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Protein

Glutamate/aspartate import ATP-binding protein GltL

Gene

gltL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for energy coupling to the transport system.1 Publication

Catalytic activityi

ATP + H2O + polar amino acid(Out) = ADP + phosphate + polar amino acid(In).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 41ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:GLTL-MONOMER.
ECOL316407:JW0647-MONOMER.
MetaCyc:GLTL-MONOMER.

Protein family/group databases

TCDBi3.A.1.3.4. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate/aspartate import ATP-binding protein GltLCurated (EC:3.6.3.211 Publication)
Gene namesi
Name:gltL
Ordered Locus Names:b0652, JW0647
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12663. gltL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000923351 – 241Glutamate/aspartate import ATP-binding protein GltLAdd BLAST241

Proteomic databases

PaxDbiP0AAG3.
PRIDEiP0AAG3.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (GltL), two transmembrane proteins (GltJ and GltK) and a solute-binding protein (GltI).1 Publication

Protein-protein interaction databases

BioGridi4259911. 8 interactors.
DIPiDIP-48246N.
IntActiP0AAG3. 6 interactors.
MINTiMINT-1307893.
STRINGi511145.b0652.

Structurei

3D structure databases

ProteinModelPortaliP0AAG3.
SMRiP0AAG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 236ABC transporterPROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CDA. Bacteria.
COG1126. LUCA.
InParanoidiP0AAG3.
KOiK10004.
OMAiVTIARTM.
PhylomeDBiP0AAG3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR030679. ABC_ATPase_HisP-typ.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030206. GltL/AatP.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24220:SF317. PTHR24220:SF317. 1 hit.
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF039085. ABC_ATPase_HisP. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AAG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITLKNVSKW YGHFQVLTDC STEVKKGEVV VVCGPSGSGK STLIKTVNGL
60 70 80 90 100
EPVQQGEITV DGIVVNDKKT DLAKLRSRVG MVFQHFELFP HLSIIENLTL
110 120 130 140 150
AQVKVLKRDK APAREKALKL LERVGLSAHA NKFPAQLSGG QQQRVAIARA
160 170 180 190 200
LCMDPIAMLF DEPTSALDPE MINEVLDVMV ELANEGMTMM VVTHEMGFAR
210 220 230 240
KVANRVIFMD EGKIVEDSPK DAFFDDPKSD RAKDFLAKIL H
Length:241
Mass (Da):26,661
Last modified:October 11, 2005 - v1
Checksum:i7643584D63FC424D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10981 Genomic DNA. Translation: AAA60982.1.
U82598 Genomic DNA. Translation: AAB40853.1.
U00096 Genomic DNA. Translation: AAC73753.1.
AP009048 Genomic DNA. Translation: BAA35304.1.
PIRiB64800.
RefSeqiNP_415185.1. NC_000913.3.
WP_000631384.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73753; AAC73753; b0652.
BAA35304; BAA35304; BAA35304.
GeneIDi945254.
KEGGiecj:JW0647.
eco:b0652.
PATRICi32116487. VBIEscCol129921_0683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10981 Genomic DNA. Translation: AAA60982.1.
U82598 Genomic DNA. Translation: AAB40853.1.
U00096 Genomic DNA. Translation: AAC73753.1.
AP009048 Genomic DNA. Translation: BAA35304.1.
PIRiB64800.
RefSeqiNP_415185.1. NC_000913.3.
WP_000631384.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAG3.
SMRiP0AAG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259911. 8 interactors.
DIPiDIP-48246N.
IntActiP0AAG3. 6 interactors.
MINTiMINT-1307893.
STRINGi511145.b0652.

Protein family/group databases

TCDBi3.A.1.3.4. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0AAG3.
PRIDEiP0AAG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73753; AAC73753; b0652.
BAA35304; BAA35304; BAA35304.
GeneIDi945254.
KEGGiecj:JW0647.
eco:b0652.
PATRICi32116487. VBIEscCol129921_0683.

Organism-specific databases

EchoBASEiEB2529.
EcoGeneiEG12663. gltL.

Phylogenomic databases

eggNOGiENOG4105CDA. Bacteria.
COG1126. LUCA.
InParanoidiP0AAG3.
KOiK10004.
OMAiVTIARTM.
PhylomeDBiP0AAG3.

Enzyme and pathway databases

BioCyciEcoCyc:GLTL-MONOMER.
ECOL316407:JW0647-MONOMER.
MetaCyc:GLTL-MONOMER.

Miscellaneous databases

PROiP0AAG3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR030679. ABC_ATPase_HisP-typ.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030206. GltL/AatP.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24220:SF317. PTHR24220:SF317. 1 hit.
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF039085. ABC_ATPase_HisP. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLTL_ECOLI
AccessioniPrimary (citable) accession number: P0AAG3
Secondary accession number(s): P41076
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.