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Protein

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Gene

accB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.1 Publication

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

  • acetyl-CoA carboxylase activity Source: EcoliWiki
  • biotin binding Source: EcoCyc

GO - Biological processi

  • fatty acid biosynthetic process Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Biotin

Enzyme and pathway databases

BioCyciEcoCyc:BCCP-MONOMER.
ECOL316407:JW3223-MONOMER.
MetaCyc:BCCP-MONOMER.
RETL1328306-WGS:GSTH-1923-MONOMER.
BRENDAi6.4.1.2. 2026.
SABIO-RKP0ABD8.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin carboxyl carrier protein of acetyl-CoA carboxylase1 Publication
Short name:
BCCP1 Publication
Gene namesi
Name:accB
Synonyms:fabE
Ordered Locus Names:b3255, JW3223
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10275. accB.

Subcellular locationi

GO - Cellular componenti

  • acetyl-CoA carboxylase complex Source: EcoCyc
  • cytoplasm Source: EcoliWiki
  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156Biotin carboxyl carrier protein of acetyl-CoA carboxylasePRO_0000146805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei122 – 1221N6-biotinyllysinePROSITE-ProRule annotation1 Publication

Proteomic databases

EPDiP0ABD8.
PaxDbiP0ABD8.
PRIDEiP0ABD8.

2D gel databases

SWISS-2DPAGEP0ABD8.

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
accCP241826EBI-542320,EBI-542308

Protein-protein interaction databases

BioGridi4259533. 408 interactions.
DIPiDIP-48007N.
IntActiP0ABD8. 12 interactions.
MINTiMINT-1292848.
STRINGi511145.b3255.

Structurei

Secondary structure

1
156
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi72 – 765Combined sources
Beta strandi80 – 845Combined sources
Beta strandi86 – 9611Combined sources
Beta strandi114 – 1207Combined sources
Beta strandi123 – 1286Combined sources
Beta strandi133 – 1386Combined sources
Beta strandi142 – 1454Combined sources
Beta strandi148 – 1503Combined sources
Beta strandi151 – 1555Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A6XNMR-A70-156[»]
1BDOX-ray1.80A77-156[»]
1K67model-B77-155[»]
1K69model-B77-156[»]
2BDONMR-A77-156[»]
3BDONMR-A75-156[»]
4HR7X-ray2.50B/D/G/I1-156[»]
ProteinModelPortaliP0ABD8.
SMRiP0ABD8. Positions 77-156.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ABD8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini73 – 15684Biotinyl-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 biotinyl-binding domain.PROSITE-ProRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105KM4. Bacteria.
COG0511. LUCA.
HOGENOMiHOG000008875.
InParanoidiP0ABD8.
KOiK02160.
OMAiKMFNQIE.
PhylomeDBiP0ABD8.

Family and domain databases

InterProiIPR001249. AcCoA_biotinCC.
IPR001882. Biotin_BS.
IPR000089. Biotin_lipoyl.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00364. Biotin_lipoyl. 1 hit.
[Graphical view]
PRINTSiPR01071. ACOABIOTINCC.
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00531. BCCP. 1 hit.
PROSITEiPS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ABD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIRKIKKLI ELVEESGISE LEISEGEESV RISRAAPAAS FPVMQQAYAA
60 70 80 90 100
PMMQQPAQSN AAAPATVPSM EAPAAAEISG HIVRSPMVGT FYRTPSPDAK
110 120 130 140 150
AFIEVGQKVN VGDTLCIVEA MKMMNQIEAD KSGTVKAILV ESGQPVEFDE

PLVVIE
Length:156
Mass (Da):16,687
Last modified:October 25, 2005 - v1
Checksum:i05FFDCB912A683A3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131D → N (PubMed:2575489).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14825 Genomic DNA. Translation: CAA32933.1.
M80458 Genomic DNA. Translation: AAA23408.1.
M32214 Genomic DNA. Translation: AAA23744.1.
M83198 Genomic DNA. Translation: AAA23745.1.
U18997 Genomic DNA. Translation: AAA58058.1.
U00096 Genomic DNA. Translation: AAC76287.1.
AP009048 Genomic DNA. Translation: BAE77296.1.
S52932 mRNA. Translation: AAB24892.1.
M79446 Genomic DNA. No translation available.
PIRiA93687. BKEC9.
RefSeqiNP_417721.1. NC_000913.3.
WP_000354622.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76287; AAC76287; b3255.
BAE77296; BAE77296; BAE77296.
GeneIDi947758.
KEGGiecj:JW3223.
eco:b3255.
PATRICi32121940. VBIEscCol129921_3354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14825 Genomic DNA. Translation: CAA32933.1.
M80458 Genomic DNA. Translation: AAA23408.1.
M32214 Genomic DNA. Translation: AAA23744.1.
M83198 Genomic DNA. Translation: AAA23745.1.
U18997 Genomic DNA. Translation: AAA58058.1.
U00096 Genomic DNA. Translation: AAC76287.1.
AP009048 Genomic DNA. Translation: BAE77296.1.
S52932 mRNA. Translation: AAB24892.1.
M79446 Genomic DNA. No translation available.
PIRiA93687. BKEC9.
RefSeqiNP_417721.1. NC_000913.3.
WP_000354622.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A6XNMR-A70-156[»]
1BDOX-ray1.80A77-156[»]
1K67model-B77-155[»]
1K69model-B77-156[»]
2BDONMR-A77-156[»]
3BDONMR-A75-156[»]
4HR7X-ray2.50B/D/G/I1-156[»]
ProteinModelPortaliP0ABD8.
SMRiP0ABD8. Positions 77-156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259533. 408 interactions.
DIPiDIP-48007N.
IntActiP0ABD8. 12 interactions.
MINTiMINT-1292848.
STRINGi511145.b3255.

2D gel databases

SWISS-2DPAGEP0ABD8.

Proteomic databases

EPDiP0ABD8.
PaxDbiP0ABD8.
PRIDEiP0ABD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76287; AAC76287; b3255.
BAE77296; BAE77296; BAE77296.
GeneIDi947758.
KEGGiecj:JW3223.
eco:b3255.
PATRICi32121940. VBIEscCol129921_3354.

Organism-specific databases

EchoBASEiEB0271.
EcoGeneiEG10275. accB.

Phylogenomic databases

eggNOGiENOG4105KM4. Bacteria.
COG0511. LUCA.
HOGENOMiHOG000008875.
InParanoidiP0ABD8.
KOiK02160.
OMAiKMFNQIE.
PhylomeDBiP0ABD8.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciEcoCyc:BCCP-MONOMER.
ECOL316407:JW3223-MONOMER.
MetaCyc:BCCP-MONOMER.
RETL1328306-WGS:GSTH-1923-MONOMER.
BRENDAi6.4.1.2. 2026.
SABIO-RKP0ABD8.

Miscellaneous databases

EvolutionaryTraceiP0ABD8.
PROiP0ABD8.

Family and domain databases

InterProiIPR001249. AcCoA_biotinCC.
IPR001882. Biotin_BS.
IPR000089. Biotin_lipoyl.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00364. Biotin_lipoyl. 1 hit.
[Graphical view]
PRINTSiPR01071. ACOABIOTINCC.
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00531. BCCP. 1 hit.
PROSITEiPS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCCP_ECOLI
AccessioniPrimary (citable) accession number: P0ABD8
Secondary accession number(s): P02905, Q2M8W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 25, 2005
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.