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Protein

Arsenate reductase

Gene

arsC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance (By similarity).By similarity

Catalytic activityi

Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O.

GO - Molecular functioni

  • arsenate reductase (glutaredoxin) activity Source: EcoCyc

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • response to arsenic-containing substance Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Arsenical resistance

Enzyme and pathway databases

BioCyciEcoCyc:EG12237-MONOMER.
ECOL316407:JW3470-MONOMER.
MetaCyc:EG12237-MONOMER.
RETL1328306-WGS:GSTH-2558-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenate reductase (EC:1.20.4.1)
Alternative name(s):
Arsenical pump modifier
Gene namesi
Name:arsC
Synonyms:arsG
Ordered Locus Names:b3503, JW3470
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12237. arsC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141141Arsenate reductasePRO_0000162536Add
BLAST

Proteomic databases

PaxDbiP0AB96.
PRIDEiP0AB96.

Interactioni

Protein-protein interaction databases

BioGridi4261140. 6 interactions.
IntActiP0AB96. 2 interactions.
STRINGi511145.b3503.

Structurei

3D structure databases

ProteinModelPortaliP0AB96.
SMRiP0AB96. Positions 3-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ArsC family.Curated

Phylogenomic databases

eggNOGiENOG4105K89. Bacteria.
COG1393. LUCA.
HOGENOMiHOG000059717.
InParanoidiP0AB96.
KOiK00537.
OMAiHYLENPP.
OrthoDBiEOG6PP9QC.
PhylomeDBiP0AB96.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006659. Arsenate_reductase.
IPR006660. Arsenate_reductase-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF03960. ArsC. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00014. arsC. 1 hit.
PROSITEiPS51353. ARSC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AB96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNITIYHNP ACGTSRNTLE MIRNSGTEPT IIHYLETPPT RDELVKLIAD
60 70 80 90 100
MGISVRALLR KNVEPYEELG LAEDKFTDDR LIDFMLQHPI LINRPIVVTP
110 120 130 140
LGTRLCRPSE VVLEILPDAQ KGAFSKEDGE KVVDEAGKRL K
Length:141
Mass (Da):15,853
Last modified:November 8, 2005 - v1
Checksum:i5490FBBD14B24D3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80057 Genomic DNA. Translation: CAA56363.1.
U00039 Genomic DNA. Translation: AAB18479.1.
U00096 Genomic DNA. Translation: AAC76528.1.
AP009048 Genomic DNA. Translation: BAE77791.1.
PIRiC56269.
RefSeqiNP_417960.1. NC_000913.3.
WP_000065769.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76528; AAC76528; b3503.
BAE77791; BAE77791; BAE77791.
GeneIDi948018.
KEGGiecj:JW3470.
eco:b3503.
PATRICi32122460. VBIEscCol129921_3607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80057 Genomic DNA. Translation: CAA56363.1.
U00039 Genomic DNA. Translation: AAB18479.1.
U00096 Genomic DNA. Translation: AAC76528.1.
AP009048 Genomic DNA. Translation: BAE77791.1.
PIRiC56269.
RefSeqiNP_417960.1. NC_000913.3.
WP_000065769.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AB96.
SMRiP0AB96. Positions 3-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261140. 6 interactions.
IntActiP0AB96. 2 interactions.
STRINGi511145.b3503.

Proteomic databases

PaxDbiP0AB96.
PRIDEiP0AB96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76528; AAC76528; b3503.
BAE77791; BAE77791; BAE77791.
GeneIDi948018.
KEGGiecj:JW3470.
eco:b3503.
PATRICi32122460. VBIEscCol129921_3607.

Organism-specific databases

EchoBASEiEB2149.
EcoGeneiEG12237. arsC.

Phylogenomic databases

eggNOGiENOG4105K89. Bacteria.
COG1393. LUCA.
HOGENOMiHOG000059717.
InParanoidiP0AB96.
KOiK00537.
OMAiHYLENPP.
OrthoDBiEOG6PP9QC.
PhylomeDBiP0AB96.

Enzyme and pathway databases

BioCyciEcoCyc:EG12237-MONOMER.
ECOL316407:JW3470-MONOMER.
MetaCyc:EG12237-MONOMER.
RETL1328306-WGS:GSTH-2558-MONOMER.

Miscellaneous databases

PROiP0AB96.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006659. Arsenate_reductase.
IPR006660. Arsenate_reductase-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF03960. ArsC. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00014. arsC. 1 hit.
PROSITEiPS51353. ARSC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An Escherichia coli chromosomal ars operon homolog is functional in arsenic detoxification and is conserved in Gram-negative bacteria."
    Diorio C., Cai J., Marmor J., Shinder R., Dubow M.S.
    J. Bacteriol. 177:2050-2056(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes."
    Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.
    Nucleic Acids Res. 22:2576-2586(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiARSC_ECOLI
AccessioniPrimary (citable) accession number: P0AB96
Secondary accession number(s): P37311, Q2M7G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: January 20, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.