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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene

accA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Biotin carboxylase (accC), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECOO157:ACCA-MONOMER.
UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotation (EC:6.4.1.2UniRule annotation)
Short name:
ACCase subunit alphaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation
Gene namesi
Name:accAUniRule annotation
Ordered Locus Names:Z0197, ECs0187
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001467752 – 319Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaAdd BLAST318

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotation

Protein-protein interaction databases

MINTiMINT-1228640.
STRINGi155864.Z0197.

Structurei

3D structure databases

ProteinModelPortaliP0ABD6.
SMRiP0ABD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 296CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST262

Sequence similaritiesi

Belongs to the AccA family.UniRule annotation
Contains 1 CoA carboxyltransferase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107QM9. Bacteria.
COG0825. LUCA.
HOGENOMiHOG000273832.
KOiK01962.
OMAiHSVYTVA.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00823. AcetylCoA_CT_alpha. 1 hit.
InterProiIPR001095. Acetyl_CoA_COase_a_su.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
[Graphical view]
PfamiPF03255. ACCA. 1 hit.
[Graphical view]
PRINTSiPR01069. ACCCTRFRASEA.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00513. accA. 1 hit.
PROSITEiPS50989. COA_CT_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ABD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNFLDFEQ PIAELEAKID SLTAVSRQDE KLDINIDEEV HRLREKSVEL
60 70 80 90 100
TRKIFADLGA WQIAQLARHP QRPYTLDYVR LAFDEFDELA GDRAYADDKA
110 120 130 140 150
IVGGIARLDG RPVMIIGHQK GRETKEKIRR NFGMPAPEGY RKALRLMQMA
160 170 180 190 200
ERFKMPIITF IDTPGAYPGV GAEERGQSEA IARNLREMSR LGVPVVCTVI
210 220 230 240 250
GEGGSGGALA IGVGDKVNML QYSTYSVISP EGCASILWKS ADKAPLAAEA
260 270 280 290 300
MGIIAPRLKE LKLIDSIIPE PLGGAHRNPE AMAASLKAQL LADLADLDVL
310
STEDLKNRRY QRLMSYGYA
Length:319
Mass (Da):35,242
Last modified:January 23, 2007 - v2
Checksum:iA810DE891CEA2B4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG54487.1.
BA000007 Genomic DNA. Translation: BAB33610.1.
PIRiC85503.
C90652.
RefSeqiNP_308214.1. NC_002695.1.
WP_000055741.1. NZ_LPWC02000002.1.

Genome annotation databases

EnsemblBacteriaiAAG54487; AAG54487; Z0197.
BAB33610; BAB33610; BAB33610.
GeneIDi913907.
KEGGiece:Z0197.
ecs:ECs0187.
PATRICi18349320. VBIEscCol44059_0190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG54487.1.
BA000007 Genomic DNA. Translation: BAB33610.1.
PIRiC85503.
C90652.
RefSeqiNP_308214.1. NC_002695.1.
WP_000055741.1. NZ_LPWC02000002.1.

3D structure databases

ProteinModelPortaliP0ABD6.
SMRiP0ABD6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1228640.
STRINGi155864.Z0197.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG54487; AAG54487; Z0197.
BAB33610; BAB33610; BAB33610.
GeneIDi913907.
KEGGiece:Z0197.
ecs:ECs0187.
PATRICi18349320. VBIEscCol44059_0190.

Phylogenomic databases

eggNOGiENOG4107QM9. Bacteria.
COG0825. LUCA.
HOGENOMiHOG000273832.
KOiK01962.
OMAiHSVYTVA.

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.
BioCyciECOO157:ACCA-MONOMER.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00823. AcetylCoA_CT_alpha. 1 hit.
InterProiIPR001095. Acetyl_CoA_COase_a_su.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
[Graphical view]
PfamiPF03255. ACCA. 1 hit.
[Graphical view]
PRINTSiPR01069. ACCCTRFRASEA.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00513. accA. 1 hit.
PROSITEiPS50989. COA_CT_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACCA_ECO57
AccessioniPrimary (citable) accession number: P0ABD6
Secondary accession number(s): P30867
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.