Reviewed, UniProtKB/Swiss-Prot P0ABD4 (BFR_ECOL6)

Names and origin

Protein names

Recommended name:
    Bacterioferritin
      Short name=BFR
Alternative name(s):
    Cytochrome b-1
    Cytochrome b-557

Gene names

Name:	bfr
Ordered Locus Names:	c4107

Organism

Escherichia coli O6 [Complete proteome] [HAMAP]

Taxonomic identifier

217992 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May perform analogous functions in iron detoxification and storage to that of animal ferritins By similarity.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity.
Subunit structure	Oligomer of 24 identical subunits By similarity.
Miscellaneous	The di-iron binding site functions as active site where iron ions are oxidized from Fe2+ to Fe3+ before they are stored By similarity.
Sequence similarities	Belongs to the bacterioferritin family. Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
Biological process	Iron storage
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW iron ion transport Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: InterPro
Molecular function	ferric iron binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	Bacterioferritin		PRO_0000192593
Regions
	Domain	1 – 145	145	Ferritin-like diiron
Sites
	Metal binding	18	1	Iron 1 By similarity
	Metal binding	51	1	Iron 1 By similarity
	Metal binding	51	1	Iron 2 By similarity
	Metal binding	52	1	Iron (heme axial ligand) By similarity
	Metal binding	54	1	Iron 1 By similarity
	Metal binding	94	1	Iron 2 By similarity
	Metal binding	127	1	Iron 1 By similarity
	Metal binding	127	1	Iron 2 By similarity
	Metal binding	130	1	Iron 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0ABD4-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: A6C86CE1CD8F865A	FASTA	158	18,495
	10 20 30 40 50 60 MKGDTKVINY LNKLLGNELV AINQYFLHAR MFKNWGLKRL NDVEYHESID EMKHADRYIE 70 80 90 100 110 120 RILFLEGLPN LQDLGKLNIG EDVEEMLRSD LALELDGAKN LREAIGYADS VHDYVSRDMM 130 140 150 IEILRDEEGH IDWLETELDL IQKMGLQNYL QAQIREEG

References

[1]

"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli." Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R. Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed: 12471157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O6:H1 / CFT073 / ATCC 700928 / UPEC.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014075 Genomic DNA. Translation: AAN82545.1.
RefSeq	NP_755971.1.
3D structure databases
SMR	P0ABD4. Positions 1-158.
ModBase	Search...
Proteomic databases
PRIDE	P0ABD4.
Genome annotation databases
GeneID	1036151.
GenomeReviews	Gene locus c4107 in contig AE014075_GR.
KEGG	ecc:c4107.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P0ABD4.
OMA	FLDGFPN
Family and domain databases
InterPro	IPR002024. Bacterioferritin. IPR009040. Ferritin-like. IPR009078. Ferritin/RR-like. IPR008331. Ferritin_Dps. IPR012347. Ferritin_rel. [Graphical view]
Gene3D	G3DSA:1.20.1260.10. Ferritin_rel. 1 hit.
Pfam	PF00210. Ferritin. 1 hit. [Graphical view]
PIRSF	PIRSF002560. Bacterioferritin. 1 hit.
PRINTS	PR00601. BACFERRITIN.
TIGRFAMs	TIGR00754. bfr. 1 hit.
PROSITE	PS00549. BACTERIOFERRITIN. 1 hit. PS50905. FERRITIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BFR_ECOL6

Accession

Primary (citable) accession number: P0ABD4
Secondary accession number(s): O68931, P11056

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	October 25, 2005
Last modified:	November 24, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)