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Protein

High-affinity choline transport protein

Gene

betT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

High-affinity uptake of choline driven by a proton-motive force.

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in the pathway betaine biosynthesis via choline pathway, which is part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Stress response, Transport

Enzyme and pathway databases

BioCyciEcoCyc:BETT-MONOMER.
ECOL316407:JW0306-MONOMER.
MetaCyc:BETT-MONOMER.
UniPathwayiUPA00529.

Protein family/group databases

TCDBi2.A.15.1.4. the betaine/carnitine/choline transporter (bcct) family.

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity choline transport protein
Gene namesi
Name:betT
Ordered Locus Names:b0314, JW0306
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10112. betT.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Transmembranei477 – 497HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002014841 – 677High-affinity choline transport proteinAdd BLAST677

Proteomic databases

PaxDbiP0ABC9.
PRIDEiP0ABC9.

Expressioni

Inductioni

By osmotic stress. Choline is required for full expression.

Interactioni

Protein-protein interaction databases

BioGridi4262802. 218 interactors.
STRINGi511145.b0314.

Structurei

3D structure databases

ProteinModelPortaliP0ABC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C94. Bacteria.
COG1292. LUCA.
HOGENOMiHOG000053241.
InParanoidiP0ABC9.
KOiK02168.
OMAiGWAMYAL.
PhylomeDBiP0ABC9.

Family and domain databases

InterProiIPR018093. BCCT_CS.
IPR000060. BCCT_transptr.
[Graphical view]
PfamiPF02028. BCCT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00842. bcct. 1 hit.
PROSITEiPS01303. BCCT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ABC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLSHSREK DKINPVVFYT SAGLILLFSL TTILFRDFSA LWIGRTLDWV
60 70 80 90 100
SKTFGWYYLL AATLYIVFVV CIACSRFGSV KLGPEQSKPE FSLLSWAAML
110 120 130 140 150
FAAGIGIDLM FFSVAEPVTQ YMQPPEGAGQ TIEAARQAMV WTLFHYGLTG
160 170 180 190 200
WSMYALMGMA LGYFSYRYNL PLTIRSALYP IFGKRINGPI GHSVDIAAVI
210 220 230 240 250
GTIFGIATTL GIGVVQLNYG LSVLFDIPDS MAAKAALIAL SVIIATISVT
260 270 280 290 300
SGVDKGIRVL SELNVALALG LILFVLFMGD TSFLLNALVL NVGDYVNRFM
310 320 330 340 350
GMTLNSFAFD RPVEWMNNWT LFFWAWWVAW SPFVGLFLAR ISRGRTIRQF
360 370 380 390 400
VLGTLIIPFT FTLLWLSVFG NSALYEIIHG GAAFAEEAMV HPERGFYSLL
410 420 430 440 450
AQYPAFTFSA SVATITGLLF YVTSADSGAL VLGNFTSQLK DINSDAPGWL
460 470 480 490 500
RVFWSVAIGL LTLGMLMTNG ISALQNTTVI MGLPFSFVIF FVMAGLYKSL
510 520 530 540 550
KVEDYRRESA NRDTAPRPLG LQDRLSWKKR LSRLMNYPGT RYTKQMMETV
560 570 580 590 600
CYPAMEEVAQ ELRLRGAYVE LKSLPPEEGQ QLGHLDLLVH MGEEQNFVYQ
610 620 630 640 650
IWPQQYSVPG FTYRARSGKS TYYRLETFLL EGSQGNDLMD YSKEQVITDI
660 670
LDQYERHLNF IHLHREAPGH SVMFPDA
Length:677
Mass (Da):75,842
Last modified:November 8, 2005 - v1
Checksum:i76062FCE877D0A55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52905 Genomic DNA. Translation: CAA37090.1.
U73857 Genomic DNA. Translation: AAB18040.1.
U00096 Genomic DNA. Translation: AAC73417.1.
AP009048 Genomic DNA. Translation: BAE76097.1.
PIRiS15179.
RefSeqiNP_414848.1. NC_000913.3.
WP_000131044.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73417; AAC73417; b0314.
BAE76097; BAE76097; BAE76097.
GeneIDi945079.
KEGGiecj:JW0306.
eco:b0314.
PATRICi32115757. VBIEscCol129921_0321.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52905 Genomic DNA. Translation: CAA37090.1.
U73857 Genomic DNA. Translation: AAB18040.1.
U00096 Genomic DNA. Translation: AAC73417.1.
AP009048 Genomic DNA. Translation: BAE76097.1.
PIRiS15179.
RefSeqiNP_414848.1. NC_000913.3.
WP_000131044.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ABC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262802. 218 interactors.
STRINGi511145.b0314.

Protein family/group databases

TCDBi2.A.15.1.4. the betaine/carnitine/choline transporter (bcct) family.

Proteomic databases

PaxDbiP0ABC9.
PRIDEiP0ABC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73417; AAC73417; b0314.
BAE76097; BAE76097; BAE76097.
GeneIDi945079.
KEGGiecj:JW0306.
eco:b0314.
PATRICi32115757. VBIEscCol129921_0321.

Organism-specific databases

EchoBASEiEB0110.
EcoGeneiEG10112. betT.

Phylogenomic databases

eggNOGiENOG4105C94. Bacteria.
COG1292. LUCA.
HOGENOMiHOG000053241.
InParanoidiP0ABC9.
KOiK02168.
OMAiGWAMYAL.
PhylomeDBiP0ABC9.

Enzyme and pathway databases

UniPathwayiUPA00529.
BioCyciEcoCyc:BETT-MONOMER.
ECOL316407:JW0306-MONOMER.
MetaCyc:BETT-MONOMER.

Miscellaneous databases

PROiP0ABC9.

Family and domain databases

InterProiIPR018093. BCCT_CS.
IPR000060. BCCT_transptr.
[Graphical view]
PfamiPF02028. BCCT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00842. bcct. 1 hit.
PROSITEiPS01303. BCCT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBETT_ECOLI
AccessioniPrimary (citable) accession number: P0ABC9
Secondary accession number(s): P17447, Q2MCA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.