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Protein

Envelope biogenesis factor ElyC

Gene

elyC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Plays a critical role in the metabolism of the essential lipid carrier used for cell wall synthesis.1 Publication

GO - Biological processi

  • cell wall organization Source: UniProtKB-KW
  • Gram-negative-bacterium-type cell wall biogenesis Source: EcoCyc
  • peptidoglycan metabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciEcoCyc:EG12166-MONOMER.
ECOL316407:JW0903-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope biogenesis factor ElyC
Alternative name(s):
Elevated frequency of lysis
Gene namesi
Name:elyC
Synonyms:ycbC
Ordered Locus Names:b0920, JW0903
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12166. elyC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Deletion causes a severe growth defect at low temperature and an elevated frequency of cell lysis resulting from impaired metabolism of the essential lipid precursor required for peptidoglycan synthesis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Envelope biogenesis factor ElyCPRO_0000168768Add
BLAST

Proteomic databases

EPDiP0AB01.
PaxDbiP0AB01.
PRIDEiP0AB01.

Interactioni

Protein-protein interaction databases

BioGridi4263426. 296 interactions.
IntActiP0AB01. 3 interactions.
STRINGi511145.b0920.

Structurei

3D structure databases

ProteinModelPortaliP0AB01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107S90. Bacteria.
COG1434. LUCA.
HOGENOMiHOG000259549.
InParanoidiP0AB01.
OMAiLWFTRWQ.
OrthoDBiEOG6SBT3M.
PhylomeDBiP0AB01.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR003848. DUF218.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02698. DUF218. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AB01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFTLKKVIG NMLLPLPLML LIIGAGLALL WFSRFQKTGK IFISIGWLAL
60 70 80 90 100
LLLSLQPVAD RLLRPIESTY PTWNNSQKVD YIVVLGGGYT WNPQWAPSSN
110 120 130 140 150
LINNSLPRLN EGIRLWRENP GSKLIFTGGV AKTNTVSTAE VGARVAQSLG
160 170 180 190 200
VPREQIITLD LPKDTEEEAA AVKQAIGDAP FLLVTSASHL PRAMIFFQQE
210 220 230 240 250
GLNPLPAPAN QLAIDSPLNP WERAIPSPVW LMHSDRVGYE TLGRIWQWLK

GSSGEPRQE
Length:259
Mass (Da):28,666
Last modified:October 11, 2005 - v1
Checksum:i7EAE14C696DAA0C9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891Y → N in D26440 (PubMed:7513784).Curated
Sequence conflicti150 – 17021GVPRE…EEEAA → ACRASKLSPWICQKIPKKKL Q in D26440 (PubMed:7513784).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74006.1.
AP009048 Genomic DNA. Translation: BAA35666.1.
D26440 Genomic DNA. No translation available.
PIRiG64831.
RefSeqiNP_415440.1. NC_000913.3.
WP_000899600.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74006; AAC74006; b0920.
BAA35666; BAA35666; BAA35666.
GeneIDi945546.
KEGGiecj:JW0903.
eco:b0920.
PATRICi32117053. VBIEscCol129921_0951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74006.1.
AP009048 Genomic DNA. Translation: BAA35666.1.
D26440 Genomic DNA. No translation available.
PIRiG64831.
RefSeqiNP_415440.1. NC_000913.3.
WP_000899600.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AB01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263426. 296 interactions.
IntActiP0AB01. 3 interactions.
STRINGi511145.b0920.

Proteomic databases

EPDiP0AB01.
PaxDbiP0AB01.
PRIDEiP0AB01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74006; AAC74006; b0920.
BAA35666; BAA35666; BAA35666.
GeneIDi945546.
KEGGiecj:JW0903.
eco:b0920.
PATRICi32117053. VBIEscCol129921_0951.

Organism-specific databases

EchoBASEiEB2085.
EcoGeneiEG12166. elyC.

Phylogenomic databases

eggNOGiENOG4107S90. Bacteria.
COG1434. LUCA.
HOGENOMiHOG000259549.
InParanoidiP0AB01.
OMAiLWFTRWQ.
OrthoDBiEOG6SBT3M.
PhylomeDBiP0AB01.

Enzyme and pathway databases

BioCyciEcoCyc:EG12166-MONOMER.
ECOL316407:JW0903-MONOMER.

Miscellaneous databases

PROiP0AB01.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR003848. DUF218.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02698. DUF218. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "New killing system controlled by two genes located immediately upstream of the mukB gene in Escherichia coli."
    Feng J., Yamanaka K., Niki H., Ogura T., Hiraga S.
    Mol. Gen. Genet. 243:136-147(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-170.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "A genome-wide screen for bacterial envelope biogenesis mutants identifies a novel factor involved in cell wall precursor metabolism."
    Paradis-Bleau C., Kritikos G., Orlova K., Typas A., Bernhardt T.G.
    PLoS Genet. 10:E1004056-E1004056(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, GENE NAME.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiELYC_ECOLI
AccessioniPrimary (citable) accession number: P0AB01
Secondary accession number(s): P36565, P75846
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: March 16, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.