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Protein

Transcriptional repressor FrmR

Gene

frmR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Repressor of the frmRAB operon.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6209-MONOMER.
ECOL316407:JW0348-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor FrmR
Gene namesi
Name:frmR
Synonyms:yaiN
Ordered Locus Names:b0357, JW0348
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13296. frmR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001685911 – 91Transcriptional repressor FrmRAdd BLAST91

Proteomic databases

PaxDbiP0AAP3.
PRIDEiP0AAP3.

Expressioni

Inductioni

Induced by formaldehyde. Negatively autoregulated.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261804. 11 interactors.
DIPiDIP-48245N.
IntActiP0AAP3. 2 interactors.
STRINGi511145.b0357.

Structurei

3D structure databases

ProteinModelPortaliP0AAP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FrmR/RcnR family.Curated

Phylogenomic databases

eggNOGiENOG4105VEG. Bacteria.
COG1937. LUCA.
HOGENOMiHOG000023914.
InParanoidiP0AAP3.
OMAiHIRDHLM.
PhylomeDBiP0AAP3.

Family and domain databases

InterProiIPR003735. Metal_Tscrpt_repr.
[Graphical view]
PfamiPF02583. Trns_repr_metal. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AAP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSTPEEKKK VLTRVRRIRG QIDALERSLE GDAECRAILQ QIAAVRGAAN
60 70 80 90
GLMAEVLESH IRETFDRNDC YSREVSQSVD DTIELVRAYL K
Length:91
Mass (Da):10,318
Last modified:October 11, 2005 - v1
Checksum:i23305017AAB2C22D
GO

Sequence cautioni

The sequence AAB18082 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence D85613 differs from that shown. Reason: Frameshift at position 20.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85613 Genomic DNA. No translation available.
U73857 Genomic DNA. Translation: AAB18082.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73460.2.
AP009048 Genomic DNA. Translation: BAE76139.1.
RefSeqiNP_414891.4. NC_000913.3.
WP_001141271.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73460; AAC73460; b0357.
BAE76139; BAE76139; BAE76139.
GeneIDi944986.
KEGGiecj:JW0348.
eco:b0357.
PATRICi32115853. VBIEscCol129921_0368.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85613 Genomic DNA. No translation available.
U73857 Genomic DNA. Translation: AAB18082.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73460.2.
AP009048 Genomic DNA. Translation: BAE76139.1.
RefSeqiNP_414891.4. NC_000913.3.
WP_001141271.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAP3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261804. 11 interactors.
DIPiDIP-48245N.
IntActiP0AAP3. 2 interactors.
STRINGi511145.b0357.

Proteomic databases

PaxDbiP0AAP3.
PRIDEiP0AAP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73460; AAC73460; b0357.
BAE76139; BAE76139; BAE76139.
GeneIDi944986.
KEGGiecj:JW0348.
eco:b0357.
PATRICi32115853. VBIEscCol129921_0368.

Organism-specific databases

EchoBASEiEB3081.
EcoGeneiEG13296. frmR.

Phylogenomic databases

eggNOGiENOG4105VEG. Bacteria.
COG1937. LUCA.
HOGENOMiHOG000023914.
InParanoidiP0AAP3.
OMAiHIRDHLM.
PhylomeDBiP0AAP3.

Enzyme and pathway databases

BioCyciEcoCyc:G6209-MONOMER.
ECOL316407:JW0348-MONOMER.

Miscellaneous databases

PROiP0AAP3.

Family and domain databases

InterProiIPR003735. Metal_Tscrpt_repr.
[Graphical view]
PfamiPF02583. Trns_repr_metal. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFRMR_ECOLI
AccessioniPrimary (citable) accession number: P0AAP3
Secondary accession number(s): P55756, P77584, Q2MC67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.