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P0ABF2

- PCNB_ECOL6

UniProt

P0ABF2 - PCNB_ECOL6

Protein

Poly(A) polymerase I

Gene

pcnB

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (19 Sep 2006)
      Previous versions | rss
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    Functioni

    Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.UniRule annotation

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei80 – 801UniRule annotation
    Active sitei82 – 821UniRule annotation
    Active sitei162 – 1621UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. polynucleotide adenylyltransferase activity Source: UniProtKB-HAMAP
    3. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA polyadenylation Source: InterPro
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing, Transcription

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase IUniRule annotation (EC:2.7.7.19UniRule annotation)
    Short name:
    PAP IUniRule annotation
    Gene namesi
    Name:pcnBUniRule annotation
    Ordered Locus Names:c0176
    OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
    Taxonomic identifieri199310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001410: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 465465Poly(A) polymerase IPRO_0000139092Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi199310.c0176.

    Structurei

    3D structure databases

    ProteinModelPortaliP0ABF2.
    SMRiP0ABF2. Positions 28-438.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000256527.
    KOiK00970.
    OMAiRFMAKLD.
    OrthoDBiEOG6PZX7Q.

    Family and domain databases

    HAMAPiMF_00957. PolyA_pol.
    InterProiIPR002646. PolA_pol_head_dom.
    IPR010206. PolA_pol_I.
    IPR025866. PolyA_pol_arg_C_dom.
    [Graphical view]
    PfamiPF01743. PolyA_pol. 1 hit.
    PF12626. PolyA_pol_arg_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01942. pcnB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0ABF2-1 [UniParc]FASTAAdd to Basket

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    MFTRVANFCR KVLSREESEA EQAVARPQVT VIPREQHAIS RKDISENALK    50
    VMYRLNKAGY EAWLVGGGVR DLLLGKKPKD FDVTTNATPE QVRKLFRNCR 100
    LVGRRFRLAH VMFGPEIIEV ATFRGHHEGN VSDRTTSQRG QNGMLLRDNI 150
    FGSIEEDAQR RDFTINSLYY SVADFTVRDY VGGMKDLKDG VIRLIGNPET 200
    RYREDPVRML RAVRFAAKLG MRISPETAEP IPRLATLLND IPPARLFEES 250
    LKLLQAGYGY ETYKLLCEYH LFQPLFPTIT RYFTENGDSP MERIIEQVLK 300
    NTDTRIHNDM RVNPAFLFAA MFWYPLLETA QKIAQESGLT YHDAFALAMN 350
    DVLDEACRSL AIPKRLTTLT RDIWQLQLRM SRRQGKRAWK LLEHPKFRAA 400
    YDLLALRAEV ERNAELQRLV KWWGEFQVSA PPDQKGMLNE LDEEPSPRRR 450
    TRRPRKRAPR REGTA 465
    Length:465
    Mass (Da):53,871
    Last modified:September 19, 2006 - v2
    Checksum:i0FAE30F2F95FB76E
    GO

    Sequence cautioni

    The sequence AAN78670.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN78670.1. Different initiation.
    RefSeqiNP_752126.1. NC_004431.1.

    Genome annotation databases

    EnsemblBacteriaiAAN78670; AAN78670; c0176.
    GeneIDi1037253.
    KEGGiecc:c0176.
    PATRICi18278422. VBIEscCol75197_0166.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN78670.1 . Different initiation.
    RefSeqi NP_752126.1. NC_004431.1.

    3D structure databases

    ProteinModelPortali P0ABF2.
    SMRi P0ABF2. Positions 28-438.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 199310.c0176.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN78670 ; AAN78670 ; c0176 .
    GeneIDi 1037253.
    KEGGi ecc:c0176.
    PATRICi 18278422. VBIEscCol75197_0166.

    Phylogenomic databases

    HOGENOMi HOG000256527.
    KOi K00970.
    OMAi RFMAKLD.
    OrthoDBi EOG6PZX7Q.

    Family and domain databases

    HAMAPi MF_00957. PolyA_pol.
    InterProi IPR002646. PolA_pol_head_dom.
    IPR010206. PolA_pol_I.
    IPR025866. PolyA_pol_arg_C_dom.
    [Graphical view ]
    Pfami PF01743. PolyA_pol. 1 hit.
    PF12626. PolyA_pol_arg_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01942. pcnB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFT073 / ATCC 700928 / UPEC.

    Entry informationi

    Entry nameiPCNB_ECOL6
    AccessioniPrimary (citable) accession number: P0ABF2
    Secondary accession number(s): P13685, P78050, Q8X910
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: September 19, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3