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P0ABA4

- ATPD_ECOLI

UniProt

P0ABA4 - ATPD_ECOLI

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Protein
ATP synthase subunit delta
Gene
atpH, papE, uncH, b3735, JW3713
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

F1F0 ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F1 containing the extramembraneous catalytic core and F0 containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation.UniRule annotation
This protein is part of the stalk that links CF0 to CF1. It either transmits conformational changes from CF0 to CF1 or is implicated in proton conduction.UniRule annotation

GO - Molecular functioni

  1. proton-transporting ATP synthase activity, rotational mechanism Source: EcoCyc
  2. proton-transporting ATPase activity, rotational mechanism Source: EcoCyc

GO - Biological processi

  1. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:ATPH-MONOMER.
ECOL316407:JW3713-MONOMER.
MetaCyc:ATPH-MONOMER.

Protein family/group databases

TCDBi3.A.2.1.1. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit delta
Alternative name(s):
ATP synthase F(1) sector subunit delta
F-type ATPase subunit delta
Short name:
F-ATPase subunit delta
Gene namesi
Name:atpH
Synonyms:papE, uncH
Ordered Locus Names:b3735, JW3713
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG10105. atpH.

Subcellular locationi

Cell inner membrane; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
  2. proton-transporting ATP synthase complex, catalytic core F(1) Source: EcoliWiki
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, CF(1), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177ATP synthase subunit deltaUniRule annotation
PRO_0000193462Add
BLAST

Proteomic databases

PaxDbiP0ABA4.
PRIDEiP0ABA4.

Expressioni

Gene expression databases

GenevestigatoriP0ABA4.

Interactioni

Subunit structurei

F-type ATPases have 2 components, F1 - the catalytic core - and F0 - the membrane proton channel. F1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. F0 has three main subunits: a1, b2 and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F1 is attached to F0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.1 Publication

Protein-protein interaction databases

DIPiDIP-47921N.
IntActiP0ABA4. 13 interactions.
STRINGi511145.b3735.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 2117
Helixi25 – 3915
Helixi42 – 487
Helixi54 – 6512
Helixi71 – 8212
Helixi86 – 883
Helixi89 – 10517

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ABVNMR-A2-135[»]
2A7UNMR-B2-135[»]
ProteinModelPortaliP0ABA4.
SMRiP0ABA4. Positions 2-135.

Miscellaneous databases

EvolutionaryTraceiP0ABA4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0712.
HOGENOMiHOG000075824.
KOiK02113.
OMAiCGEQINE.
OrthoDBiEOG6DNTDK.
PhylomeDBiP0ABA4.

Family and domain databases

Gene3Di1.10.520.20. 1 hit.
HAMAPiMF_01416. ATP_synth_delta_bact.
InterProiIPR020781. ATPase_OSCP/d_CS.
IPR026015. ATPase_OSCP/delta_N.
IPR000711. ATPase_OSCP/dsu.
[Graphical view]
PANTHERiPTHR11910. PTHR11910. 1 hit.
PfamiPF00213. OSCP. 1 hit.
[Graphical view]
PRINTSiPR00125. ATPASEDELTA.
SUPFAMiSSF47928. SSF47928. 1 hit.
TIGRFAMsiTIGR01145. ATP_synt_delta. 1 hit.
PROSITEiPS00389. ATPASE_DELTA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ABA4-1 [UniParc]FASTAAdd to Basket

« Hide

MSEFITVARP YAKAAFDFAV EHQSVERWQD MLAFAAEVTK NEQMAELLSG    50
ALAPETLAES FIAVCGEQLD ENGQNLIRVM AENGRLNALP DVLEQFIHLR 100
AVSEATAEVD VISAAALSEQ QLAKISAAME KRLSRKVKLN CKIDKSVMAG 150
VIIRAGDMVI DGSVRGRLER LADVLQS 177
Length:177
Mass (Da):19,332
Last modified:July 21, 1986 - v1
Checksum:i6AFD9552A79C81A5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821E → D in AAA20044. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J01594 Genomic DNA. Translation: AAA24734.1.
M12212 Unassigned DNA. Translation: AAA20044.1.
X01631 Genomic DNA. Translation: CAA25779.1.
V00266 Genomic DNA. Translation: CAA23524.1.
V00264 Genomic DNA. Translation: CAA23517.1.
M25464 Genomic DNA. Translation: AAA83872.1.
L10328 Genomic DNA. Translation: AAA62087.1.
U00096 Genomic DNA. Translation: AAC76758.1.
AP009048 Genomic DNA. Translation: BAE77553.1.
PIRiA93732. PWECD.
RefSeqiNP_418191.1. NC_000913.3.
YP_491694.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC76758; AAC76758; b3735.
BAE77553; BAE77553; BAE77553.
GeneIDi12933117.
948254.
KEGGiecj:Y75_p3433.
eco:b3735.
PATRICi32122967. VBIEscCol129921_3859.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J01594 Genomic DNA. Translation: AAA24734.1 .
M12212 Unassigned DNA. Translation: AAA20044.1 .
X01631 Genomic DNA. Translation: CAA25779.1 .
V00266 Genomic DNA. Translation: CAA23524.1 .
V00264 Genomic DNA. Translation: CAA23517.1 .
M25464 Genomic DNA. Translation: AAA83872.1 .
L10328 Genomic DNA. Translation: AAA62087.1 .
U00096 Genomic DNA. Translation: AAC76758.1 .
AP009048 Genomic DNA. Translation: BAE77553.1 .
PIRi A93732. PWECD.
RefSeqi NP_418191.1. NC_000913.3.
YP_491694.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ABV NMR - A 2-135 [» ]
2A7U NMR - B 2-135 [» ]
ProteinModelPortali P0ABA4.
SMRi P0ABA4. Positions 2-135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-47921N.
IntActi P0ABA4. 13 interactions.
STRINGi 511145.b3735.

