Reviewed, UniProtKB/Swiss-Prot P0AAP1 (ADRA_ECOLI)

Names and origin

Protein names

Recommended name:
    Protein adrA

Gene names

Name:	adrA
Synonyms:	yaiC
Ordered Locus Names:	b0385, JW0376

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Contains 1 GGDEF domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Protein adrA		PRO_0000168588
Regions
	Transmembrane	46 – 66	21	Potential
	Transmembrane	68 – 88	21	Potential
	Transmembrane	112 – 132	21	Potential
	Transmembrane	143 – 163	21	Potential
	Transmembrane	171 – 191	21	Potential
	Domain	240 – 371	132	GGDEF

Sequences

	Sequence		Length	Mass (Da)
	P0AAP1-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 1F5111C43481F32B	FASTA	371	41,537
	10 20 30 40 50 60 MFPKIMNDEN FFKKAAAHGE EPPLTPQNEH QRSGLRFARR VRLPRAVGLA GMFLPIASTL 70 80 90 100 110 120 VSHPPPGWWW LVLVGWAFVW PHLAWQIASR AVDPLSREIY NLKTDAVLAG MWVGVMGVNV 130 140 150 160 170 180 LPSTAMLMIM CLNLMGAGGP RLFVAGLVLM VVSCLVTLEL TGITVSFNSA PLEWWLSLPI 190 200 210 220 230 240 IVIYPLLFGW VSYQTATKLA EHKRRLQVMS TRDGMTGVYN RRHWETMLRN EFDNCRRHNR 250 260 270 280 290 300 DATLLIIDID HFKSINDTWG HDVGDEAIVA LTRQLQITLR GSDVIGRFGG DEFAVIMSGT 310 320 330 340 350 360 PAESAITAML RVHEGLNTLR LPNTPQVTLR ISVGVAPLNP QMSHYREWLK SADLALYKAK 370 KAGRNRTEVA A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"Nucleotide sequence of the alkaline phosphatase gene of Escherichia coli." Chang C.N., Kuang W.-J., Chen E.Y. Gene 44:121-125(1986) [PubMed: 3533724] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-159. Strain: K12.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U73857 Genomic DNA. Translation: AAB18109.1. U00096 Genomic DNA. Translation: AAC73488.1. AP009048 Genomic DNA. Translation: BAE76166.1. M13345 Genomic DNA. Translation: AAA83895.1.
PIR	A64767.
RefSeq	AP_001036.1. NP_414919.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P0AAP1.
Genome annotation databases
GeneID	945037.
GenomeReviews	Gene locus JW0376 in contig AP009048_GR. Gene locus b0385 in contig U00096_GR.
KEGG	ecj:JW0376. eco:b0385.
Organism-specific databases
EchoBASE	EB1237.
EcoGene	EG11257. adrA.
CMR	Search...
Phylogenomic databases
HOGENOM	P0AAP1.
OMA	LGARHES
Enzyme and pathway databases
BioCyc	EcoCyc:EG11257-MON. ECOL168927:B0385-MON.
Gene expression databases
Genevestigator	P0AAP1.
Family and domain databases
InterPro	IPR000160. Diguanylate_cyclase-pred. IPR007894. MASE2. [Graphical view]
Pfam	PF00990. GGDEF. 1 hit. PF05230. MASE2. 1 hit. [Graphical view]
SMART	SM00267. GGDEF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00254. GGDEF. 1 hit.
PROSITE	PS50887. GGDEF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADRA_ECOLI

Accession

Primary (citable) accession number: P0AAP1
Secondary accession number(s): P21830, P77719, Q2MC40

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	November 24, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)