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Protein

Protein NrfC

Gene

nrfC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi49Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi52Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi56Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi92Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi95Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi100Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi104Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi125Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi128Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi131Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi135Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi152Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi155Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi168Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi172Iron-sulfur 1 (4Fe-4S)By similarity1

GO - Molecular functioni

  • 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • nitrite reductase (cytochrome, ammonia-forming) activity Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:NRFC-MONOMER.
ECOL316407:JW4033-MONOMER.
MetaCyc:NRFC-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NrfC
Gene namesi
Name:nrfC
Synonyms:yjcJ
Ordered Locus Names:b4072, JW4033
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11946. nrfC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Tat-type signalPROSITE-ProRule annotationAdd BLAST27
ChainiPRO_000004227628 – 223Protein NrfCAdd BLAST196

Post-translational modificationi

Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Proteomic databases

PaxDbiP0AAK7.
PRIDEiP0AAK7.

Interactioni

Protein-protein interaction databases

BioGridi4263519. 7 interactors.
IntActiP0AAK7. 3 interactors.
STRINGi511145.b4072.

Structurei

3D structure databases

ProteinModelPortaliP0AAK7.
SMRiP0AAK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 654Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST29
Domaini83 – 1144Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST32
Domaini116 – 1454Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd BLAST30

Sequence similaritiesi

Contains 3 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4105D3S. Bacteria.
COG0437. LUCA.
HOGENOMiHOG000163388.
InParanoidiP0AAK7.
KOiK04014.
OMAiKRYAMVH.
PhylomeDBiP0AAK7.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR017567. Cyt_c_NO2Rdtase_NrfC.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF00037. Fer4. 1 hit.
PF13247. Fer4_11. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03149. cyt_nit_nrfC. 1 hit.
TIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 3 hits.
PS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AAK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWSRRQFLT GVGVLAAVSG TAGRVVAKTL NINGVRYGMV HDESLCIGCT
60 70 80 90 100
ACMDACREVN KVPEGVSRLT IIRSEPQGEF PDVKYRFFRK SCQHCDHAPC
110 120 130 140 150
VDVCPTGASF RDAASGIVDV NPDLCVGCQY CIAACPYRVR FIHPVTKTAD
160 170 180 190 200
KCDFCRKTNL QAGKLPACVE ACPTKALTFG NLDDPNSEIS QLLRQKPTYR
210 220
YKLALGTKPK LYRVPFKYGE VSQ
Length:223
Mass (Da):24,567
Last modified:October 11, 2005 - v1
Checksum:i676C3264D341FC8E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65 – 66GV → AS in AAC43166 (PubMed:8265357).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72298 Genomic DNA. Translation: CAA51043.1.
U00006 Genomic DNA. Translation: AAC43166.1.
U00096 Genomic DNA. Translation: AAC77042.1.
AP009048 Genomic DNA. Translation: BAE78074.1.
PIRiC57987.
RefSeqiNP_418496.1. NC_000913.3.
WP_000220281.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77042; AAC77042; b4072.
BAE78074; BAE78074; BAE78074.
GeneIDi948581.
KEGGiecj:JW4033.
eco:b4072.
PATRICi32123693. VBIEscCol129921_4195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72298 Genomic DNA. Translation: CAA51043.1.
U00006 Genomic DNA. Translation: AAC43166.1.
U00096 Genomic DNA. Translation: AAC77042.1.
AP009048 Genomic DNA. Translation: BAE78074.1.
PIRiC57987.
RefSeqiNP_418496.1. NC_000913.3.
WP_000220281.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAK7.
SMRiP0AAK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263519. 7 interactors.
IntActiP0AAK7. 3 interactors.
STRINGi511145.b4072.

Proteomic databases

PaxDbiP0AAK7.
PRIDEiP0AAK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77042; AAC77042; b4072.
BAE78074; BAE78074; BAE78074.
GeneIDi948581.
KEGGiecj:JW4033.
eco:b4072.
PATRICi32123693. VBIEscCol129921_4195.

Organism-specific databases

EchoBASEiEB1889.
EcoGeneiEG11946. nrfC.

Phylogenomic databases

eggNOGiENOG4105D3S. Bacteria.
COG0437. LUCA.
HOGENOMiHOG000163388.
InParanoidiP0AAK7.
KOiK04014.
OMAiKRYAMVH.
PhylomeDBiP0AAK7.

Enzyme and pathway databases

BioCyciEcoCyc:NRFC-MONOMER.
ECOL316407:JW4033-MONOMER.
MetaCyc:NRFC-MONOMER.

Miscellaneous databases

PROiP0AAK7.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR017567. Cyt_c_NO2Rdtase_NrfC.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF00037. Fer4. 1 hit.
PF13247. Fer4_11. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03149. cyt_nit_nrfC. 1 hit.
TIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 3 hits.
PS51318. TAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRFC_ECOLI
AccessioniPrimary (citable) accession number: P0AAK7
Secondary accession number(s): P32708, Q2M6N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.