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Protein

Inhibitor of hydrogen peroxide resistance

Gene

iprA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in oxidative stress resistance.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi163 – 182H-T-H motifUniRule annotationAdd BLAST20

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciEcoCyc:G6226-MONOMER.
ECOL316407:JW0366-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of hydrogen peroxide resistanceUniRule annotation
Gene namesi
Name:iprAUniRule annotation
Synonyms:yaiV
Ordered Locus Names:b0375, JW0366
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13607. yaiV.

Pathology & Biotechi

Disruption phenotypei

Deletion mutants display increased resistance to oxidative stress and increased catalase activity.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001685961 – 207Inhibitor of hydrogen peroxide resistanceAdd BLAST207

Proteomic databases

PaxDbiP0AAP5.
PRIDEiP0AAP5.

Interactioni

Protein-protein interaction databases

BioGridi4259481. 153 interactors.
IntActiP0AAP5. 3 interactors.
STRINGi511145.b0375.

Structurei

3D structure databases

ProteinModelPortaliP0AAP5.
SMRiP0AAP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IprA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108PNB. Bacteria.
ENOG410ZQUT. LUCA.
HOGENOMiHOG000117456.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_02072. IprA. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AAP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSVVKPLQE FGKLDKCLSR YGTRFEFNNE KQVIFSSDVN NEDTFVILEG
60 70 80 90 100
VISLRREENV LIGITQAPYI MGLADGLMKN DIPYKLISEG NCTGYHLPAK
110 120 130 140 150
QTITLIEQNQ LWRDAFYWLA WQNRILELRD VQLIGHNSYE QIRATLLSMI
160 170 180 190 200
DWNEELRSRI GVMNYIHQRT RISRSVVAEV LAALRKGGYI EMNKGKLVAI

NRLPSEY
Length:207
Mass (Da):23,956
Last modified:November 24, 2009 - v2
Checksum:iE58258DC6F00E505
GO

Sequence cautioni

The sequence AAB18098 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE76156 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18098.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73478.2.
AP009048 Genomic DNA. Translation: BAE76156.1. Different initiation.
PIRiG64765.
RefSeqiNP_414909.2. NC_000913.3.
WP_001295335.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73478; AAC73478; b0375.
BAE76156; BAE76156; BAE76156.
GeneIDi946902.
KEGGiecj:JW0366.
eco:b0375.
PATRICi32115889. VBIEscCol129921_0386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18098.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73478.2.
AP009048 Genomic DNA. Translation: BAE76156.1. Different initiation.
PIRiG64765.
RefSeqiNP_414909.2. NC_000913.3.
WP_001295335.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAP5.
SMRiP0AAP5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259481. 153 interactors.
IntActiP0AAP5. 3 interactors.
STRINGi511145.b0375.

Proteomic databases

PaxDbiP0AAP5.
PRIDEiP0AAP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73478; AAC73478; b0375.
BAE76156; BAE76156; BAE76156.
GeneIDi946902.
KEGGiecj:JW0366.
eco:b0375.
PATRICi32115889. VBIEscCol129921_0386.

Organism-specific databases

EchoBASEiEB3374.
EcoGeneiEG13607. yaiV.

Phylogenomic databases

eggNOGiENOG4108PNB. Bacteria.
ENOG410ZQUT. LUCA.
HOGENOMiHOG000117456.

Enzyme and pathway databases

BioCyciEcoCyc:G6226-MONOMER.
ECOL316407:JW0366-MONOMER.

Miscellaneous databases

PROiP0AAP5.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_02072. IprA. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIPRA_ECOLI
AccessioniPrimary (citable) accession number: P0AAP5
Secondary accession number(s): P77723, Q2MC50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: November 24, 2009
Last modified: November 30, 2016
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.