Reviewed, UniProtKB/Swiss-Prot P0AAN1 (HYBE_ECOLI)

Names and origin

Protein names

Recommended name:
    Hydrogenase-2 operon protein hybE

Gene names

Name:	hybE
Ordered Locus Names:	b2992, JW2960

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	162 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the hupJ family.

Ontologies

Keywords
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
hybO	P69741	2	EBI-552588,EBI-552619
ptsN	P69829	1	EBI-552588,EBI-547017

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 162	162	Hydrogenase-2 operon protein hybE		PRO_0000201426
Experimental info
	Sequence conflict	7	1	G → A in AAA21593. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P0AAN1-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: CFDAEA3D47BE9516	FASTA	162	17,964
	10 20 30 40 50 60 MTEEIAGFQT SPKAQVQAAF EEIARRSMHD LSFLHPSMPV YVSDFTLFEG QWTGCVITPW 70 80 90 100 110 120 MLSAVIFPGP DQLWPLRKVS EKIGLQLPYG TMTFTVGELD GVSQYLSCSL MSPLSHSMSI 130 140 150 160 EEGQRLTDDC ARMILSLPVT NPDVPHAGRR ALLFGRRSGE NA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequencing, and mutational analysis of the hyb operon encoding Escherichia coli hydrogenase 2." Menon N.K., Chatelus C.Y., Dervartanian M., Wendt J.C., Shanmugam K.T., Peck H.D. Jr., Przybyla A.E. J. Bacteriol. 176:4416-4423(1994) [PubMed: 8021226] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / TG1.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U09177 Genomic DNA. Translation: AAA21593.1. U28377 Genomic DNA. Translation: AAA69159.1. U00096 Genomic DNA. Translation: AAC76028.1. AP009048 Genomic DNA. Translation: BAE77053.1.
PIR	F65085.
RefSeq	AP_003547.1. NP_417466.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P0AAN1. 7 interactions.
Genome annotation databases
GeneID	947483.
GenomeReviews	Gene locus JW2960 in contig AP009048_GR. Gene locus b2992 in contig U00096_GR.
KEGG	ecj:JW2960. eco:b2992.
Organism-specific databases
EchoBASE	EB1751.
EcoGene	EG11803. hybE.
CMR	Search...
Phylogenomic databases
HOGENOM	P0AAN1.
OMA	P0AAN1. LTPWMLS.
Enzyme and pathway databases
BioCyc	EcoCyc:EG11803-MON.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

HYBE_ECOLI

Accession

Primary (citable) accession number: P0AAN1
Secondary accession number(s): P37183, Q2M9K3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)