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P0ABG1

- CDSA_ECOLI

UniProt

P0ABG1 - CDSA_ECOLI

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Protein
Phosphatidate cytidylyltransferase
Gene
cdsA, cds, b0175, JW5810
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: EcoCyc
Complete GO annotation...

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:CDPDIGLYSYN-MONOMER.
ECOL316407:JW5810-MONOMER.
MetaCyc:CDPDIGLYSYN-MONOMER.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Synonyms:cds
Ordered Locus Names:b0175, JW5810
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG10139. cdsA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121Helical; Reviewed prediction
Add
BLAST
Transmembranei56 – 7621Helical; Reviewed prediction
Add
BLAST
Transmembranei93 – 11321Helical; Reviewed prediction
Add
BLAST
Transmembranei121 – 14121Helical; Reviewed prediction
Add
BLAST
Transmembranei151 – 17121Helical; Reviewed prediction
Add
BLAST
Transmembranei190 – 21021Helical; Reviewed prediction
Add
BLAST
Transmembranei213 – 23321Helical; Reviewed prediction
Add
BLAST
Transmembranei264 – 28421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Phosphatidate cytidylyltransferase
PRO_0000090734Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP0ABG1.

Interactioni

Protein-protein interaction databases

STRINGi511145.b0175.

Structurei

3D structure databases

ProteinModelPortaliP0ABG1.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
HOGENOMiHOG000006168.
KOiK00981.
OMAiYVFILVW.
OrthoDBiEOG6TBHJT.
PhylomeDBiP0ABG1.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ABG1-1 [UniParc]FASTAAdd to Basket

« Hide

MLKYRLISAF VLIPVVIAAL FLLPPVGFAI VTLVVCMLAA WEWGQLSGFT    50
TRSQRVWLAV LCGLLLALML FLLPEYHRNI HQPLVEISLW ASLGWWIVAL 100
LLVLFYPGSA AIWRNSKTLR LIFGVLTIVP FFWGMLALRA WHYDENHYSG 150
AIWLLYVMIL VWGADSGAYM FGKLFGKHKL APKVSPGKTW QGFIGGLATA 200
AVISWGYGMW ANLDVAPVTL LICSIVAALA SVLGDLTESM FKREAGIKDS 250
GHLIPGHGGI LDRIDSLTAA VPVFACLLLL VFRTL 285
Length:285
Mass (Da):31,454
Last modified:November 13, 2007 - v2
Checksum:i0D77DCD5EC5FBA9F
GO

Sequence cautioni

The sequence AAA23545.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAB08604.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11330 Genomic DNA. Translation: AAA23545.1. Different initiation.
U70214 Genomic DNA. Translation: AAB08604.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73286.2.
AP009048 Genomic DNA. Translation: BAA77850.2.
PIRiA23898. SYECDG.
RefSeqiNP_414717.2. NC_000913.3.
YP_488477.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73286; AAC73286; b0175.
BAA77850; BAA77850; BAA77850.
GeneIDi12932204.
944876.
KEGGiecj:Y75_p0171.
eco:b0175.
PATRICi32115461. VBIEscCol129921_0182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11330 Genomic DNA. Translation: AAA23545.1 . Different initiation.
U70214 Genomic DNA. Translation: AAB08604.1 . Different initiation.
U00096 Genomic DNA. Translation: AAC73286.2 .
AP009048 Genomic DNA. Translation: BAA77850.2 .
PIRi A23898. SYECDG.
RefSeqi NP_414717.2. NC_000913.3.
YP_488477.1. NC_007779.1.

3D structure databases

ProteinModelPortali P0ABG1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 511145.b0175.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC73286 ; AAC73286 ; b0175 .
BAA77850 ; BAA77850 ; BAA77850 .
GeneIDi 12932204.
944876.
KEGGi ecj:Y75_p0171.
eco:b0175.
PATRICi 32115461. VBIEscCol129921_0182.

Organism-specific databases

EchoBASEi EB0137.
EcoGenei EG10139. cdsA.

Phylogenomic databases

eggNOGi COG0575.
HOGENOMi HOG000006168.
KOi K00981.
OMAi YVFILVW.
OrthoDBi EOG6TBHJT.
PhylomeDBi P0ABG1.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .
BioCyci EcoCyc:CDPDIGLYSYN-MONOMER.
ECOL316407:JW5810-MONOMER.
MetaCyc:CDPDIGLYSYN-MONOMER.

Miscellaneous databases

PROi P0ABG1.

Gene expression databases

Genevestigatori P0ABG1.

Family and domain databases

InterProi IPR000374. PC_trans.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PROSITEi PS01315. CDS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and sequencing of the gene for CDP-diglyceride synthetase of Escherichia coli."
    Icho T., Sparrow C.P., Raetz C.R.H.
    J. Biol. Chem. 260:12078-12083(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Systematic sequencing of the Escherichia coli genome: analysis of the 4.0 - 6.0 min (189,987 - 281,416bp) region."
    Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T., Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S., Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Purification and properties of the membrane-bound CDP-diglyceride synthetase from Escherichia coli."
    Sparrow C.P., Raetz C.R.H.
    J. Biol. Chem. 260:12084-12091(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  7. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiCDSA_ECOLI
AccessioniPrimary (citable) accession number: P0ABG1
Secondary accession number(s): P06466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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