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Protein

Hydrogenase isoenzymes formation protein HypC

Gene

hypC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Is required for the formation of all three hydrogenase isoenzymes. May bind to the precursor form of the large subunit of dehydrogenases to keep them in a conformation accessible for metal incorporation.

GO - Molecular functioni

  • carbon dioxide binding Source: EcoCyc
  • identical protein binding Source: EcoCyc
  • iron ion binding Source: EcoCyc

GO - Biological processi

  • protein maturation Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG10485-MONOMER.
ECOL316407:JW2698-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase isoenzymes formation protein HypC
Gene namesi
Name:hypC
Ordered Locus Names:b2728, JW2698
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10485. hypC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002013981 – 90Hydrogenase isoenzymes formation protein HypCAdd BLAST90

Proteomic databases

PaxDbiP0AAM3.
PRIDEiP0AAM3.

Interactioni

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4261426. 9 interactors.
DIPiDIP-36430N.
IntActiP0AAM3. 9 interactors.
MINTiMINT-1223094.
STRINGi511145.b2728.

Structurei

Secondary structure

190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 12Combined sources9
Beta strandi14 – 20Combined sources7
Beta strandi22 – 29Combined sources8
Turni31 – 33Combined sources3
Beta strandi47 – 51Combined sources5
Beta strandi54 – 59Combined sources6
Helixi61 – 76Combined sources16
Helixi80 – 85Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OT2NMR-A1-90[»]
ProteinModelPortaliP0AAM3.
SMRiP0AAM3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AAM3.

Family & Domainsi

Sequence similaritiesi

Belongs to the HupF/HypC family.Curated

Phylogenomic databases

eggNOGiENOG41083WG. Bacteria.
COG0298. LUCA.
HOGENOMiHOG000278755.
InParanoidiP0AAM3.
KOiK04653.
OMAiQKMGADY.
PhylomeDBiP0AAM3.

Family and domain databases

InterProiIPR019812. Hydgase_assmbl_chp_CS.
IPR001109. Hydrogenase_HupF/HypC.
[Graphical view]
PfamiPF01455. HupF_HypC. 1 hit.
[Graphical view]
PRINTSiPR00445. HUPFHYPC.
TIGRFAMsiTIGR00074. hypC_hupF. 1 hit.
PROSITEiPS01097. HUPF_HYPC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AAM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCIGVPGQIR TIDGNQAKVD VCGIQRDVDL TLVGSCDENG QPRVGQWVLV
60 70 80 90
HVGFAMSVIN EAEARDTLDA LQNMFDVEPD VGALLYGEEK
Length:90
Mass (Da):9,732
Last modified:October 11, 2005 - v1
Checksum:iFBE252F1875C7879
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54543 Genomic DNA. Translation: CAA38414.1.
U29579 Genomic DNA. Translation: AAA69238.1.
U00096 Genomic DNA. Translation: AAC75770.1.
AP009048 Genomic DNA. Translation: BAE76805.1.
PIRiS15199.
RefSeqiNP_417208.1. NC_000913.3.
WP_000334881.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75770; AAC75770; b2728.
BAE76805; BAE76805; BAE76805.
GeneIDi947192.
KEGGiecj:JW2698.
eco:b2728.
PATRICi32120856. VBIEscCol129921_2820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54543 Genomic DNA. Translation: CAA38414.1.
U29579 Genomic DNA. Translation: AAA69238.1.
U00096 Genomic DNA. Translation: AAC75770.1.
AP009048 Genomic DNA. Translation: BAE76805.1.
PIRiS15199.
RefSeqiNP_417208.1. NC_000913.3.
WP_000334881.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OT2NMR-A1-90[»]
ProteinModelPortaliP0AAM3.
SMRiP0AAM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261426. 9 interactors.
DIPiDIP-36430N.
IntActiP0AAM3. 9 interactors.
MINTiMINT-1223094.
STRINGi511145.b2728.

Proteomic databases

PaxDbiP0AAM3.
PRIDEiP0AAM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75770; AAC75770; b2728.
BAE76805; BAE76805; BAE76805.
GeneIDi947192.
KEGGiecj:JW2698.
eco:b2728.
PATRICi32120856. VBIEscCol129921_2820.

Organism-specific databases

EchoBASEiEB0480.
EcoGeneiEG10485. hypC.

Phylogenomic databases

eggNOGiENOG41083WG. Bacteria.
COG0298. LUCA.
HOGENOMiHOG000278755.
InParanoidiP0AAM3.
KOiK04653.
OMAiQKMGADY.
PhylomeDBiP0AAM3.

Enzyme and pathway databases

BioCyciEcoCyc:EG10485-MONOMER.
ECOL316407:JW2698-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0AAM3.
PROiP0AAM3.

Family and domain databases

InterProiIPR019812. Hydgase_assmbl_chp_CS.
IPR001109. Hydrogenase_HupF/HypC.
[Graphical view]
PfamiPF01455. HupF_HypC. 1 hit.
[Graphical view]
PRINTSiPR00445. HUPFHYPC.
TIGRFAMsiTIGR00074. hypC_hupF. 1 hit.
PROSITEiPS01097. HUPF_HYPC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHYPC_ECOLI
AccessioniPrimary (citable) accession number: P0AAM3
Secondary accession number(s): P24191, Q2MAA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.