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Protein

Biofilm regulator BssR

Gene

bssR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway.1 Publication

GO - Biological processi

  • regulation of gene expression Source: EcoCyc
  • regulation of single-species biofilm formation Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G6436-MONOMER.
ECOL316407:JW0820-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Biofilm regulator BssR
Gene namesi
Name:bssR
Synonyms:yliH
Ordered Locus Names:b0836, JW0820
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13479. bssR.

Pathology & Biotechi

Disruption phenotypei

Cells show increased biofilm formation when glucose is present in the medium. In a continuous-flow system with M9C medium supplemented with glucose, the biofilm had a 290-fold greater biomass, a 2700-fold greater thickness and a 31-fold increased surface coverage than the wild-type.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Biofilm regulator BssRPRO_0000168732Add
BLAST

Proteomic databases

PaxDbiP0AAY1.

Interactioni

Protein-protein interaction databases

BioGridi4261844. 6 interactions.
STRINGi511145.b0836.

Structurei

3D structure databases

ProteinModelPortaliP0AAY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105UFT. Bacteria.
ENOG4111WGP. LUCA.
HOGENOMiHOG000118194.
KOiK19688.
OMAiYMSVSEN.
OrthoDBiEOG6VQPVS.

Family and domain databases

InterProiIPR020359. Biofilm_regulator_BssR.
[Graphical view]
PfamiPF10799. YliH. 1 hit.
[Graphical view]
ProDomiPD079626. Biofilm_regulator_BssR. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P0AAY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVDRQRIDL LNRLIDARVD LAAYVQLRKA KGYMSVSESN HLRDNFFKLN
60 70 80 90 100
RELHDKSLRL NLHLDQEEWS ALHHAEEALA TAAVCLMSGH HDCPTVITVN
110 120
ADKLENCLMS LTLSIQSLQK HAMLEKA
Length:127
Mass (Da):14,536
Last modified:October 11, 2005 - v1
Checksum:iF7BFD58CA74BC472
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73923.1.
AP009048 Genomic DNA. Translation: BAA35531.1.
PIRiD64821.
RefSeqiNP_415357.1. NC_000913.3.
WP_000497137.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73923; AAC73923; b0836.
BAA35531; BAA35531; BAA35531.
GeneIDi945466.
KEGGiecj:JW0820.
eco:b0836.
PATRICi32116875. VBIEscCol129921_0863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73923.1.
AP009048 Genomic DNA. Translation: BAA35531.1.
PIRiD64821.
RefSeqiNP_415357.1. NC_000913.3.
WP_000497137.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261844. 6 interactions.
STRINGi511145.b0836.

Proteomic databases

PaxDbiP0AAY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73923; AAC73923; b0836.
BAA35531; BAA35531; BAA35531.
GeneIDi945466.
KEGGiecj:JW0820.
eco:b0836.
PATRICi32116875. VBIEscCol129921_0863.

Organism-specific databases

EchoBASEiEB3252.
EcoGeneiEG13479. bssR.

Phylogenomic databases

eggNOGiENOG4105UFT. Bacteria.
ENOG4111WGP. LUCA.
HOGENOMiHOG000118194.
KOiK19688.
OMAiYMSVSEN.
OrthoDBiEOG6VQPVS.

Enzyme and pathway databases

BioCyciEcoCyc:G6436-MONOMER.
ECOL316407:JW0820-MONOMER.

Miscellaneous databases

PROiP0AAY1.

Family and domain databases

InterProiIPR020359. Biofilm_regulator_BssR.
[Graphical view]
PfamiPF10799. YliH. 1 hit.
[Graphical view]
ProDomiPD079626. Biofilm_regulator_BssR. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "YliH (BssR) and YceP (BssS) regulate Escherichia coli K-12 biofilm formation by influencing cell signaling."
    Domka J., Lee J., Wood T.K.
    Appl. Environ. Microbiol. 72:2449-2459(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    Strain: K12 / BW25113.

Entry informationi

Entry nameiBSSR_ECOLI
AccessioniPrimary (citable) accession number: P0AAY1
Secondary accession number(s): P75803
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: January 20, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.