMW ANLDVAPVTL LICSIVAALA SVLGDLTESM 

       250        260        270        280 
FKREAGIKDS GHLIPGHGGI LDRIDSLTAA VPVFACLLLL VFRTL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and sequencing of the gene for CDP-diglyceride synthetase of Escherichia coli."
Icho T., Sparrow C.P., Raetz C.R.H.
J. Biol. Chem. 260:12078-12083(1985) [PubMed: 2995358] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Systematic sequencing of the Escherichia coli genome: analysis of the 4.0 - 6.0 min (189,987 - 281,416bp) region."
Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T., Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S., Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K.
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]"Sequence of minutes 4-25 of Escherichia coli."
Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[5]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[6]"Purification and properties of the membrane-bound CDP-diglyceride synthetase from Escherichia coli."
Sparrow C.P., Raetz C.R.H.
J. Biol. Chem. 260:12084-12091(1985) [PubMed: 2995359] [Abstract]
Cited for: CHARACTERIZATION.
[7]"Global topology analysis of the Escherichia coli inner membrane proteome."
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
Science 308:1321-1323(2005) [PubMed: 15919996] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: K12 / MG1655 / ATCC 47076.

Cross-references

Sequence databases

M11330 Genomic DNA. Translation: AAA23545.1. Different initiation.
U70214 Genomic DNA. Translation: AAB08604.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73286.2.
AP009048 Genomic DNA. Translation: BAA77850.2.
PIRSYECDG. A23898.
RefSeqAP_000835.1.
NP_414717.2.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP0ABG1.

Genome annotation databases

GeneID944876.
GenomeReviewsGene locus JW5810 in contig AP009048_GR.
Gene locus b0175 in contig U00096_GR.
KEGGecj:JW5810.
eco:b0175.

Organism-specific databases

EchoBASEEB0137.
EcoGeneEG10139. cdsA.
CMRSearch...

Phylogenomic databases

HOGENOMP0ABG1.
OMALYVSVPI.

Enzyme and pathway databases

BioCycEcoCyc:CDPDIGLYSYN-MON.
MetaCyc:CDPDIGLYSYN-MON.

Gene expression databases

GenevestigatorP0ABG1.

Family and domain databases

InterProIPR000374. PC_trans.
[Graphical view]
PfamPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDSA_ECOLI
AccessionPrimary (citable) accession number: P0ABG1
Secondary accession number(s): P06466
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 13, 2007
Last modified: November 3, 2009
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents