Reviewed,
UniProtKB/Swiss-Prot P0AAG6 (MDLB_ECOL6)
Last modified
November 3, 2009.
Version 35.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Multidrug resistance-like ATP-binding protein mdlB EC=3.6.3.44 | ||||
| Gene names |
| ||||
| Organism | Escherichia coli O6 [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 217992 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 593 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out). |
| Subcellular location | Cell inner membrane; Multi-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family. [View classification] Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transport |
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Domain | Transmembrane |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | transport Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW xenobiotic-transporting ATPase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 593 | 593 | Multidrug resistance-like ATP-binding protein mdlB | PRO_0000092498 | |||||
Regions | |||||||||
| Topological domain | 1 – 25 | 25 | Cytoplasmic Potential | ||||||
| Transmembrane | 26 – 46 | 21 | Potential | ||||||
| Topological domain | 47 – 62 | 16 | Periplasmic Potential | ||||||
| Transmembrane | 63 – 83 | 21 | Potential | ||||||
| Topological domain | 84 – 140 | 57 | Cytoplasmic Potential | ||||||
| Transmembrane | 141 – 161 | 21 | Potential | ||||||
| Topological domain | 162 – 164 | 3 | Periplasmic Potential | ||||||
| Transmembrane | 165 – 185 | 21 | Potential | ||||||
| Topological domain | 186 – 254 | 69 | Cytoplasmic Potential | ||||||
| Transmembrane | 255 – 275 | 21 | Potential | ||||||
| Topological domain | 276 – 278 | 3 | Periplasmic Potential | ||||||
| Transmembrane | 279 – 299 | 21 | Potential | ||||||
| Topological domain | 300 – 593 | 294 | Cytoplasmic Potential | ||||||
| Domain | 25 – 310 | 286 | ABC transmembrane type-1 | ||||||
| Domain | 341 – 574 | 234 | ABC transporter | ||||||
| Nucleotide binding | 374 – 381 | 8 | ATP Potential | ||||||
Sequences
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References
| [1] | "Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli." Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R. Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed: 12471157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O6:H1 / CFT073 / ATCC 700928 / UPEC. |
Cross-references
Sequence databases | |
|---|---|
| AE014075 Genomic DNA. Translation: AAN79044.1. Different initiation. | |
| RefSeq | NP_752500.2. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1MT0 based on UniProtKB P08716. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1040474. |
| GenomeReviews | Gene locus c0566 in contig AE014075_GR. |
| KEGG | ecc:c0566. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P0AAG6. |
| OMA | VHEESGP. |
Enzyme and pathway databases | |
| BRENDA | 3.6.3.44. 292881. |
Family and domain databases | |
| InterPro | IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view] |
| Pfam | PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view] |
| ProDom | PD000006. ABC_transporter. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00382. AAA. 1 hit. [Graphical view] |
| PROSITE | PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MDLB_ECOL6 | ||||||||
| Accession | Primary (citable) accession number: P0AAG6 Secondary accession number(s): P30751, P75706, P77117 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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