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Protein

Arsenate reductase

Gene

arsC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance (By similarity).By similarity

Catalytic activityi

Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O.

GO - Molecular functioni

  • arsenate reductase (glutaredoxin) activity Source: EcoCyc

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • response to arsenic-containing substance Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Arsenical resistance

Enzyme and pathway databases

BioCyciEcoCyc:EG12237-MONOMER.
ECOL316407:JW3470-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenate reductase (EC:1.20.4.1)
Alternative name(s):
Arsenical pump modifier
Gene namesi
Name:arsC
Synonyms:arsG
Ordered Locus Names:b3503, JW3470
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12237. arsC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001625361 – 141Arsenate reductaseAdd BLAST141

Proteomic databases

PaxDbiP0AB96.
PRIDEiP0AB96.

Interactioni

Protein-protein interaction databases

BioGridi4261140. 6 interactors.
IntActiP0AB96. 2 interactors.
STRINGi511145.b3503.

Structurei

3D structure databases

ProteinModelPortaliP0AB96.
SMRiP0AB96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ArsC family.Curated

Phylogenomic databases

eggNOGiENOG4105K89. Bacteria.
COG1393. LUCA.
HOGENOMiHOG000059717.
InParanoidiP0AB96.
KOiK00537.
OMAiHYLENPP.
PhylomeDBiP0AB96.

Family and domain databases

CDDicd03034. ArsC_ArsC. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR006659. Arsenate_reductase.
IPR006660. Arsenate_reductase-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF03960. ArsC. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00014. arsC. 1 hit.
PROSITEiPS51353. ARSC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AB96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNITIYHNP ACGTSRNTLE MIRNSGTEPT IIHYLETPPT RDELVKLIAD
60 70 80 90 100
MGISVRALLR KNVEPYEELG LAEDKFTDDR LIDFMLQHPI LINRPIVVTP
110 120 130 140
LGTRLCRPSE VVLEILPDAQ KGAFSKEDGE KVVDEAGKRL K
Length:141
Mass (Da):15,853
Last modified:November 8, 2005 - v1
Checksum:i5490FBBD14B24D3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80057 Genomic DNA. Translation: CAA56363.1.
U00039 Genomic DNA. Translation: AAB18479.1.
U00096 Genomic DNA. Translation: AAC76528.1.
AP009048 Genomic DNA. Translation: BAE77791.1.
PIRiC56269.
RefSeqiNP_417960.1. NC_000913.3.
WP_000065769.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76528; AAC76528; b3503.
BAE77791; BAE77791; BAE77791.
GeneIDi948018.
KEGGiecj:JW3470.
eco:b3503.
PATRICi32122460. VBIEscCol129921_3607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80057 Genomic DNA. Translation: CAA56363.1.
U00039 Genomic DNA. Translation: AAB18479.1.
U00096 Genomic DNA. Translation: AAC76528.1.
AP009048 Genomic DNA. Translation: BAE77791.1.
PIRiC56269.
RefSeqiNP_417960.1. NC_000913.3.
WP_000065769.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AB96.
SMRiP0AB96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261140. 6 interactors.
IntActiP0AB96. 2 interactors.
STRINGi511145.b3503.

Proteomic databases

PaxDbiP0AB96.
PRIDEiP0AB96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76528; AAC76528; b3503.
BAE77791; BAE77791; BAE77791.
GeneIDi948018.
KEGGiecj:JW3470.
eco:b3503.
PATRICi32122460. VBIEscCol129921_3607.

Organism-specific databases

EchoBASEiEB2149.
EcoGeneiEG12237. arsC.

Phylogenomic databases

eggNOGiENOG4105K89. Bacteria.
COG1393. LUCA.
HOGENOMiHOG000059717.
InParanoidiP0AB96.
KOiK00537.
OMAiHYLENPP.
PhylomeDBiP0AB96.

Enzyme and pathway databases

BioCyciEcoCyc:EG12237-MONOMER.
ECOL316407:JW3470-MONOMER.

Miscellaneous databases

PROiP0AB96.

Family and domain databases

CDDicd03034. ArsC_ArsC. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR006659. Arsenate_reductase.
IPR006660. Arsenate_reductase-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF03960. ArsC. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00014. arsC. 1 hit.
PROSITEiPS51353. ARSC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARSC_ECOLI
AccessioniPrimary (citable) accession number: P0AB96
Secondary accession number(s): P37311, Q2M7G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.