Protein family/group databases

TCDBi 3.A.2.1.1. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Proteomic databases

PaxDbi P0ABA4.
PRIDEi P0ABA4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC76758 ; AAC76758 ; b3735 .
BAE77553 ; BAE77553 ; BAE77553 .
GeneIDi 12933117.
948254.
KEGGi ecj:Y75_p3433.
eco:b3735.
PATRICi 32122967. VBIEscCol129921_3859.

Organism-specific databases

EchoBASEi EB0103.
EcoGenei EG10105. atpH.

Phylogenomic databases

eggNOGi COG0712.
HOGENOMi HOG000075824.
KOi K02113.
OMAi CGEQINE.
OrthoDBi EOG6DNTDK.
PhylomeDBi P0ABA4.

Enzyme and pathway databases

BioCyci EcoCyc:ATPH-MONOMER.
ECOL316407:JW3713-MONOMER.
MetaCyc:ATPH-MONOMER.

Miscellaneous databases

EvolutionaryTracei P0ABA4.
PROi P0ABA4.

Gene expression databases

Genevestigatori P0ABA4.

Family and domain databases

Gene3Di 1.10.520.20. 1 hit.
HAMAPi MF_01416. ATP_synth_delta_bact.
InterProi IPR020781. ATPase_OSCP/d_CS.
IPR026015. ATPase_OSCP/delta_N.
IPR000711. ATPase_OSCP/dsu.
[Graphical view ]
PANTHERi PTHR11910. PTHR11910. 1 hit.
Pfami PF00213. OSCP. 1 hit.
[Graphical view ]
PRINTSi PR00125. ATPASEDELTA.
SUPFAMi SSF47928. SSF47928. 1 hit.
TIGRFAMsi TIGR01145. ATP_synt_delta. 1 hit.
PROSITEi PS00389. ATPASE_DELTA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence around the Escherichia coli unc operon. Completion of the sequence of a 17 kilobase segment containing asnA, oriC, unc, glmS and phoS."
    Walker J.E., Gay N.J., Saraste M., Eberle A.N.
    Biochem. J. 224:799-815(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The atp operon: nucleotide sequence of the promoter and the genes for the membrane proteins, and the delta subunit of Escherichia coli ATP-synthase."
    Gay N.J., Walker J.E.
    Nucleic Acids Res. 9:3919-3926(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The nucleotide sequence of the atp genes coding for the F0 subunits a, b, c and the F1 subunit delta of the membrane bound ATP synthase of Escherichia coli."
    Nielsen J., Hansen F.G., Hoppe J., Friedl P., von Meyenburg K.
    Mol. Gen. Genet. 184:33-39(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Nucleotide sequence of the gene coding for the delta subunit of proton translocating ATPase of Escherichia coli."
    Mabuchi K., Kanazawa H., Kayano T., Futai M.
    Biochem. Biophys. Res. Commun. 102:172-179(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Structure and function of H+-ATPase: what we have learned from Escherichia coli H+-ATPase."
    Kanazawa H., Futai M.
    Ann. N. Y. Acad. Sci. 402:45-64(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication."
    Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.
    Genomics 16:551-561(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  8. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  9. Cited for: SUBUNIT, SUBCELLULAR LOCATION.
    Strain: BL21-DE3.
  10. "Solution structure of the N-terminal domain of the delta subunit of the E. coli ATPsynthase."
    Wilkens S., Dunn S.D., Chandler J., Dahlquist F.W., Capaldi R.A.
    Nat. Struct. Biol. 4:198-201(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-135.

Entry informationi

Entry nameiATPD_ECOLI
AccessioniPrimary (citable) accession number: P0ABA4
Secondary accession number(s): P00831, Q2M853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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