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P0ABG1 (CDSA_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidate cytidylyltransferase

EC=2.7.7.41
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene names
Name:cdsA
Synonyms:cds
Ordered Locus Names:b0175, JW5810
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

Subcellular location

Cell inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the CDS family.

Sequence caution

The sequence AAA23545.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAB08604.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Phosphatidate cytidylyltransferase
PRO_0000090734

Regions

Transmembrane31 – 5121Helical; Potential
Transmembrane56 – 7621Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane121 – 14121Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane213 – 23321Helical; Potential
Transmembrane264 – 28421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P0ABG1 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: 0D77DCD5EC5FBA9F

FASTA28531,454
        10         20         30         40         50         60 
MLKYRLISAF VLIPVVIAAL FLLPPVGFAI VTLVVCMLAA WEWGQLSGFT TRSQRVWLAV 

        70         80         90        100        110        120 
LCGLLLALML FLLPEYHRNI HQPLVEISLW ASLGWWIVAL LLVLFYPGSA AIWRNSKTLR 

       130        140        150        160        170        180 
LIFGVLTIVP FFWGMLALRA WHYDENHYSG AIWLLYVMIL VWGADSGAYM FGKLFGKHKL 

       190        200        210        220        230        240 
APKVSPGKTW QGFIGGLATA AVISWGYGMW ANLDVAPVTL LICSIVAALA SVLGDLTESM 

       250        260        270        280 
FKREAGIKDS GHLIPGHGGI LDRIDSLTAA VPVFACLLLL VFRTL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and sequencing of the gene for CDP-diglyceride synthetase of Escherichia coli."
Icho T., Sparrow C.P., Raetz C.R.H.
J. Biol. Chem. 260:12078-12083(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Systematic sequencing of the Escherichia coli genome: analysis of the 4.0 - 6.0 min (189,987 - 281,416bp) region."
Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T., Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S., Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K.
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]"Sequence of minutes 4-25 of Escherichia coli."
Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[5]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[6]"Purification and properties of the membrane-bound CDP-diglyceride synthetase from Escherichia coli."
Sparrow C.P., Raetz C.R.H.
J. Biol. Chem. 260:12084-12091(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[7]"Global topology analysis of the Escherichia coli inner membrane proteome."
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: K12 / MG1655 / ATCC 47076.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M11330 Genomic DNA. Translation: AAA23545.1. Different initiation.
U70214 Genomic DNA. Translation: AAB08604.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73286.2.
AP009048 Genomic DNA. Translation: BAA77850.2.
PIRSYECDG. A23898.
RefSeqNP_414717.2. NC_000913.2.
YP_488477.1. NC_007779.1.

3D structure databases

ProteinModelPortalP0ABG1.
ModBaseSearch...

Protein-protein interaction databases

STRING511145.b0175.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC73286; AAC73286; b0175.
BAA77850; BAA77850; BAA77850.
GeneID12932204.
944876.
KEGGecj:Y75_p0171.
eco:b0175.
PATRIC32115461. VBIEscCol129921_0182.

Organism-specific databases

EchoBASEEB0137.
EcoGeneEG10139. cdsA.

Phylogenomic databases

eggNOGCOG0575.
HOGENOMHOG000006168.
KOK00981.
OMAYVFILVW.
ProtClustDBPRK11624.

Enzyme and pathway databases

BioCycEcoCyc:CDPDIGLYSYN-MONOMER.
ECOL316407:JW5810-MONOMER.
MetaCyc:CDPDIGLYSYN-MONOMER.
UniPathwayUPA00557; UER00614.

Gene expression databases

GenevestigatorP0ABG1.

Family and domain databases

InterProIPR000374. PC_trans.
[Graphical view]
PfamPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDSA_ECOLI
AccessionPrimary (citable) accession number: P0ABG1
Secondary accession number(s): P06466
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 13, 2007
Last modified: May 1, 2013
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families