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Protein

Hha toxicity modulator TomB

Gene

tomB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA.2 Publications

Miscellaneous

Hha and TomB may form a type II toxin-antitoxin (TA) system (PubMed:18545668).1 Publication

GO - Molecular functioni

  • DNA binding Source: EcoCyc

GO - Biological processi

  • single-species biofilm formation Source: EcoCyc

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12429-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Hha toxicity modulator TomB
Alternative name(s):
Toxin overexpression modulator in biofilms
Gene namesi
Name:tomB
Synonyms:ybaJ
Ordered Locus Names:b0461, JW0450
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12429 tomB

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Deletion of hha and tomB, in the presence of a conjugative plasmid (R1drd19), decreases biofilm formation, cell aggregation and increases motility via flagella and motility gene expression.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001686171 – 124Hha toxicity modulator TomBAdd BLAST124

Proteomic databases

PaxDbiP0AAR0
PRIDEiP0AAR0

Expressioni

Inductioni

Expression is autoregulated (Probable). Induced during biofilm formation.Curated2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4259498, 27 interactors
DIPiDIP-48132N
STRINGi316385.ECDH10B_0417

Structurei

3D structure databases

ProteinModelPortaliP0AAR0
SMRiP0AAR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TomB family.Curated

Phylogenomic databases

eggNOGiENOG4108UKR Bacteria
ENOG4111JW6 LUCA
HOGENOMiHOG000219356
KOiK19162
OMAiCERVEKY

Family and domain databases

InterProiView protein in InterPro
IPR019693 Biofilm_formation_reg_YbaJ
PfamiView protein in Pfam
PF10757 YbaJ, 1 hit

Sequencei

Sequence statusi: Complete.

P0AAR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEYSPKRHD IAQLKFLCET LYHDCLANLE ESNHGWVNDP TSAINLQLNE
60 70 80 90 100
LIEHIATFAL NYKIKYNEDN KLIEQIDEYL DDTFMLFSSY GINMQDLQKW
110 120
RKSGNRLFRC FVNATKENPA SLSC
Length:124
Mass (Da):14,557
Last modified:October 11, 2005 - v1
Checksum:i5F410DFFBD29F270
GO

Sequence cautioni

The sequence X57977 differs from that shown. Reason: Frameshift at positions 43 and 53.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73563.1
AP009048 Genomic DNA Translation: BAE76240.1
X57977 Genomic DNA No translation available.
PIRiD64776
RefSeqiNP_414994.1, NC_000913.3
WP_000344800.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73563; AAC73563; b0461
BAE76240; BAE76240; BAE76240
GeneIDi945106
KEGGiecj:JW0450
eco:b0461
PATRICifig|1411691.4.peg.1815

Similar proteinsi

Entry informationi

Entry nameiTOMB_ECOLI
AccessioniPrimary (citable) accession number: P0AAR0
Secondary accession number(s): P37611, P75708, Q2MBW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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