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P0ABD6 (ACCA_ECO57) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Short name=ACCase subunit alpha
Short name=Acetyl-CoA carboxylase carboxyltransferase subunit alpha
EC=6.4.1.2
Gene names
Name:accA
Ordered Locus Names:Z0197, ECs0187
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA By similarity. HAMAP-Rule MF_00823

Catalytic activity

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. HAMAP-Rule MF_00823

Pathway

Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. HAMAP-Rule MF_00823

Subunit structure

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD) By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the AccA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 319318Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha HAMAP-Rule MF_00823
PRO_0000146775

Sequences

Sequence LengthMass (Da)Tools
P0ABD6 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: A810DE891CEA2B4F

FASTA31935,242
        10         20         30         40         50         60 
MSLNFLDFEQ PIAELEAKID SLTAVSRQDE KLDINIDEEV HRLREKSVEL TRKIFADLGA 

        70         80         90        100        110        120 
WQIAQLARHP QRPYTLDYVR LAFDEFDELA GDRAYADDKA IVGGIARLDG RPVMIIGHQK 

       130        140        150        160        170        180 
GRETKEKIRR NFGMPAPEGY RKALRLMQMA ERFKMPIITF IDTPGAYPGV GAEERGQSEA 

       190        200        210        220        230        240 
IARNLREMSR LGVPVVCTVI GEGGSGGALA IGVGDKVNML QYSTYSVISP EGCASILWKS 

       250        260        270        280        290        300 
ADKAPLAAEA MGIIAPRLKE LKLIDSIIPE PLGGAHRNPE AMAASLKAQL LADLADLDVL 

       310 
STEDLKNRRY QRLMSYGYA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005174 Genomic DNA. Translation: AAG54487.1.
BA000007 Genomic DNA. Translation: BAB33610.1.
PIRC85503.
C90652.
RefSeqNP_285879.1. NC_002655.2.
NP_308214.1. NC_002695.1.

3D structure databases

ProteinModelPortalP0ABD6.
SMRP0ABD6. Positions 4-319.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-1228640.
STRING155864.Z0197.

Proteomic databases

PRIDEP0ABD6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG54487; AAG54487; Z0197.
BAB33610; BAB33610; BAB33610.
GeneID913907.
956919.
KEGGece:Z0197.
ecs:ECs0187.
PATRIC18349320. VBIEscCol44059_0190.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0825.
HOGENOMHOG000273832.
KOK01962.
OMAQLTKDIY.
ProtClustDBPRK05724.

Enzyme and pathway databases

BioCycECOL386585:GJFA-185-MONOMER.
UniPathwayUPA00655; UER00711.

Family and domain databases

HAMAPMF_00823. AcetylCoA_CT_alpha.
InterProIPR001095. Acetyl_CoA_COase_a_su.
IPR011763. COA_CT_C.
[Graphical view]
PANTHERPTHR22855:SF3. PTHR22855:SF3. 1 hit.
PfamPF03255. ACCA. 1 hit.
[Graphical view]
PRINTSPR01069. ACCCTRFRASEA.
TIGRFAMsTIGR00513. accA. 1 hit.
PROSITEPS50989. COA_CT_CTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACCA_ECO57
AccessionPrimary (citable) accession number: P0ABD6
Secondary accession number(s): P30867
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 23, 2007
Last modified: May 1, 2013
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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