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Protein

Miniconductance mechanosensitive channel YbdG

Gene

ybdG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks.1 Publication

Caution

Was originally thought to be the miniconductance mechanosensitive channel MscM.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • mechanosensitive ion channel activity Source: EcoCyc

GO - Biological processi

  • cellular response to osmotic stress Source: EcoCyc
  • ion transport Source: UniProtKB-KW
  • response to osmotic stress Source: EcoliWiki

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G6323-MONOMER

Protein family/group databases

TCDBi1.A.23.4.5 the small conductance mechanosensitive ion channel (mscs) family

Names & Taxonomyi

Protein namesi
Recommended name:
Miniconductance mechanosensitive channel YbdG
Gene namesi
Name:ybdG
Synonyms:mscM
Ordered Locus Names:b0577, JW0566
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12620 ybdG

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24PeriplasmicSequence analysisAdd BLAST24
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 67CytoplasmicSequence analysisAdd BLAST22
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 104PeriplasmicSequence analysisAdd BLAST16
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 148CytoplasmicSequence analysisAdd BLAST23
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 173PeriplasmicSequence analysis4
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 415CytoplasmicSequence analysisAdd BLAST221

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001686671 – 415Miniconductance mechanosensitive channel YbdGAdd BLAST415

Proteomic databases

PaxDbiP0AAT4
PRIDEiP0AAT4

Expressioni

Inductioni

Induced by growth at high osmolarity.1 Publication

Interactioni

Subunit structurei

Homoheptamer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1118850,EBI-1118850

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4262912, 25 interactors
DIPiDIP-51225N
IntActiP0AAT4, 4 interactors
STRINGi316385.ECDH10B_0643

Structurei

3D structure databases

ProteinModelPortaliP0AAT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CUY Bacteria
COG0668 LUCA
HOGENOMiHOG000199955
InParanoidiP0AAT4
KOiK16053
OMAiPTWRLMS
PhylomeDBiP0AAT4

Family and domain databases

InterProiView protein in InterPro
IPR010920 LSM_dom_sf
IPR011066 MscC_channel_C
IPR006685 MscS_channel
IPR030192 YbdG
PANTHERiPTHR30414 PTHR30414, 1 hit
PfamiView protein in Pfam
PF00924 MS_channel, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
SSF82689 SSF82689, 1 hit

Sequencei

Sequence statusi: Complete.

P0AAT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDLISQVED LAGIEIDHTT SMVMIFGIIF LTAVVVHIIL HWVVLRTFEK
60 70 80 90 100
RAIASSRLWL QIITQNKLFH RLAFTLQGII VNIQAVFWLQ KGTEAADILT
110 120 130 140 150
TCAQLWIMMY ALLSVFSLLD VILNLAQKFP AASQLPLKGI FQGIKLIGAI
160 170 180 190 200
LVGILMISLL IGQSPAILIS GLGAMAAVLM LVFKDPILGL VAGIQLSAND
210 220 230 240 250
MLKLGDWLEM PKYGADGAVI DIGLTTVKVR NWDNTITTIP TWSLVSDSFK
260 270 280 290 300
NWSGMSASGG RRIKRSISID VTSIRFLDED EMQRLNKAHL LKPYLTSRHQ
310 320 330 340 350
EINEWNRQQG STESVLNLRR MTNIGTFRAY LNEYLRNHPR IRKDMTLMVR
360 370 380 390 400
QLAPGDNGLP LEIYAFTNTV VWLEYESIQA DIFDHIFAIV EEFGLRLHQS
410
PTGNDIRSLA GAFKQ
Length:415
Mass (Da):46,603
Last modified:October 11, 2005 - v1
Checksum:iC9A8A8A41CDC8F28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA Translation: AAB40775.1
U00096 Genomic DNA Translation: AAC73678.1
AP009048 Genomic DNA Translation: BAA35217.1
U07860 Genomic DNA Translation: AAC43265.1
D25414 Genomic DNA No translation available.
PIRiG64790
RefSeqiNP_415109.1, NC_000913.3
WP_001153148.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73678; AAC73678; b0577
BAA35217; BAA35217; BAA35217
GeneIDi946243
KEGGiecj:JW0566
eco:b0577
PATRICifig|1411691.4.peg.1697

Similar proteinsi

Entry informationi

Entry nameiYBDG_ECOLI
AccessioniPrimary (citable) accession number: P0AAT4
Secondary accession number(s): P39455, P77602
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 25, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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