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P0AAM3

- HYPC_ECOLI

UniProt

P0AAM3 - HYPC_ECOLI

Protein

Hydrogenase isoenzymes formation protein HypC

Gene

hypC

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Is required for the formation of all three hydrogenase isoenzymes. May bind to the precursor form of the large subunit of dehydrogenases to keep them in a conformation accessible for metal incorporation.

    GO - Molecular functioni

    1. carbon dioxide binding Source: EcoCyc
    2. identical protein binding Source: EcoCyc
    3. iron ion binding Source: EcoCyc
    4. protein binding Source: EcoCyc

    GO - Biological processi

    1. protein maturation Source: EcoCyc

    Enzyme and pathway databases

    BioCyciEcoCyc:EG10485-MONOMER.
    ECOL316407:JW2698-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydrogenase isoenzymes formation protein HypC
    Gene namesi
    Name:hypC
    Ordered Locus Names:b2728, JW2698
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG10485. hypC.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9090Hydrogenase isoenzymes formation protein HypCPRO_0000201398Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP0AAM3.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-36430N.
    IntActiP0AAM3. 9 interactions.
    MINTiMINT-1223094.
    STRINGi511145.b2728.

    Structurei

    Secondary structure

    1
    90
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 129
    Beta strandi14 – 207
    Beta strandi22 – 298
    Turni31 – 333
    Beta strandi47 – 515
    Beta strandi54 – 596
    Helixi61 – 7616
    Helixi80 – 856

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2OT2NMR-A1-90[»]
    ProteinModelPortaliP0AAM3.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0AAM3.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HupF/HypC family.Curated

    Phylogenomic databases

    eggNOGiCOG0298.
    HOGENOMiHOG000278755.
    KOiK04653.
    OMAiVCMNRIL.
    OrthoDBiEOG6GR3F3.
    PhylomeDBiP0AAM3.

    Family and domain databases

    InterProiIPR019812. Hydgase_assmbl_chp_CS.
    IPR001109. Hydrogenase_HupF/HypC.
    [Graphical view]
    PfamiPF01455. HupF_HypC. 1 hit.
    [Graphical view]
    PRINTSiPR00445. HUPFHYPC.
    TIGRFAMsiTIGR00074. hypC_hupF. 1 hit.
    PROSITEiPS01097. HUPF_HYPC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0AAM3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCIGVPGQIR TIDGNQAKVD VCGIQRDVDL TLVGSCDENG QPRVGQWVLV   50
    HVGFAMSVIN EAEARDTLDA LQNMFDVEPD VGALLYGEEK 90
    Length:90
    Mass (Da):9,732
    Last modified:October 11, 2005 - v1
    Checksum:iFBE252F1875C7879
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54543 Genomic DNA. Translation: CAA38414.1.
    U29579 Genomic DNA. Translation: AAA69238.1.
    U00096 Genomic DNA. Translation: AAC75770.1.
    AP009048 Genomic DNA. Translation: BAE76805.1.
    PIRiS15199.
    RefSeqiNP_417208.1. NC_000913.3.
    YP_490937.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC75770; AAC75770; b2728.
    BAE76805; BAE76805; BAE76805.
    GeneIDi12932432.
    947192.
    KEGGiecj:Y75_p2666.
    eco:b2728.
    PATRICi32120856. VBIEscCol129921_2820.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54543 Genomic DNA. Translation: CAA38414.1 .
    U29579 Genomic DNA. Translation: AAA69238.1 .
    U00096 Genomic DNA. Translation: AAC75770.1 .
    AP009048 Genomic DNA. Translation: BAE76805.1 .
    PIRi S15199.
    RefSeqi NP_417208.1. NC_000913.3.
    YP_490937.1. NC_007779.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2OT2 NMR - A 1-90 [» ]
    ProteinModelPortali P0AAM3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-36430N.
    IntActi P0AAM3. 9 interactions.
    MINTi MINT-1223094.
    STRINGi 511145.b2728.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC75770 ; AAC75770 ; b2728 .
    BAE76805 ; BAE76805 ; BAE76805 .
    GeneIDi 12932432.
    947192.
    KEGGi ecj:Y75_p2666.
    eco:b2728.
    PATRICi 32120856. VBIEscCol129921_2820.

    Organism-specific databases

    EchoBASEi EB0480.
    EcoGenei EG10485. hypC.

    Phylogenomic databases

    eggNOGi COG0298.
    HOGENOMi HOG000278755.
    KOi K04653.
    OMAi VCMNRIL.
    OrthoDBi EOG6GR3F3.
    PhylomeDBi P0AAM3.

    Enzyme and pathway databases

    BioCyci EcoCyc:EG10485-MONOMER.
    ECOL316407:JW2698-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P0AAM3.
    PROi P0AAM3.

    Gene expression databases

    Genevestigatori P0AAM3.

    Family and domain databases

    InterProi IPR019812. Hydgase_assmbl_chp_CS.
    IPR001109. Hydrogenase_HupF/HypC.
    [Graphical view ]
    Pfami PF01455. HupF_HypC. 1 hit.
    [Graphical view ]
    PRINTSi PR00445. HUPFHYPC.
    TIGRFAMsi TIGR00074. hypC_hupF. 1 hit.
    PROSITEi PS01097. HUPF_HYPC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of an operon (hyp) necessary for the activity of the three hydrogenase isoenzymes in Escherichia coli."
      Lutz S., Jacobi A., Schlensog V., Boehm R., Sawers G., Boeck A.
      Mol. Microbiol. 5:123-135(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. "Escherichia coli proteome analysis using the gene-protein database."
      VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.
      Electrophoresis 18:1243-1251(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY 2D-GEL.
    5. "Interaction of the hydrogenase accessory protein HypC with HycE, the large subunit of Escherichia coli hydrogenase 3 during enzyme maturation."
      Drapal N., Boeck A.
      Biochemistry 37:2941-2948(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE FUNCTION.

    Entry informationi

    Entry nameiHYPC_ECOLI
    AccessioniPrimary (citable) accession number: P0AAM3
    Secondary accession number(s): P24191, Q2MAA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3