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Protein

Peptide transport system ATP-binding protein SapF

Gene

sapF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi47 – 548ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:SAPF-MONOMER.
ECOL316407:JW1283-MONOMER.

Protein family/group databases

TCDBi3.A.1.5.42. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide transport system ATP-binding protein SapF
Gene namesi
Name:sapF
Ordered Locus Names:b1290, JW1283
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12305. sapF.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Peptide transport system ATP-binding protein SapFPRO_0000092968Add
BLAST

Proteomic databases

PaxDbiP0AAH8.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ybiTP0A9U32EBI-558765,EBI-558999

Protein-protein interaction databases

BioGridi4263241. 403 interactions.
DIPiDIP-35903N.
IntActiP0AAH8. 10 interactions.
STRINGi511145.b1290.

Structurei

3D structure databases

ProteinModelPortaliP0AAH8.
SMRiP0AAH8. Positions 25-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 251246ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108JQ2. Bacteria.
COG4167. LUCA.
InParanoidiP0AAH8.
KOiK19230.
OMAiQIRMIFQ.
OrthoDBiEOG6T7N3V.
PhylomeDBiP0AAH8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AAH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIETLLEVRN LSKTFRYRTG WFRRQTVEAV KPLSFTLREG QTLAIIGENG
60 70 80 90 100
SGKSTLAKML AGMIEPTSGE LLIDDHPLHF GDYSFRSQRI RMIFQDPSTS
110 120 130 140 150
LNPRQRISQI LDFPLRLNTD LEPEQRRKQI IETMRMVGLL PDHVSYYPHM
160 170 180 190 200
LAPGQKQRLG LARALILRPK VIIADEALAS LDMSMRSQLI NLMLELQEKQ
210 220 230 240 250
GISYIYVTQH IGMMKHISDQ VLVMHQGEVV ERGSTADVLA SPLHELTKRL
260
IAGHFGEALT ADAWRKDR
Length:268
Mass (Da):30,571
Last modified:October 11, 2005 - v1
Checksum:iF3B98BC9DC6DCBFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08190 Unassigned DNA. Translation: AAA17671.1.
X97282 Genomic DNA. Translation: CAA65941.1.
U00096 Genomic DNA. Translation: AAC74372.1.
AP009048 Genomic DNA. Translation: BAA14843.1.
PIRiE64877.
RefSeqiNP_415806.1. NC_000913.3.
WP_000573407.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74372; AAC74372; b1290.
BAA14843; BAA14843; BAA14843.
GeneIDi945335.
KEGGiecj:JW1283.
eco:b1290.
PATRICi32117850. VBIEscCol129921_1345.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08190 Unassigned DNA. Translation: AAA17671.1.
X97282 Genomic DNA. Translation: CAA65941.1.
U00096 Genomic DNA. Translation: AAC74372.1.
AP009048 Genomic DNA. Translation: BAA14843.1.
PIRiE64877.
RefSeqiNP_415806.1. NC_000913.3.
WP_000573407.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAH8.
SMRiP0AAH8. Positions 25-256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263241. 403 interactions.
DIPiDIP-35903N.
IntActiP0AAH8. 10 interactions.
STRINGi511145.b1290.

Protein family/group databases

TCDBi3.A.1.5.42. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0AAH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74372; AAC74372; b1290.
BAA14843; BAA14843; BAA14843.
GeneIDi945335.
KEGGiecj:JW1283.
eco:b1290.
PATRICi32117850. VBIEscCol129921_1345.

Organism-specific databases

EchoBASEiEB2211.
EcoGeneiEG12305. sapF.

Phylogenomic databases

eggNOGiENOG4108JQ2. Bacteria.
COG4167. LUCA.
InParanoidiP0AAH8.
KOiK19230.
OMAiQIRMIFQ.
OrthoDBiEOG6T7N3V.
PhylomeDBiP0AAH8.

Enzyme and pathway databases

BioCyciEcoCyc:SAPF-MONOMER.
ECOL316407:JW1283-MONOMER.

Miscellaneous databases

PROiP0AAH8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Bergler H., Ebeling A., Fuchsbichler S., Hogenauer G., Turnowsky F.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Epstein W., Noelker E., Stumpe S., Tewes R., Schmid R., Bakker E.P.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiSAPF_ECOLI
AccessioniPrimary (citable) accession number: P0AAH8
Secondary accession number(s): P36637
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: January 20, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.