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Protein

ATP synthase gamma chain

Gene

atpG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF0 complex.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-HAMAP
  • proton-transporting ATPase activity, rotational mechanism Source: EcoCyc
  • proton-transporting ATP synthase activity, rotational mechanism Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:ATPG-MONOMER.
ECOL316407:JW3711-MONOMER.
MetaCyc:ATPG-MONOMER.

Protein family/group databases

TCDBi3.A.2.1.1. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase gamma chain
Alternative name(s):
ATP synthase F1 sector gamma subunit
F-ATPase gamma subunit
Gene namesi
Name:atpG
Synonyms:papC, uncG
Ordered Locus Names:b3733, JW3711
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10104. atpG.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
  • proton-transporting ATP synthase complex, catalytic core F(1) Source: EcoliWiki
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, CF(1), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287ATP synthase gamma chainPRO_0000073282Add
BLAST

Proteomic databases

EPDiP0ABA6.
PaxDbiP0ABA6.
PRIDEiP0ABA6.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
atpCP0A6E64EBI-544306,EBI-544362

Protein-protein interaction databases

DIPiDIP-35938N.
IntActiP0ABA6. 15 interactions.
STRINGi511145.b3733.

Structurei

Secondary structure

1
287
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi20 – 5738Combined sources
Turni61 – 633Combined sources
Helixi66 – 683Combined sources
Beta strandi74 – 818Combined sources
Beta strandi84 – 863Combined sources
Helixi91 – 10818Combined sources
Beta strandi112 – 1198Combined sources
Helixi120 – 12910Combined sources
Beta strandi133 – 1375Combined sources
Helixi147 – 16115Combined sources
Beta strandi168 – 17710Combined sources
Beta strandi180 – 19011Combined sources
Turni196 – 1983Combined sources
Beta strandi207 – 2104Combined sources
Helixi212 – 24736Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D8SX-ray4.40G1-287[»]
1FS0X-ray2.10G19-248[»]
3OAAX-ray3.26G/O/W/e2-287[»]
ProteinModelPortaliP0ABA6.
SMRiP0ABA6. Positions 2-285.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ABA6.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase gamma chain family.Curated

Phylogenomic databases

eggNOGiENOG4105J80. Bacteria.
COG0224. LUCA.
HOGENOMiHOG000215912.
InParanoidiP0ABA6.
KOiK02115.
OMAiDRGMCGG.
PhylomeDBiP0ABA6.

Family and domain databases

CDDicd12151. F1-ATPase_gamma. 1 hit.
HAMAPiMF_00815. ATP_synth_gamma_bact. 1 hit.
InterProiIPR000131. ATPase_F1-cplx_gsu.
IPR023632. ATPase_F1_gsu_CS.
[Graphical view]
PANTHERiPTHR11693. PTHR11693. 1 hit.
PfamiPF00231. ATP-synt. 1 hit.
[Graphical view]
PRINTSiPR00126. ATPASEGAMMA.
SUPFAMiSSF52943. SSF52943. 1 hit.
TIGRFAMsiTIGR01146. ATPsyn_F1gamma. 1 hit.
PROSITEiPS00153. ATPASE_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ABA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAKEIRSK IASVQNTQKI TKAMEMVAAS KMRKSQDRMA ASRPYAETMR
60 70 80 90 100
KVIGHLAHGN LEYKHPYLED RDVKRVGYLV VSTDRGLCGG LNINLFKKLL
110 120 130 140 150
AEMKTWTDKG VQCDLAMIGS KGVSFFNSVG GNVVAQVTGM GDNPSLSELI
160 170 180 190 200
GPVKVMLQAY DEGRLDKLYI VSNKFINTMS QVPTISQLLP LPASDDDDLK
210 220 230 240 250
HKSWDYLYEP DPKALLDTLL RRYVESQVYQ GVVENLASEQ AARMVAMKAA
260 270 280
TDNGGSLIKE LQLVYNKARQ ASITQELTEI VSGAAAV
Length:287
Mass (Da):31,577
Last modified:July 21, 1986 - v1
Checksum:i2417A4B8FBDB8EF8
GO

