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Protein

Hha toxicity modulator TomB

Gene

tomB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA.2 Publications

GO - Molecular functioni

  • DNA binding Source: EcoCyc

GO - Biological processi

  • single-species biofilm formation Source: EcoCyc
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12429-MONOMER.
ECOL316407:JW0450-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hha toxicity modulator TomB
Alternative name(s):
Toxin overexpression modulator in biofilms
Gene namesi
Name:tomB
Synonyms:ybaJ
Ordered Locus Names:b0461, JW0450
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12429. tomB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Deletion of hha and tomB, in the presence of a conjugative plasmid (R1drd19), decreases biofilm formation, cell aggregation and increases motility via flagella and motility gene expression.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 124124Hha toxicity modulator TomBPRO_0000168617Add
BLAST

Proteomic databases

PaxDbiP0AAR0.

Expressioni

Inductioni

Expression is autoregulated (Probable). Induced during biofilm formation.Curated2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4259498. 27 interactions.
DIPiDIP-48132N.
STRINGi511145.b0461.

Structurei

3D structure databases

ProteinModelPortaliP0AAR0.
SMRiP0AAR0. Positions 1-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TomB family.Curated

Phylogenomic databases

eggNOGiENOG4108UKR. Bacteria.
ENOG4111JW6. LUCA.
HOGENOMiHOG000219356.
KOiK19162.
OMAiCERVEKY.

Family and domain databases

InterProiIPR019693. Biofilm_formation_reg_YbaJ.
[Graphical view]
PfamiPF10757. YbaJ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AAR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEYSPKRHD IAQLKFLCET LYHDCLANLE ESNHGWVNDP TSAINLQLNE
60 70 80 90 100
LIEHIATFAL NYKIKYNEDN KLIEQIDEYL DDTFMLFSSY GINMQDLQKW
110 120
RKSGNRLFRC FVNATKENPA SLSC
Length:124
Mass (Da):14,557
Last modified:October 11, 2005 - v1
Checksum:i5F410DFFBD29F270
GO

Sequence cautioni

The sequence X57977 differs from that shown. Reason: Frameshift at positions 43 and 53. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73563.1.
AP009048 Genomic DNA. Translation: BAE76240.1.
X57977 Genomic DNA. No translation available.
PIRiD64776.
RefSeqiNP_414994.1. NC_000913.3.
WP_000344800.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73563; AAC73563; b0461.
BAE76240; BAE76240; BAE76240.
GeneIDi945106.
KEGGiecj:JW0450.
eco:b0461.
PATRICi32116075. VBIEscCol129921_0479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73563.1.
AP009048 Genomic DNA. Translation: BAE76240.1.
X57977 Genomic DNA. No translation available.
PIRiD64776.
RefSeqiNP_414994.1. NC_000913.3.
WP_000344800.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAR0.
SMRiP0AAR0. Positions 1-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259498. 27 interactions.
DIPiDIP-48132N.
STRINGi511145.b0461.

Proteomic databases

PaxDbiP0AAR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73563; AAC73563; b0461.
BAE76240; BAE76240; BAE76240.
GeneIDi945106.
KEGGiecj:JW0450.
eco:b0461.
PATRICi32116075. VBIEscCol129921_0479.

Organism-specific databases

EchoBASEiEB2326.
EcoGeneiEG12429. tomB.

Phylogenomic databases

eggNOGiENOG4108UKR. Bacteria.
ENOG4111JW6. LUCA.
HOGENOMiHOG000219356.
KOiK19162.
OMAiCERVEKY.

Enzyme and pathway databases

BioCyciEcoCyc:EG12429-MONOMER.
ECOL316407:JW0450-MONOMER.

Miscellaneous databases

PROiP0AAR0.

Family and domain databases

InterProiIPR019693. Biofilm_formation_reg_YbaJ.
[Graphical view]
PfamiPF10757. YbaJ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOMB_ECOLI
AccessioniPrimary (citable) accession number: P0AAR0
Secondary accession number(s): P37611, P75708, Q2MBW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Hha and TomB may form a toxin-antitoxin (TA) module.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.