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Protein

High-affinity choline transport protein

Gene

betT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

High-affinity uptake of choline driven by a proton-motive force.1 Publication

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in the pathway betaine biosynthesis via choline pathway, which is part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processStress response, Transport

Enzyme and pathway databases

BioCyciEcoCyc:BETT-MONOMER
MetaCyc:BETT-MONOMER
UniPathwayiUPA00529

Protein family/group databases

TCDBi2.A.15.1.4 the betaine/carnitine/choline transporter (bcct) family

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity choline transport proteinCurated
Gene namesi
Name:betT1 Publication
Ordered Locus Names:b0314, JW0306
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10112 betT

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Transmembranei477 – 497HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002014841 – 677High-affinity choline transport proteinAdd BLAST677

Proteomic databases

PaxDbiP0ABC9
PRIDEiP0ABC9

Expressioni

Inductioni

By osmotic stress. Choline is required for full expression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262802, 218 interactors
STRINGi316385.ECDH10B_0301

Structurei

3D structure databases

ProteinModelPortaliP0ABC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C94 Bacteria
COG1292 LUCA
HOGENOMiHOG000053241
InParanoidiP0ABC9
KOiK02168
OMAiFIMAGLY
PhylomeDBiP0ABC9

Family and domain databases

InterProiView protein in InterPro
IPR018093 BCCT_CS
IPR000060 BCCT_transptr
PANTHERiPTHR30047 PTHR30047, 1 hit
PfamiView protein in Pfam
PF02028 BCCT, 1 hit
TIGRFAMsiTIGR00842 bcct, 1 hit
PROSITEiView protein in PROSITE
PS01303 BCCT, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLSHSREK DKINPVVFYT SAGLILLFSL TTILFRDFSA LWIGRTLDWV
60 70 80 90 100
SKTFGWYYLL AATLYIVFVV CIACSRFGSV KLGPEQSKPE FSLLSWAAML
110 120 130 140 150
FAAGIGIDLM FFSVAEPVTQ YMQPPEGAGQ TIEAARQAMV WTLFHYGLTG
160 170 180 190 200
WSMYALMGMA LGYFSYRYNL PLTIRSALYP IFGKRINGPI GHSVDIAAVI
210 220 230 240 250
GTIFGIATTL GIGVVQLNYG LSVLFDIPDS MAAKAALIAL SVIIATISVT
260 270 280 290 300
SGVDKGIRVL SELNVALALG LILFVLFMGD TSFLLNALVL NVGDYVNRFM
310 320 330 340 350
GMTLNSFAFD RPVEWMNNWT LFFWAWWVAW SPFVGLFLAR ISRGRTIRQF
360 370 380 390 400
VLGTLIIPFT FTLLWLSVFG NSALYEIIHG GAAFAEEAMV HPERGFYSLL
410 420 430 440 450
AQYPAFTFSA SVATITGLLF YVTSADSGAL VLGNFTSQLK DINSDAPGWL
460 470 480 490 500
RVFWSVAIGL LTLGMLMTNG ISALQNTTVI MGLPFSFVIF FVMAGLYKSL
510 520 530 540 550
KVEDYRRESA NRDTAPRPLG LQDRLSWKKR LSRLMNYPGT RYTKQMMETV
560 570 580 590 600
CYPAMEEVAQ ELRLRGAYVE LKSLPPEEGQ QLGHLDLLVH MGEEQNFVYQ
610 620 630 640 650
IWPQQYSVPG FTYRARSGKS TYYRLETFLL EGSQGNDLMD YSKEQVITDI
660 670
LDQYERHLNF IHLHREAPGH SVMFPDA
Length:677
Mass (Da):75,842
Last modified:November 8, 2005 - v1
Checksum:i76062FCE877D0A55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52905 Genomic DNA Translation: CAA37090.1
U73857 Genomic DNA Translation: AAB18040.1
U00096 Genomic DNA Translation: AAC73417.1
AP009048 Genomic DNA Translation: BAE76097.1
PIRiS15179
RefSeqiNP_414848.1, NC_000913.3
WP_000131044.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73417; AAC73417; b0314
BAE76097; BAE76097; BAE76097
GeneIDi945079
KEGGiecj:JW0306
eco:b0314
PATRICifig|1411691.4.peg.1963

Similar proteinsi

Entry informationi

Entry nameiBETT_ECOLI
AccessioniPrimary (citable) accession number: P0ABC9
Secondary accession number(s): P17447, Q2MCA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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