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P0AB88

- FUCA_SHIFL

UniProt

P0AB88 - FUCA_SHIFL

Protein

L-fuculose phosphate aldolase

Gene

fucA

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde.UniRule annotation

    Catalytic activityi

    L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei73 – 731Proton acceptorUniRule annotation
    Metal bindingi73 – 731ZincUniRule annotation
    Metal bindingi92 – 921ZincUniRule annotation
    Metal bindingi94 – 941ZincUniRule annotation
    Active sitei113 – 1131Proton donorUniRule annotation
    Metal bindingi155 – 1551ZincUniRule annotation

    GO - Molecular functioni

    1. L-fuculose-phosphate aldolase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fucose catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Carbohydrate metabolism, Fucose metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00563; UER00626.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-fuculose phosphate aldolaseUniRule annotation (EC:4.1.2.17UniRule annotation)
    Alternative name(s):
    L-fuculose-1-phosphate aldolaseUniRule annotation
    Gene namesi
    Name:fucAUniRule annotation
    Ordered Locus Names:SF2814, S3009
    OrganismiShigella flexneri
    Taxonomic identifieri623 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 215215L-fuculose phosphate aldolasePRO_0000162929Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi198214.SF2814.

    Structurei

    3D structure databases

    ProteinModelPortaliP0AB88.
    SMRiP0AB88. Positions 1-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldolase class II family. AraD/FucA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0235.
    HOGENOMiHOG000218184.
    KOiK01628.
    OMAiYATFGTH.
    OrthoDBiEOG6HQSSQ.

    Family and domain databases

    Gene3Di3.40.225.10. 1 hit.
    HAMAPiMF_00987. FucA.
    InterProiIPR001303. Aldolase_II/adducin_N.
    IPR004782. FucA.
    [Graphical view]
    PfamiPF00596. Aldolase_II. 1 hit.
    [Graphical view]
    SMARTiSM01007. Aldolase_II. 1 hit.
    [Graphical view]
    SUPFAMiSSF53639. SSF53639. 1 hit.
    TIGRFAMsiTIGR01086. fucA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0AB88-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERNKLARQI IDTCLEMTRL GLNQGTAGNV SVRYQDGMLI TPTGIPYEKL    50
    TESHIVFIDG NGKHEEGKLP SSEWRFHMAA YQSRPDANAV VHNHAVHCTA 100
    VSILNRSIPA IHYMIAAAGG NSIPCAPYAT FGTRELSEHV ALALKNRKAT 150
    LLQHHGLIAC EVNLEKALWL AHEVEVLAQL YLTTLAITDP VPVLSDEEIA 200
    VVLEKFKTYG LRIEE 215
    Length:215
    Mass (Da):23,775
    Last modified:November 8, 2005 - v1
    Checksum:iBA9897E13ABE4A22
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN44302.1.
    AE014073 Genomic DNA. Translation: AAP18127.1.
    RefSeqiNP_708595.1. NC_004337.2.
    NP_838317.1. NC_004741.1.

    Genome annotation databases

    EnsemblBacteriaiAAN44302; AAN44302; SF2814.
    AAP18127; AAP18127; S3009.
    GeneIDi1025774.
    1079274.
    KEGGisfl:SF2814.
    sfx:S3009.
    PATRICi18707695. VBIShiFle31049_3302.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN44302.1 .
    AE014073 Genomic DNA. Translation: AAP18127.1 .
    RefSeqi NP_708595.1. NC_004337.2.
    NP_838317.1. NC_004741.1.

    3D structure databases

    ProteinModelPortali P0AB88.
    SMRi P0AB88. Positions 1-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198214.SF2814.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN44302 ; AAN44302 ; SF2814 .
    AAP18127 ; AAP18127 ; S3009 .
    GeneIDi 1025774.
    1079274.
    KEGGi sfl:SF2814.
    sfx:S3009.
    PATRICi 18707695. VBIShiFle31049_3302.

    Phylogenomic databases

    eggNOGi COG0235.
    HOGENOMi HOG000218184.
    KOi K01628.
    OMAi YATFGTH.
    OrthoDBi EOG6HQSSQ.

    Enzyme and pathway databases

    UniPathwayi UPA00563 ; UER00626 .

    Family and domain databases

    Gene3Di 3.40.225.10. 1 hit.
    HAMAPi MF_00987. FucA.
    InterProi IPR001303. Aldolase_II/adducin_N.
    IPR004782. FucA.
    [Graphical view ]
    Pfami PF00596. Aldolase_II. 1 hit.
    [Graphical view ]
    SMARTi SM01007. Aldolase_II. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53639. SSF53639. 1 hit.
    TIGRFAMsi TIGR01086. fucA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
      Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
      , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
      Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 301 / Serotype 2a.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700930 / 2457T / Serotype 2a.

    Entry informationi

    Entry nameiFUCA_SHIFL
    AccessioniPrimary (citable) accession number: P0AB88
    Secondary accession number(s): P11550
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3