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Protein

Aliphatic sulfonates import ATP-binding protein SsuB

Gene

ssuB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system (Probable).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 51ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:YCBE-MONOMER.
MetaCyc:YCBE-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aliphatic sulfonates import ATP-binding protein SsuBUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:ssuBUniRule annotation
Synonyms:ycbE
Ordered Locus Names:b0933, JW0916
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12358. ssuB.

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000929761 – 255Aliphatic sulfonates import ATP-binding protein SsuBAdd BLAST255

Proteomic databases

PaxDbiP0AAI1.
PRIDEiP0AAI1.

Expressioni

Inductioni

Repressed by sulfate and cystine. Transcriptionally regulated by cbl.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (SsuB), two transmembrane proteins (SsuC) and a solute-binding protein (SsuA).UniRule annotation

Protein-protein interaction databases

BioGridi4261879. 12 interactors.
IntActiP0AAI1. 7 interactors.
STRINGi316385.ECDH10B_1003.

Structurei

3D structure databases

ProteinModelPortaliP0AAI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 233ABC transporterUniRule annotationAdd BLAST222

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family. [View classification]UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2Y. Bacteria.
COG1116. LUCA.
InParanoidiP0AAI1.
KOiK15555.
PhylomeDBiP0AAI1.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR017875. SsuB.
PANTHERiPTHR42788:SF7. PTHR42788:SF7. 1 hit.
PfamiView protein in Pfam
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51291. SSUB. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AAI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTARLNQGT PLLLNAVSKH YAENIVLNQL DLHIPAGQFV AVVGRSGGGK
60 70 80 90 100
STLLRLLAGL ETPTAGDVLA GTTPLAEIQE DTRMMFQDAR LLPWKSVIDN
110 120 130 140 150
VGLGLKGQWR DAARRALAAV GLENRAGEWP AALSGGQKQR VALARALIHR
160 170 180 190 200
PGLLLLDEPL GALDALTRLE MQDLIVSLWQ EHGFTVLLVT HDVSEAVAMA
210 220 230 240 250
DRVLLIEEGK IGLDLTVDIP RPRRLGSVRL AELEAEVLQR VMQRGESETR

LRKQG
Length:255
Mass (Da):27,738
Last modified:October 11, 2005 - v1
Checksum:i6FA276AD6E7FACE1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161 – 165GALDA → RGAGR in M15273 (PubMed:3549459).Curated5
Sequence conflicti232 – 233EL → DV in M15273 (PubMed:3549459).Curated2
Sequence conflicti236 – 237EV → RS in M15273 (PubMed:3549459).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237695 Genomic DNA. Translation: CAB40393.1.
U00096 Genomic DNA. Translation: AAC74019.1.
AP009048 Genomic DNA. Translation: BAA35685.1.
M15273 Genomic DNA. No translation available.
PIRiD64833.
RefSeqiNP_415453.1. NC_000913.3.
WP_001090506.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74019; AAC74019; b0933.
BAA35685; BAA35685; BAA35685.
GeneIDi947220.
KEGGiecj:JW0916.
eco:b0933.
PATRICifig|1411691.4.peg.1341.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSSUB_ECOLI
AccessioniPrimary (citable) accession number: P0AAI1
Secondary accession number(s): P38053, P75850
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 5, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families