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Protein

Malonyl CoA-acyl carrier protein transacylase

Gene

fabD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei921
Active sitei2011

GO - Molecular functioni

  • [acyl-carrier-protein] S-malonyltransferase activity Source: EcoCyc

GO - Biological processi

  • fatty acid biosynthetic process Source: EcoCyc

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:MALONYL-COA-ACP-TRANSACYL-MONOMER
MetaCyc:MALONYL-COA-ACP-TRANSACYL-MONOMER
UniPathwayiUPA00094

Chemistry databases

SwissLipidsiSLP:000001778

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
Short name:
MCT
Gene namesi
Name:fabD
Synonyms:tfpA
Ordered Locus Names:b1092, JW1078
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11317 fabD

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00001942132 – 309Malonyl CoA-acyl carrier protein transacylaseAdd BLAST308

Proteomic databases

EPDiP0AAI9
PaxDbiP0AAI9
PRIDEiP0AAI9

2D gel databases

SWISS-2DPAGEiP0AAI9

Interactioni

Protein-protein interaction databases

BioGridi4263368375 interactors.
DIPiDIP-47923N
IntActiP0AAI9 4 interactors.
STRINGi316385.ECDH10B_1164

Structurei

Secondary structure

1309
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Turni16 – 19Combined sources4
Helixi20 – 25Combined sources6
Helixi28 – 40Combined sources13
Helixi44 – 50Combined sources7
Helixi53 – 56Combined sources4
Helixi59 – 79Combined sources21
Beta strandi86 – 91Combined sources6
Helixi93 – 101Combined sources9
Helixi107 – 124Combined sources18
Beta strandi129 – 137Combined sources9
Helixi140 – 150Combined sources11
Beta strandi156 – 163Combined sources8
Beta strandi166 – 172Combined sources7
Helixi173 – 185Combined sources13
Beta strandi189 – 193Combined sources5
Helixi203 – 205Combined sources3
Helixi206 – 217Combined sources12
Turni231 – 233Combined sources3
Helixi240 – 252Combined sources13
Helixi257 – 266Combined sources10
Beta strandi271 – 274Combined sources4
Beta strandi276 – 279Combined sources4
Helixi280 – 288Combined sources9
Beta strandi293 – 296Combined sources4
Helixi300 – 306Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MLAX-ray1.50A1-309[»]
2G1HX-ray1.86A2-309[»]
2G2OX-ray1.76A2-309[»]
2G2YX-ray2.26A2-309[»]
2G2ZX-ray2.80A2-309[»]
ProteinModelPortaliP0AAI9
SMRiP0AAI9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AAI9

Family & Domainsi

Sequence similaritiesi

Belongs to the FabD family.Curated

Phylogenomic databases

eggNOGiENOG4105CJF Bacteria
COG0331 LUCA
HOGENOMiHOG000036503
InParanoidiP0AAI9
KOiK00645
OMAiAANYNCP
PhylomeDBiP0AAI9

Family and domain databases

Gene3Di3.40.366.102 hits
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR024925 Malonyl_CoA-ACP_transAc
IPR004410 Malonyl_CoA-ACP_transAc_FabD
IPR016036 Malonyl_transacylase_ACP-bd
IPR020801 PKS_acyl_transferase
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PIRSFiPIRSF000446 Mct, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SUPFAMiSSF52151 SSF52151, 2 hits
SSF55048 SSF55048, 1 hit
TIGRFAMsiTIGR00128 fabD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AAI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQFAFVFPG QGSQTVGMLA DMAASYPIVE ETFAEASAAL GYDLWALTQQ
60 70 80 90 100
GPAEELNKTW QTQPALLTAS VALYRVWQQQ GGKAPAMMAG HSLGEYSALV
110 120 130 140 150
CAGVIDFADA VRLVEMRGKF MQEAVPEGTG AMAAIIGLDD ASIAKACEEA
160 170 180 190 200
AEGQVVSPVN FNSPGQVVIA GHKEAVERAG AACKAAGAKR ALPLPVSVPS
210 220 230 240 250
HCALMKPAAD KLAVELAKIT FNAPTVPVVN NVDVKCETNG DAIRDALVRQ
260 270 280 290 300
LYNPVQWTKS VEYMAAQGVE HLYEVGPGKV LTGLTKRIVD TLTASALNEP

SAMAAALEL
Length:309
Mass (Da):32,417
Last modified:January 23, 2007 - v2
Checksum:i3572E0681D14AB4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87040 Genomic DNA Translation: AAA23742.1
Z11565 Genomic DNA Translation: CAA77658.1
U00096 Genomic DNA Translation: AAC74176.1
AP009048 Genomic DNA Translation: BAA35900.1
M84991 Genomic DNA Translation: AAA23738.1
PIRiB41856
RefSeqiNP_415610.1, NC_000913.3
WP_000191372.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74176; AAC74176; b1092
BAA35900; BAA35900; BAA35900
GeneIDi945766
KEGGiecj:JW1078
eco:b1092
PATRICifig|1411691.4.peg.1176

Similar proteinsi

Entry informationi

Entry nameiFABD_ECOLI
AccessioniPrimary (citable) accession number: P0AAI9
Secondary accession number(s): P25715
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome