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Protein

Multidrug resistance-like ATP-binding protein MdlB

Gene

mdlB

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi374 – 381ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-like ATP-binding protein MdlB (EC:3.6.3.44)
Gene namesi
Name:mdlB
Ordered Locus Names:c0566
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001410 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini47 – 62PeriplasmicSequence analysisAdd BLAST16
Transmembranei63 – 83HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini84 – 140CytoplasmicSequence analysisAdd BLAST57
Transmembranei141 – 161HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini162 – 164PeriplasmicSequence analysis3
Transmembranei165 – 185HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini186 – 254CytoplasmicSequence analysisAdd BLAST69
Transmembranei255 – 275HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini276 – 278PeriplasmicSequence analysis3
Transmembranei279 – 299HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini300 – 593CytoplasmicSequence analysisAdd BLAST294

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000924981 – 593Multidrug resistance-like ATP-binding protein MdlBAdd BLAST593

Interactioni

Protein-protein interaction databases

STRINGi199310.c0566.

Structurei

3D structure databases

ProteinModelPortaliP0AAG6.
SMRiP0AAG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 310ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST286
Domaini341 – 574ABC transporterPROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK18890.
OMAiVFITQRL.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AAG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSFSQLWPT LKRLLAYGSP WRKPLGIAVL MMWVAAAAEV SGPLLISYFI
60 70 80 90 100
DNMVAKNNLP LKVVAGLAAA YVGLQLFAAG LHYAQSLLFN RAAVGVVQQL
110 120 130 140 150
RTDVMDAALR QPLSEFDTQP VGQVISRVTN DTEVIRDLYV TVVATVLRSA
160 170 180 190 200
ALVGAMLVAM FSLDWRMALV AIMIFPVVLV VMVIYQRYST PIVRRVRAYL
210 220 230 240 250
ADINDGFNEI INGMSVIQQF RQQARFGERM GEASRSHYMA RMQTLRLDGF
260 270 280 290 300
LLRPLLSLFS SLILCGLLML FGFSASGTIE VGVLYAFISY LGRLNEPLIE
310 320 330 340 350
LTTQQAMLQQ AVVAGERVFE LMDGPRQQYG NDDRPLQSGT IEVDNVSFAY
360 370 380 390 400
RDDNLVLKNI NLSVPSRNFV ALVGHTGSGK STLASLLMGY YPLTEGEIRL
410 420 430 440 450
DGRPLSSLSH SALRQGVAMV QQDPVVLADT FLANVTLGRD ISEERVWQAL
460 470 480 490 500
ETVQLAELAR SMSDGIYTPL GEQGNNLSVG QKQLLALARV LVETPQILIL
510 520 530 540 550
DEATASIDSG TEQAIQHALA AVREHTTLVV IAHRLSTIVD ADTILVLHRG
560 570 580 590
QAVEQGTHQQ LLAAQGRYWQ MYQLQLAGEE LAASVREEES LSA
Length:593
Mass (Da):65,222
Last modified:October 11, 2005 - v1
Checksum:iCF1EE70009EB05D8
GO

Sequence cautioni

The sequence AAN79044 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN79044.1. Different initiation.
RefSeqiWP_001256201.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN79044; AAN79044; c0566.
KEGGiecc:c0566.

Similar proteinsi

Entry informationi

Entry nameiMDLB_ECOL6
AccessioniPrimary (citable) accession number: P0AAG6
Secondary accession number(s): P30751, P75706, P77117
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 7, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families