Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0ABG1

- CDSA_ECOLI

UniProt

P0ABG1 - CDSA_ECOLI

Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

    Pathwayi

    GO - Molecular functioni

    1. phosphatidate cytidylyltransferase activity Source: EcoCyc

    GO - Biological processi

    1. CDP-diacylglycerol biosynthetic process Source: EcoCyc

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    BioCyciEcoCyc:CDPDIGLYSYN-MONOMER.
    ECOL316407:JW5810-MONOMER.
    MetaCyc:CDPDIGLYSYN-MONOMER.
    UniPathwayiUPA00557; UER00614.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidate cytidylyltransferase (EC:2.7.7.41)
    Alternative name(s):
    CDP-DAG synthase
    CDP-DG synthase
    CDP-diacylglycerol synthase
    Short name:
    CDS
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthase
    CTP:phosphatidate cytidylyltransferase
    Gene namesi
    Name:cdsA
    Synonyms:cds
    Ordered Locus Names:b0175, JW5810
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG10139. cdsA.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: EcoCyc

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285Phosphatidate cytidylyltransferasePRO_0000090734Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP0ABG1.

    Interactioni

    Protein-protein interaction databases

    STRINGi511145.b0175.

    Structurei

    3D structure databases

    ProteinModelPortaliP0ABG1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei93 – 11321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei121 – 14121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CDS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0575.
    HOGENOMiHOG000006168.
    KOiK00981.
    OMAiYVFILVW.
    OrthoDBiEOG6TBHJT.
    PhylomeDBiP0ABG1.

    Family and domain databases

    InterProiIPR000374. PC_trans.
    [Graphical view]
    PfamiPF01148. CTP_transf_1. 1 hit.
    [Graphical view]
    PROSITEiPS01315. CDS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0ABG1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKYRLISAF VLIPVVIAAL FLLPPVGFAI VTLVVCMLAA WEWGQLSGFT    50
    TRSQRVWLAV LCGLLLALML FLLPEYHRNI HQPLVEISLW ASLGWWIVAL 100
    LLVLFYPGSA AIWRNSKTLR LIFGVLTIVP FFWGMLALRA WHYDENHYSG 150
    AIWLLYVMIL VWGADSGAYM FGKLFGKHKL APKVSPGKTW QGFIGGLATA 200
    AVISWGYGMW ANLDVAPVTL LICSIVAALA SVLGDLTESM FKREAGIKDS 250
    GHLIPGHGGI LDRIDSLTAA VPVFACLLLL VFRTL 285
    Length:285
    Mass (Da):31,454
    Last modified:November 13, 2007 - v2
    Checksum:i0D77DCD5EC5FBA9F
    GO

    Sequence cautioni

    The sequence AAA23545.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAB08604.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11330 Genomic DNA. Translation: AAA23545.1. Different initiation.
    U70214 Genomic DNA. Translation: AAB08604.1. Different initiation.
    U00096 Genomic DNA. Translation: AAC73286.2.
    AP009048 Genomic DNA. Translation: BAA77850.2.
    PIRiA23898. SYECDG.
    RefSeqiNP_414717.2. NC_000913.3.
    YP_488477.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC73286; AAC73286; b0175.
    BAA77850; BAA77850; BAA77850.
    GeneIDi12932204.
    944876.
    KEGGiecj:Y75_p0171.
    eco:b0175.
    PATRICi32115461. VBIEscCol129921_0182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11330 Genomic DNA. Translation: AAA23545.1 . Different initiation.
    U70214 Genomic DNA. Translation: AAB08604.1 . Different initiation.
    U00096 Genomic DNA. Translation: AAC73286.2 .
    AP009048 Genomic DNA. Translation: BAA77850.2 .
    PIRi A23898. SYECDG.
    RefSeqi NP_414717.2. NC_000913.3.
    YP_488477.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P0ABG1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 511145.b0175.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC73286 ; AAC73286 ; b0175 .
    BAA77850 ; BAA77850 ; BAA77850 .
    GeneIDi 12932204.
    944876.
    KEGGi ecj:Y75_p0171.
    eco:b0175.
    PATRICi 32115461. VBIEscCol129921_0182.

    Organism-specific databases

    EchoBASEi EB0137.
    EcoGenei EG10139. cdsA.

    Phylogenomic databases

    eggNOGi COG0575.
    HOGENOMi HOG000006168.
    KOi K00981.
    OMAi YVFILVW.
    OrthoDBi EOG6TBHJT.
    PhylomeDBi P0ABG1.

    Enzyme and pathway databases

    UniPathwayi UPA00557 ; UER00614 .
    BioCyci EcoCyc:CDPDIGLYSYN-MONOMER.
    ECOL316407:JW5810-MONOMER.
    MetaCyc:CDPDIGLYSYN-MONOMER.

    Miscellaneous databases

    PROi P0ABG1.

    Gene expression databases

    Genevestigatori P0ABG1.

    Family and domain databases

    InterProi IPR000374. PC_trans.
    [Graphical view ]
    Pfami PF01148. CTP_transf_1. 1 hit.
    [Graphical view ]
    PROSITEi PS01315. CDS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of the gene for CDP-diglyceride synthetase of Escherichia coli."
      Icho T., Sparrow C.P., Raetz C.R.H.
      J. Biol. Chem. 260:12078-12083(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Systematic sequencing of the Escherichia coli genome: analysis of the 4.0 - 6.0 min (189,987 - 281,416bp) region."
      Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T., Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S., Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K.
      Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    3. "Sequence of minutes 4-25 of Escherichia coli."
      Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    6. "Purification and properties of the membrane-bound CDP-diglyceride synthetase from Escherichia coli."
      Sparrow C.P., Raetz C.R.H.
      J. Biol. Chem. 260:12084-12091(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    7. "Global topology analysis of the Escherichia coli inner membrane proteome."
      Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
      Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: K12 / MG1655 / ATCC 47076.

    Entry informationi

    Entry nameiCDSA_ECOLI
    AccessioniPrimary (citable) accession number: P0ABG1
    Secondary accession number(s): P06466
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3