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Protein

Aliphatic sulfonates import ATP-binding protein SsuB

Gene

ssuB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system (Probable).2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 518ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:YCBE-MONOMER.
ECOL316407:JW0916-MONOMER.
MetaCyc:YCBE-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aliphatic sulfonates import ATP-binding protein SsuBUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:ssuBUniRule annotation
Synonyms:ycbE
Ordered Locus Names:b0933, JW0916
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12358. ssuB.

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Aliphatic sulfonates import ATP-binding protein SsuBPRO_0000092976Add
BLAST

Proteomic databases

PaxDbiP0AAI1.
PRIDEiP0AAI1.

Expressioni

Inductioni

Repressed by sulfate and cystine. Transcriptionally regulated by cbl.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (SsuB), two transmembrane proteins (SsuC) and a solute-binding protein (SsuA).UniRule annotation

Protein-protein interaction databases

BioGridi4261879. 12 interactions.
IntActiP0AAI1. 7 interactions.
STRINGi511145.b0933.

Structurei

3D structure databases

ProteinModelPortaliP0AAI1.
SMRiP0AAI1. Positions 14-243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 233222ABC transporterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2Y. Bacteria.
COG1116. LUCA.
InParanoidiP0AAI1.
KOiK15555.
OMAiTRIEMQS.
OrthoDBiEOG6T7N3V.
PhylomeDBiP0AAI1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR017875. SsuB.
[Graphical view]
PANTHERiPTHR24220:SF365. PTHR24220:SF365. 1 hit.
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51291. SSUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AAI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTARLNQGT PLLLNAVSKH YAENIVLNQL DLHIPAGQFV AVVGRSGGGK
60 70 80 90 100
STLLRLLAGL ETPTAGDVLA GTTPLAEIQE DTRMMFQDAR LLPWKSVIDN
110 120 130 140 150
VGLGLKGQWR DAARRALAAV GLENRAGEWP AALSGGQKQR VALARALIHR
160 170 180 190 200
PGLLLLDEPL GALDALTRLE MQDLIVSLWQ EHGFTVLLVT HDVSEAVAMA
210 220 230 240 250
DRVLLIEEGK IGLDLTVDIP RPRRLGSVRL AELEAEVLQR VMQRGESETR

LRKQG
Length:255
Mass (Da):27,738
Last modified:October 11, 2005 - v1
Checksum:i6FA276AD6E7FACE1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1655GALDA → RGAGR in M15273 (PubMed:3549459).Curated
Sequence conflicti232 – 2332EL → DV in M15273 (PubMed:3549459).Curated
Sequence conflicti236 – 2372EV → RS in M15273 (PubMed:3549459).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237695 Genomic DNA. Translation: CAB40393.1.
U00096 Genomic DNA. Translation: AAC74019.1.
AP009048 Genomic DNA. Translation: BAA35685.1.
M15273 Genomic DNA. No translation available.
PIRiD64833.
RefSeqiNP_415453.1. NC_000913.3.
WP_001090506.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74019; AAC74019; b0933.
BAA35685; BAA35685; BAA35685.
GeneIDi947220.
KEGGiecj:JW0916.
eco:b0933.
PATRICi32117085. VBIEscCol129921_0967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237695 Genomic DNA. Translation: CAB40393.1.
U00096 Genomic DNA. Translation: AAC74019.1.
AP009048 Genomic DNA. Translation: BAA35685.1.
M15273 Genomic DNA. No translation available.
PIRiD64833.
RefSeqiNP_415453.1. NC_000913.3.
WP_001090506.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAI1.
SMRiP0AAI1. Positions 14-243.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261879. 12 interactions.
IntActiP0AAI1. 7 interactions.
STRINGi511145.b0933.

Proteomic databases

PaxDbiP0AAI1.
PRIDEiP0AAI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74019; AAC74019; b0933.
BAA35685; BAA35685; BAA35685.
GeneIDi947220.
KEGGiecj:JW0916.
eco:b0933.
PATRICi32117085. VBIEscCol129921_0967.

Organism-specific databases

EchoBASEiEB2261.
EcoGeneiEG12358. ssuB.

Phylogenomic databases

eggNOGiENOG4105E2Y. Bacteria.
COG1116. LUCA.
InParanoidiP0AAI1.
KOiK15555.
OMAiTRIEMQS.
OrthoDBiEOG6T7N3V.
PhylomeDBiP0AAI1.

Enzyme and pathway databases

BioCyciEcoCyc:YCBE-MONOMER.
ECOL316407:JW0916-MONOMER.
MetaCyc:YCBE-MONOMER.

Miscellaneous databases

PROiP0AAI1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR017875. SsuB.
[Graphical view]
PANTHERiPTHR24220:SF365. PTHR24220:SF365. 1 hit.
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51291. SSUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Escherichia coli ssuEADCB gene cluster is required for the utilization of sulfur from aliphatic sulfonates and is regulated by the transcriptional activator Cbl."
    Van der Ploeg J.R., Iwanicka-Nowicka R., Bykowski T., Hryniewicz M.M., Leisinger T.
    J. Biol. Chem. 274:29358-29365(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN ALIPHATIC SULFONATES TRANSPORT, INDUCTION.
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "The nucleotide sequence of the pepN gene and its over-expression in Escherichia coli."
    McCaman M.T., Gabe J.D.
    Gene 48:145-153(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 161-255.
    Strain: K12.
  6. "Intrinsic and extrinsic approaches for detecting genes in a bacterial genome."
    Borodovsky M., Rudd K.E., Koonin E.V.
    Nucleic Acids Res. 22:4756-4767(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "Deletion analysis of the Escherichia coli taurine and alkanesulfonate transport systems."
    Eichhorn E., van der Ploeg J.R., Leisinger T.
    J. Bacteriol. 182:2687-2695(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ALIPHATIC SULFONATES TRANSPORT.
    Strain: K12.
  8. "Sulfonate-sulfur metabolism and its regulation in Escherichia coli."
    van der Ploeg J.R., Eichhorn E., Leisinger T.
    Arch. Microbiol. 176:1-8(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiSSUB_ECOLI
AccessioniPrimary (citable) accession number: P0AAI1
Secondary accession number(s): P38053, P75850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: January 20, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.