P0AB96 (ARSC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arsenate reductase
EC=1.20.4.1

Alternative name(s):
Arsenical pump modifier

Gene names

Name:	arsC
Synonyms:	arsG
Ordered Locus Names:	b3503, JW3470

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	141 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance By similarity.
Catalytic activity	Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O.
Sequence similarities	Belongs to the ArsC family.

Ontologies

Keywords
Biological process	Arsenical resistance
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to arsenic-containing substance Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arsenate reductase (glutaredoxin) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 141	141	Arsenate reductase		PRO_0000162536

Sequences

	Sequence		Length	Mass (Da)
	P0AB96 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 5490FBBD14B24D3C	FASTA	141	15,853
	10 20 30 40 50 60 MSNITIYHNP ACGTSRNTLE MIRNSGTEPT IIHYLETPPT RDELVKLIAD MGISVRALLR 70 80 90 100 110 120 KNVEPYEELG LAEDKFTDDR LIDFMLQHPI LINRPIVVTP LGTRLCRPSE VVLEILPDAQ 130 140 KGAFSKEDGE KVVDEAGKRL K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An Escherichia coli chromosomal ars operon homolog is functional in arsenic detoxification and is conserved in Gram-negative bacteria." Diorio C., Cai J., Marmor J., Shinder R., Dubow M.S. J. Bacteriol. 177:2050-2056(1995) [PubMed: 7721697] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes." Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R. Nucleic Acids Res. 22:2576-2586(1994) [PubMed: 8041620] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X80057 Genomic DNA. Translation: CAA56363.1. U00039 Genomic DNA. Translation: AAB18479.1. U00096 Genomic DNA. Translation: AAC76528.1. AP009048 Genomic DNA. Translation: BAE77791.1.
PIR	C56269.
RefSeq	NP_417960.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P0AB96.
SMR	P0AB96. Positions 3-140.
ModBase	Search...
Protein-protein interaction databases
IntAct	P0AB96. 2 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000003563; EBESCP00000003563; EBESCG00000002910. EBESCT00000014654; EBESCP00000013945; EBESCG00000013715.
GeneID	948018.
GenomeReviews	Gene locus JW3470 in contig AP009048_GR. Gene locus b3503 in contig U00096_GR.
KEGG	ecj:JW3470. eco:b3503.
PATRIC	32122460. VBIEscCol129921_3607.
Organism-specific databases
EchoBASE	EB2149.
EcoGene	EG12237. arsC.
Phylogenomic databases
eggNOG	COG1393.
GeneTree	EBGT00050000009450.
HOGENOM	HBG734370.
OMA	IRNSGNE.
PhylomeDB	P0AB96.
ProtClustDB	PRK10026.
Enzyme and pathway databases
BioCyc	EcoCyc:EG12237-MONOMER. MetaCyc:EG12237-MONOMER.
Gene expression databases
Genevestigator	P0AB96.
Family and domain databases
InterPro	IPR006659. Arsenate_reductase. IPR006660. Arsenate_reductase-like. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K00537.
Pfam	PF03960. ArsC. 1 hit. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR00014. ArsC. 1 hit.
PROSITE	PS51353. ARSC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARSC_ECOLI

Accession

Primary (citable) accession number: P0AB96
Secondary accession number(s): P37311, Q2M7G5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program