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Protein

Iron uptake system component EfeO

Gene

efeO

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in Fe2+ uptake. Could be an iron-binding and/or electron-transfer component.1 Publication

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoCyc
  • response to antibiotic Source: EcoCyc
  • response to zinc ion Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G6527-MONOMER.
ECOL316407:JW1003-MONOMER.

Protein family/group databases

TCDBi2.A.108.2.3. the iron/lead transporter (ilt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Iron uptake system component EfeO
Gene namesi
Name:efeO
Synonyms:ycdO
Ordered Locus Names:b1018, JW1003
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13861. efeO.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626CuratedAdd
BLAST
Chaini27 – 375349Iron uptake system component EfeOPRO_0000168804Add
BLAST

Proteomic databases

EPDiP0AB24.
PaxDbiP0AB24.
PRIDEiP0AB24.

Expressioni

Inductioni

Repressed by Fur in the presence of iron. Repressed at high pH by the two-component regulatory system CpxA/CpxR.2 Publications

Interactioni

Subunit structurei

Monomer. Part of a ferrous iron transporter composed of EfeU, EfeO and EfeB. However, this EfeUOB tripartite iron transporter is defective in E.coli strain K12 due to a frameshift mutation in EfeU.2 Publications

Protein-protein interaction databases

BioGridi4260053. 15 interactions.
IntActiP0AB24. 7 interactions.
STRINGi511145.b1018.

Structurei

3D structure databases

ProteinModelPortaliP0AB24.
SMRiP0AB24. Positions 128-375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Contains an N-terminal Cup-like domain and a C-terminal peptidase domain, separated by a flexible linker. Structural modeling identifies 2 potential metal-binding sites in the Cup-like domain, with site I binding Cu(2+) and site II favoring Fe(3+). The peptidase domain may also contain an iron-binding site.1 Publication

Sequence similaritiesi

Belongs to the EfeM/EfeO family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410650H. Bacteria.
COG2822. LUCA.
HOGENOMiHOG000236929.
InParanoidiP0AB24.
KOiK07224.
OMAiPQLQKEN.
PhylomeDBiP0AB24.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR008972. Cupredoxin.
IPR028096. EfeO_Cupredoxin.
[Graphical view]
PfamiPF13473. Cupredoxin_1. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AB24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTINFRRNAL QLSVAALFSS AFMANAADVP QVKVTVTDKQ CEPMTITVNA
60 70 80 90 100
GKTQFIIQNH SQKALEWEIL KGVMVVEERE NIAPGFSQKM TANLQPGEYD
110 120 130 140 150
MTCGLLTNPK GKLIVKGEAT ADAAQSDALL SLGGAITAYK AYVMAETTQL
160 170 180 190 200
VTDTKAFTDA IKAGDIEKAK ALYAPTRQHY ERIEPIAELF SDLDGSIDAR
210 220 230 240 250
EDDYEQKAAD PKFTGFHRLE KALFGDNTTK GMDQYAEQLY TDVVDLQKRI
260 270 280 290 300
SELAFPPSKV VGGAAGLIEE VAASKISGEE DRYSHTDLWD FQANVEGSQK
310 320 330 340 350
IVDLLRPQLQ KANPELLAKV DANFKKVDTI LAKYRTKDGF ETYDKLTDAD
360 370
RNALKGPITA LAEDLAQLRG VLGLD
Length:375
Mass (Da):41,138
Last modified:October 11, 2005 - v1
Checksum:iA3CA2A106A58F09F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74103.1.
AP009048 Genomic DNA. Translation: BAA35795.2.
PIRiH64843.
RefSeqiNP_415537.1. NC_000913.3.
WP_000154398.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74103; AAC74103; b1018.
BAA35795; BAA35795; BAA35795.
GeneIDi945603.
KEGGiecj:JW1003.
eco:b1018.
PATRICi32117269. VBIEscCol129921_1058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74103.1.
AP009048 Genomic DNA. Translation: BAA35795.2.
PIRiH64843.
RefSeqiNP_415537.1. NC_000913.3.
WP_000154398.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AB24.
SMRiP0AB24. Positions 128-375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260053. 15 interactions.
IntActiP0AB24. 7 interactions.
STRINGi511145.b1018.

Protein family/group databases

TCDBi2.A.108.2.3. the iron/lead transporter (ilt) family.

Proteomic databases

EPDiP0AB24.
PaxDbiP0AB24.
PRIDEiP0AB24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74103; AAC74103; b1018.
BAA35795; BAA35795; BAA35795.
GeneIDi945603.
KEGGiecj:JW1003.
eco:b1018.
PATRICi32117269. VBIEscCol129921_1058.

Organism-specific databases

EchoBASEiEB3621.
EcoGeneiEG13861. efeO.

Phylogenomic databases

eggNOGiENOG410650H. Bacteria.
COG2822. LUCA.
HOGENOMiHOG000236929.
InParanoidiP0AB24.
KOiK07224.
OMAiPQLQKEN.
PhylomeDBiP0AB24.

Enzyme and pathway databases

BioCyciEcoCyc:G6527-MONOMER.
ECOL316407:JW1003-MONOMER.

Miscellaneous databases

PROiP0AB24.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR008972. Cupredoxin.
IPR028096. EfeO_Cupredoxin.
[Graphical view]
PfamiPF13473. Cupredoxin_1. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEFEO_ECOLI
AccessioniPrimary (citable) accession number: P0AB24
Secondary accession number(s): P75902, Q9R2S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.