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Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase (plsC)
  3. Phosphatidate cytidylyltransferase (cdsA)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

  • phosphatidate cytidylyltransferase activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:CDPDIGLYSYN-MONOMER
MetaCyc:CDPDIGLYSYN-MONOMER
UniPathwayiUPA00557; UER00614

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Synonyms:cds
Ordered Locus Names:b0175, JW5810
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10139 cdsA

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000907341 – 285Phosphatidate cytidylyltransferaseAdd BLAST285

Proteomic databases

PaxDbiP0ABG1
PRIDEiP0ABG1

Interactioni

Protein-protein interaction databases

BioGridi4261198, 7 interactors
STRINGi316385.ECDH10B_0155

Structurei

3D structure databases

ProteinModelPortaliP0ABG1
SMRiP0ABG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105KNE Bacteria
COG0575 LUCA
HOGENOMiHOG000006168
InParanoidiP0ABG1
KOiK00981
OMAiWEWGRLN
PhylomeDBiP0ABG1

Family and domain databases

InterProiView protein in InterPro
IPR000374 PC_trans
PROSITEiView protein in PROSITE
PS01315 CDS, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKYRLISAF VLIPVVIAAL FLLPPVGFAI VTLVVCMLAA WEWGQLSGFT
60 70 80 90 100
TRSQRVWLAV LCGLLLALML FLLPEYHRNI HQPLVEISLW ASLGWWIVAL
110 120 130 140 150
LLVLFYPGSA AIWRNSKTLR LIFGVLTIVP FFWGMLALRA WHYDENHYSG
160 170 180 190 200
AIWLLYVMIL VWGADSGAYM FGKLFGKHKL APKVSPGKTW QGFIGGLATA
210 220 230 240 250
AVISWGYGMW ANLDVAPVTL LICSIVAALA SVLGDLTESM FKREAGIKDS
260 270 280
GHLIPGHGGI LDRIDSLTAA VPVFACLLLL VFRTL
Length:285
Mass (Da):31,454
Last modified:November 13, 2007 - v2
Checksum:i0D77DCD5EC5FBA9F
GO

Sequence cautioni

The sequence AAA23545 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAB08604 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11330 Genomic DNA Translation: AAA23545.1 Different initiation.
U70214 Genomic DNA Translation: AAB08604.1 Different initiation.
U00096 Genomic DNA Translation: AAC73286.2
AP009048 Genomic DNA Translation: BAA77850.2
PIRiA23898 SYECDG
RefSeqiNP_414717.2, NC_000913.3
WP_000922446.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73286; AAC73286; b0175
BAA77850; BAA77850; BAA77850
GeneIDi944876
KEGGiecj:JW5810
eco:b0175
PATRICifig|511145.12.peg.182

Similar proteinsi

Entry informationi

Entry nameiCDSA_ECOLI
AccessioniPrimary (citable) accession number: P0ABG1
Secondary accession number(s): P06466
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health