Sequence cautioni

The sequence CAA23597 differs from that shown.Sequencing errors.Curated
The sequence CAA23597 differs from that shown. Reason: Frameshift at several positions. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01631 Genomic DNA. Translation: CAA25781.1.
V00267 Genomic DNA. Translation: CAA23526.1.
J01594 Genomic DNA. Translation: AAA24736.1. Frameshift.
V00312 Genomic DNA. Translation: CAA23597.1. Sequence problems.
M25464 Genomic DNA. Translation: AAA83874.1.
L10328 Genomic DNA. Translation: AAA62085.1.
U00096 Genomic DNA. Translation: AAC76756.1.
AP009048 Genomic DNA. Translation: BAE77555.1.
M34095 Genomic DNA. Translation: AAA24742.1.
PIRiA01038. PWECG.
RefSeqiNP_418189.1. NC_000913.3.
WP_000896498.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76756; AAC76756; b3733.
BAE77555; BAE77555; BAE77555.
GeneIDi948243.
KEGGiecj:JW3711.
eco:b3733.
PATRICi32122963. VBIEscCol129921_3857.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01631 Genomic DNA. Translation: CAA25781.1.
V00267 Genomic DNA. Translation: CAA23526.1.
J01594 Genomic DNA. Translation: AAA24736.1. Frameshift.
V00312 Genomic DNA. Translation: CAA23597.1. Sequence problems.
M25464 Genomic DNA. Translation: AAA83874.1.
L10328 Genomic DNA. Translation: AAA62085.1.
U00096 Genomic DNA. Translation: AAC76756.1.
AP009048 Genomic DNA. Translation: BAE77555.1.
M34095 Genomic DNA. Translation: AAA24742.1.
PIRiA01038. PWECG.
RefSeqiNP_418189.1. NC_000913.3.
WP_000896498.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D8SX-ray4.40G1-287[»]
1FS0X-ray2.10G19-248[»]
3OAAX-ray3.26G/O/W/e2-287[»]
ProteinModelPortaliP0ABA6.
SMRiP0ABA6. Positions 2-285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-35938N.
IntActiP0ABA6. 15 interactions.
STRINGi511145.b3733.

Protein family/group databases

TCDBi3.A.2.1.1. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Proteomic databases

EPDiP0ABA6.
PaxDbiP0ABA6.
PRIDEiP0ABA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76756; AAC76756; b3733.
BAE77555; BAE77555; BAE77555.
GeneIDi948243.
KEGGiecj:JW3711.
eco:b3733.
PATRICi32122963. VBIEscCol129921_3857.

Organism-specific databases

EchoBASEiEB0102.
EcoGeneiEG10104. atpG.

Phylogenomic databases

eggNOGiENOG4105J80. Bacteria.
COG0224. LUCA.
HOGENOMiHOG000215912.
InParanoidiP0ABA6.
KOiK02115.
OMAiDRGMCGG.
PhylomeDBiP0ABA6.

Enzyme and pathway databases

BioCyciEcoCyc:ATPG-MONOMER.
ECOL316407:JW3711-MONOMER.
MetaCyc:ATPG-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0ABA6.
PROiP0ABA6.

Family and domain databases

CDDicd12151. F1-ATPase_gamma. 1 hit.
HAMAPiMF_00815. ATP_synth_gamma_bact. 1 hit.
InterProiIPR000131. ATPase_F1-cplx_gsu.
IPR023632. ATPase_F1_gsu_CS.
[Graphical view]
PANTHERiPTHR11693. PTHR11693. 1 hit.
PfamiPF00231. ATP-synt. 1 hit.
[Graphical view]
PRINTSiPR00126. ATPASEGAMMA.
SUPFAMiSSF52943. SSF52943. 1 hit.
TIGRFAMsiTIGR01146. ATPsyn_F1gamma. 1 hit.
PROSITEiPS00153. ATPASE_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATPG_ECOLI
AccessioniPrimary (citable) accession number: P0ABA6
Secondary accession number(s): P00837, P00838, Q2M851
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.