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Protein

Protein NrfC

Gene

nrfC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi49Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi52Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi56Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi92Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi95Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi100Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi104Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi125Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi128Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi131Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi135Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi152Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi155Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi168Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi172Iron-sulfur 1 (4Fe-4S)By similarity1

GO - Molecular functioni

  • 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • nitrite reductase (cytochrome, ammonia-forming) activity Source: EcoCyc

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:NRFC-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NrfC
Gene namesi
Name:nrfC
Synonyms:yjcJ
Ordered Locus Names:b4072, JW4033
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11946 nrfC

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Tat-type signalPROSITE-ProRule annotationAdd BLAST27
ChainiPRO_000004227628 – 223Protein NrfCAdd BLAST196

Post-translational modificationi

Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Proteomic databases

PaxDbiP0AAK7
PRIDEiP0AAK7

Interactioni

Protein-protein interaction databases

BioGridi4263519, 39 interactors
IntActiP0AAK7, 3 interactors
STRINGi316385.ECDH10B_4263

Structurei

3D structure databases

ProteinModelPortaliP0AAK7
SMRiP0AAK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 654Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST29
Domaini83 – 1144Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST32
Domaini116 – 1454Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4105D3S Bacteria
COG0437 LUCA
HOGENOMiHOG000163388
InParanoidiP0AAK7
KOiK04014
OMAiCMHCENT
PhylomeDBiP0AAK7

Family and domain databases

InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR017567 Cyt_c_NO2Rdtase_NrfC
IPR006311 TAT_signal
IPR019546 TAT_signal_bac_arc
PfamiView protein in Pfam
PF00037 Fer4, 1 hit
PF13247 Fer4_11, 1 hit
TIGRFAMsiTIGR03149 cyt_nit_nrfC, 1 hit
TIGR01409 TAT_signal_seq, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 3 hits
PS51318 TAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AAK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWSRRQFLT GVGVLAAVSG TAGRVVAKTL NINGVRYGMV HDESLCIGCT
60 70 80 90 100
ACMDACREVN KVPEGVSRLT IIRSEPQGEF PDVKYRFFRK SCQHCDHAPC
110 120 130 140 150
VDVCPTGASF RDAASGIVDV NPDLCVGCQY CIAACPYRVR FIHPVTKTAD
160 170 180 190 200
KCDFCRKTNL QAGKLPACVE ACPTKALTFG NLDDPNSEIS QLLRQKPTYR
210 220
YKLALGTKPK LYRVPFKYGE VSQ
Length:223
Mass (Da):24,567
Last modified:October 11, 2005 - v1
Checksum:i676C3264D341FC8E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65 – 66GV → AS in AAC43166 (PubMed:8265357).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72298 Genomic DNA Translation: CAA51043.1
U00006 Genomic DNA Translation: AAC43166.1
U00096 Genomic DNA Translation: AAC77042.1
AP009048 Genomic DNA Translation: BAE78074.1
PIRiC57987
RefSeqiNP_418496.1, NC_000913.3
WP_000220281.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77042; AAC77042; b4072
BAE78074; BAE78074; BAE78074
GeneIDi948581
KEGGiecj:JW4033
eco:b4072
PATRICifig|1411691.4.peg.2632

Similar proteinsi

Entry informationi

Entry nameiNRFC_ECOLI
AccessioniPrimary (citable) accession number: P0AAK7
Secondary accession number(s): P32708, Q2M6N2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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