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Protein

Hydrogenase-2 operon protein HybE

Gene

hybE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • preprotein binding Source: EcoCyc

GO - Biological processi

  • protein maturation Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG11803-MONOMER.
ECOL316407:JW2960-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase-2 operon protein HybE
Gene namesi
Name:hybE
Ordered Locus Names:b2992, JW2960
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11803. hybE.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Hydrogenase-2 operon protein HybEPRO_0000201426Add
BLAST

Proteomic databases

PaxDbiP0AAN1.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
hybOP697414EBI-552588,EBI-552619

GO - Molecular functioni

  • preprotein binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4262373. 10 interactions.
DIPiDIP-35795N.
IntActiP0AAN1. 7 interactions.
MINTiMINT-1305432.
STRINGi511145.b2992.

Structurei

Secondary structure

1
162
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63Combined sources
Helixi13 – 2311Combined sources
Helixi29 – 313Combined sources
Beta strandi41 – 488Combined sources
Beta strandi51 – 577Combined sources
Beta strandi62 – 687Combined sources
Beta strandi73 – 753Combined sources
Beta strandi82 – 854Combined sources
Beta strandi92 – 998Combined sources
Turni100 – 1023Combined sources
Beta strandi103 – 1119Combined sources
Helixi120 – 13516Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KC5NMR-A1-162[»]
ProteinModelPortaliP0AAN1.
SMRiP0AAN1. Positions 1-162.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AAN1.

Family & Domainsi

Sequence similaritiesi

Belongs to the HupJ family.Curated

Phylogenomic databases

eggNOGiENOG4108WGS. Bacteria.
ENOG4111JT6. LUCA.
HOGENOMiHOG000278778.
InParanoidiP0AAN1.
OMAiLTPWMIS.

Family and domain databases

InterProiIPR023994. NiFe-hyd_HybE.
[Graphical view]
PfamiPF11939. DUF3457. 1 hit.
[Graphical view]
ProDomiPD008308. PD008308. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR03993. hydrog_HybE. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AAN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEEIAGFQT SPKAQVQAAF EEIARRSMHD LSFLHPSMPV YVSDFTLFEG
60 70 80 90 100
QWTGCVITPW MLSAVIFPGP DQLWPLRKVS EKIGLQLPYG TMTFTVGELD
110 120 130 140 150
GVSQYLSCSL MSPLSHSMSI EEGQRLTDDC ARMILSLPVT NPDVPHAGRR
160
ALLFGRRSGE NA
Length:162
Mass (Da):17,964
Last modified:October 11, 2005 - v1
Checksum:iCFDAEA3D47BE9516
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71G → A in AAA21593 (PubMed:8021226).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09177 Genomic DNA. Translation: AAA21593.1.
U28377 Genomic DNA. Translation: AAA69159.1.
U00096 Genomic DNA. Translation: AAC76028.1.
AP009048 Genomic DNA. Translation: BAE77053.1.
PIRiF65085.
RefSeqiNP_417466.1. NC_000913.3.
WP_000134014.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76028; AAC76028; b2992.
BAE77053; BAE77053; BAE77053.
GeneIDi947483.
KEGGiecj:JW2960.
eco:b2992.
PATRICi32121400. VBIEscCol129921_3087.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09177 Genomic DNA. Translation: AAA21593.1.
U28377 Genomic DNA. Translation: AAA69159.1.
U00096 Genomic DNA. Translation: AAC76028.1.
AP009048 Genomic DNA. Translation: BAE77053.1.
PIRiF65085.
RefSeqiNP_417466.1. NC_000913.3.
WP_000134014.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KC5NMR-A1-162[»]
ProteinModelPortaliP0AAN1.
SMRiP0AAN1. Positions 1-162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262373. 10 interactions.
DIPiDIP-35795N.
IntActiP0AAN1. 7 interactions.
MINTiMINT-1305432.
STRINGi511145.b2992.

Proteomic databases

PaxDbiP0AAN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76028; AAC76028; b2992.
BAE77053; BAE77053; BAE77053.
GeneIDi947483.
KEGGiecj:JW2960.
eco:b2992.
PATRICi32121400. VBIEscCol129921_3087.

Organism-specific databases

EchoBASEiEB1751.
EcoGeneiEG11803. hybE.

Phylogenomic databases

eggNOGiENOG4108WGS. Bacteria.
ENOG4111JT6. LUCA.
HOGENOMiHOG000278778.
InParanoidiP0AAN1.
OMAiLTPWMIS.

Enzyme and pathway databases

BioCyciEcoCyc:EG11803-MONOMER.
ECOL316407:JW2960-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0AAN1.
PROiP0AAN1.

Family and domain databases

InterProiIPR023994. NiFe-hyd_HybE.
[Graphical view]
PfamiPF11939. DUF3457. 1 hit.
[Graphical view]
ProDomiPD008308. PD008308. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR03993. hydrog_HybE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHYBE_ECOLI
AccessioniPrimary (citable) accession number: P0AAN1
Secondary accession number(s): P37183, Q2M9K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.