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Protein

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Gene

accB

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.By similarity

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Biotin

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin carboxyl carrier protein of acetyl-CoA carboxylase
Short name:
BCCP
Gene namesi
Name:accB
Ordered Locus Names:SF3293, S3510
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001468111 – 156Biotin carboxyl carrier protein of acetyl-CoA carboxylaseAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122N6-biotinyllysinePROSITE-ProRule annotationBy similarity1

Proteomic databases

PaxDbiP0ABE1.
PRIDEiP0ABE1.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi198214.SF3293.

Structurei

3D structure databases

ProteinModelPortaliP0ABE1.
SMRiP0ABE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 156Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST84

Sequence similaritiesi

Contains 1 biotinyl-binding domain.PROSITE-ProRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105KM4. Bacteria.
COG0511. LUCA.
HOGENOMiHOG000008875.
KOiK02160.
OMAiKMFNQIE.

Family and domain databases

InterProiIPR001249. AcCoA_biotinCC.
IPR001882. Biotin_BS.
IPR000089. Biotin_lipoyl.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00364. Biotin_lipoyl. 1 hit.
[Graphical view]
PRINTSiPR01071. ACOABIOTINCC.
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00531. BCCP. 1 hit.
PROSITEiPS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ABE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIRKIKKLI ELVEESGISE LEISEGEESV RISRAAPAAS FPVMQQAYAA
60 70 80 90 100
PMMQQPAQSN AAAPATVPSM EAPAAAEISG HIVRSPMVGT FYRTPSPDAK
110 120 130 140 150
AFIEVGQKVN VGDTLCIVEA MKMMNQIEAD KSGTVKAILV ESGQPVEFDE

PLVVIE
Length:156
Mass (Da):16,687
Last modified:October 25, 2005 - v1
Checksum:i05FFDCB912A683A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN44757.1.
AE014073 Genomic DNA. Translation: AAP18568.1.
RefSeqiNP_709050.1. NC_004337.2.
WP_000354622.1. NZ_LVJC01000032.1.

Genome annotation databases

EnsemblBacteriaiAAN44757; AAN44757; SF3293.
AAP18568; AAP18568; S3510.
GeneIDi1027068.
KEGGisfl:SF3293.
sft:NCTC1_03570.
sfx:S3510.
PATRICi18708789. VBIShiFle31049_3840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN44757.1.
AE014073 Genomic DNA. Translation: AAP18568.1.
RefSeqiNP_709050.1. NC_004337.2.
WP_000354622.1. NZ_LVJC01000032.1.

3D structure databases

ProteinModelPortaliP0ABE1.
SMRiP0ABE1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF3293.

Proteomic databases

PaxDbiP0ABE1.
PRIDEiP0ABE1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN44757; AAN44757; SF3293.
AAP18568; AAP18568; S3510.
GeneIDi1027068.
KEGGisfl:SF3293.
sft:NCTC1_03570.
sfx:S3510.
PATRICi18708789. VBIShiFle31049_3840.

Phylogenomic databases

eggNOGiENOG4105KM4. Bacteria.
COG0511. LUCA.
HOGENOMiHOG000008875.
KOiK02160.
OMAiKMFNQIE.

Enzyme and pathway databases

UniPathwayiUPA00094.

Family and domain databases

InterProiIPR001249. AcCoA_biotinCC.
IPR001882. Biotin_BS.
IPR000089. Biotin_lipoyl.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00364. Biotin_lipoyl. 1 hit.
[Graphical view]
PRINTSiPR01071. ACOABIOTINCC.
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00531. BCCP. 1 hit.
PROSITEiPS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCCP_SHIFL
AccessioniPrimary (citable) accession number: P0ABE1
Secondary accession number(s): P02905
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 25, 2005
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.