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P0AAM3 (HYPC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydrogenase isoenzymes formation protein HypC
Gene names
Name:hypC
Ordered Locus Names:b2728, JW2698
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length90 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Is required for the formation of all three hydrogenase isoenzymes. May bind to the precursor form of the large subunit of dehydrogenases to keep them in a conformation accessible for metal incorporation. Ref.5

Sequence similarities

Belongs to the HupF/HypC family.

Ontologies

Keywords
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein maturation

Inferred from direct assay PubMed 8756471. Source: EcoCyc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9090Hydrogenase isoenzymes formation protein HypC
PRO_0000201398

Secondary structure

................. 90
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0AAM3 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: FBE252F1875C7879

FASTA909,732
        10         20         30         40         50         60 
MCIGVPGQIR TIDGNQAKVD VCGIQRDVDL TLVGSCDENG QPRVGQWVLV HVGFAMSVIN 

        70         80         90 
EAEARDTLDA LQNMFDVEPD VGALLYGEEK 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization of an operon (hyp) necessary for the activity of the three hydrogenase isoenzymes in Escherichia coli."
Lutz S., Jacobi A., Schlensog V., Boehm R., Sawers G., Boeck A.
Mol. Microbiol. 5:123-135(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Escherichia coli proteome analysis using the gene-protein database."
VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.
Electrophoresis 18:1243-1251(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY 2D-GEL.
[5]"Interaction of the hydrogenase accessory protein HypC with HycE, the large subunit of Escherichia coli hydrogenase 3 during enzyme maturation."
Drapal N., Boeck A.
Biochemistry 37:2941-2948(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X54543 Genomic DNA. Translation: CAA38414.1.
U29579 Genomic DNA. Translation: AAA69238.1.
U00096 Genomic DNA. Translation: AAC75770.1.
AP009048 Genomic DNA. Translation: BAE76805.1.
PIRS15199.
RefSeqNP_417208.1. NC_000913.3.
YP_490937.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2OT2NMR-A1-90[»]
ProteinModelPortalP0AAM3.
SMRP0AAM3. Positions 1-90.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-36430N.
IntActP0AAM3. 9 interactions.
MINTMINT-1223094.
STRING511145.b2728.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC75770; AAC75770; b2728.
BAE76805; BAE76805; BAE76805.
GeneID12932432.
947192.
KEGGecj:Y75_p2666.
eco:b2728.
PATRIC32120856. VBIEscCol129921_2820.

Organism-specific databases

EchoBASEEB0480.
EcoGeneEG10485. hypC.

Phylogenomic databases

eggNOGCOG0298.
HOGENOMHOG000278755.
KOK04653.
OMAQKMGADY.
OrthoDBEOG6GR3F3.
PhylomeDBP0AAM3.
ProtClustDBPRK10409.

Enzyme and pathway databases

BioCycEcoCyc:EG10485-MONOMER.
ECOL316407:JW2698-MONOMER.

Gene expression databases

GenevestigatorP0AAM3.

Family and domain databases

InterProIPR019812. Hydgase_assmbl_chp_CS.
IPR001109. Hydrogenase_HupF/HypC.
[Graphical view]
PfamPF01455. HupF_HypC. 1 hit.
[Graphical view]
PRINTSPR00445. HUPFHYPC.
TIGRFAMsTIGR00074. hypC_hupF. 1 hit.
PROSITEPS01097. HUPF_HYPC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP0AAM3.
PROP0AAM3.

Entry information

Entry nameHYPC_ECOLI
AccessionPrimary (citable) accession number: P0AAM3
Secondary accession number(s): P24191, Q2MAA1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene