P0AAF6 (ARTP_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine transport ATP-binding protein ArtP
EC=3.6.3.-

Gene names

Name:	artP
Ordered Locus Names:	b0864, JW0848

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for energy coupling to the transport system. Ref.5
Subunit structure	The complex is composed of two ATP-binding proteins (ArtP), two transmembrane proteins (ArtM and ArtQ) and two solute-binding proteins (ArtJ and ArtI) Probable. Ref.5
Subcellular location	Cell inner membrane; Peripheral membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Amino-acid transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	amino acid transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Arginine transport ATP-binding protein ArtP		PRO_0000091939
Regions
	Domain	3 – 241	239	ABC transporter
	Nucleotide binding	35 – 42	8	ATP Potential
Experimental info
	Sequence conflict	94 – 95	2	WP → CA in CAA60101. Ref.1
	Sequence conflict	121	1	R → S in CAA60101. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P0AAF6 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: D5B50062E523413A	FASTA	242	27,022
	10 20 30 40 50 60 MSIQLNGINC FYGAHQALFD ITLDCPQGET LVLLGPSGAG KSSLLRVLNL LEMPRSGTLN 70 80 90 100 110 120 IAGNHFDFTK TPSDKAIRDL RRNVGMVFQQ YNLWPHLTVQ QNLIEAPCRV LGLSKDQALA 130 140 150 160 170 180 RAEKLLERLR LKPYSDRYPL HLSGGQQQRV AIARALMMEP QVLLFDEPTA ALDPEITAQI 190 200 210 220 230 240 VSIIRELAET NITQVIVTHE VEVARKTASR VVYMENGHIV EQGDASCFTE PQTEAFKNYL SH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Physical map location of the new artPIQMJ genes of Escherichia coli, encoding a periplasmic arginine transport system." Wissenbach U., Unden G. J. Bacteriol. 175:3687-3688(1993) [PubMed: 8501075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / AN387.
[2]	"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T. DNA Res. 3:137-155(1996) [PubMed: 8905232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"A third periplasmic transport system for L-arginine in Escherichia coli: molecular characterization of the artPIQMJ genes, arginine binding and transport." Wissenbach U., Six S., Bongaerts J., Ternes D., Steinwachs S., Unden G. Mol. Microbiol. 17:675-686(1995) [PubMed: 8801422] [Abstract] Cited for: FUNCTION, SUBUNIT.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X86160 Genomic DNA. Translation: CAA60101.1. U00096 Genomic DNA. Translation: AAC73951.1. AP009048 Genomic DNA. Translation: BAA35578.1.
PIR	H64824.
RefSeq	NP_415385.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P0AAF6.
SMR	P0AAF6. Positions 1-241.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-47917N.
IntAct	P0AAF6. 6 interactions.
MINT	MINT-1236053.
Protein family/group databases
TCDB	3.A.1.3.3. ATP-binding cassette (ABC) superfamily.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000000603; EBESCP00000000603; EBESCG00000000504. EBESCT00000014538; EBESCP00000013829; EBESCG00000013599.
GeneID	945489.
GenomeReviews	Gene locus JW0848 in contig AP009048_GR. Gene locus b0864 in contig U00096_GR.
KEGG	ecj:JW0848. eco:b0864.
PATRIC	32116935. VBIEscCol129921_0893.
Organism-specific databases
EchoBASE	EB1581.
EcoGene	EG11624. artP.
Phylogenomic databases
eggNOG	COG4161.
GeneTree	EBGT00050000008233.
HOGENOM	HBG758042.
OMA	IAGNQFD.
PhylomeDB	P0AAF6.
ProtClustDB	PRK11124.
Enzyme and pathway databases
BioCyc	EcoCyc:ARTP-MONOMER.
Gene expression databases
Genevestigator	P0AAF6.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K10000.
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARTP_ECOLI

Accession

Primary (citable) accession number: P0AAF6
Secondary accession number(s): P30858, P77355

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program