Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Gene

accB

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.By similarity

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandBiotin

Enzyme and pathway databases

UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin carboxyl carrier protein of acetyl-CoA carboxylase
Short name:
BCCP
Gene namesi
Name:accB
Ordered Locus Names:Z4615, ECs4127
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001468061 – 156Biotin carboxyl carrier protein of acetyl-CoA carboxylaseAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122N6-biotinyllysinePROSITE-ProRule annotationBy similarity1

Proteomic databases

PRIDEiP0ABE0

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi155864.Z4615

Structurei

3D structure databases

DisProtiDP00415
ProteinModelPortaliP0ABE0
SMRiP0ABE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 156Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST84

Phylogenomic databases

eggNOGiENOG4105KM4 Bacteria
COG0511 LUCA
HOGENOMiHOG000008875
KOiK02160
OMAiIKSPIIG

Family and domain databases

InterProiView protein in InterPro
IPR001249 AcCoA_biotinCC
IPR001882 Biotin_BS
IPR000089 Biotin_lipoyl
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00364 Biotin_lipoyl, 1 hit
PRINTSiPR01071 ACOABIOTINCC
SUPFAMiSSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR00531 BCCP, 1 hit
PROSITEiView protein in PROSITE
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIRKIKKLI ELVEESGISE LEISEGEESV RISRAAPAAS FPVMQQAYAA
60 70 80 90 100
PMMQQPAQSN AAAPATVPSM EAPAAAEISG HIVRSPMVGT FYRTPSPDAK
110 120 130 140 150
AFIEVGQKVN VGDTLCIVEA MKMMNQIEAD KSGTVKAILV ESGQPVEFDE

PLVVIE
Length:156
Mass (Da):16,687
Last modified:October 25, 2005 - v1
Checksum:i05FFDCB912A683A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG58383.1
BA000007 Genomic DNA Translation: BAB37550.1
PIRiC85990
G91144
RefSeqiNP_312154.1, NC_002695.1
WP_000354622.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG58383; AAG58383; Z4615
BAB37550; BAB37550; BAB37550
GeneIDi916025
KEGGiece:Z4615
ecs:ECs4127
PATRICifig|386585.9.peg.4310

Similar proteinsi

Entry informationi

Entry nameiBCCP_ECO57
AccessioniPrimary (citable) accession number: P0ABE0
Secondary accession number(s): P02905
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 25, 2005
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health